Top

Published in:

Open Access 01-01-2017 | Correspondence

Tau neuropathology correlates with FDG-PET, but not AV-1451-PET, in progressive supranuclear palsy

Authors: Ruben Smith, Michael Schöll, Michael Honer, Christer F. Nilsson, Elisabet Englund, Oskar Hansson

Published in: Acta Neuropathologica | Issue 1/2017

Excerpt

Radiotracers for tau have recently become available for positron emission tomography (PET) studies in neurodegenerative disorders. The currently most utilized tracer ¹⁸F-AV-1451 binds to paired helical filaments containing both 3R and 4R tau in Alzheimer’s disease (AD) in vitro [3, 4, 6]. Furthermore, ¹⁸F-AV-1451 can quantify AD-like tau pathology in MAPT R406W mutation carriers in vivo [7]. In corticobasal degeneration, there is a clear binding to 4R tau pathology, but SUVRs are generally lower than in AD [2, 5]. …

Available only for authorised users

Hansen AK, Knudsen K, Lillethorup TP et al (2016) In vivo imaging of neuromelanin in Parkinson’s disease using 18F-AV-1451 PET. Brain. doi:10.1093/brain/aww098

Josephs KA, Whitwell JL, Tacik P et al (2016) [18F]AV-1451 tau-PET uptake does correlate with quantitatively measured 4R-tau burden in autopsy-confirmed corticobasal degeneration. Acta Neuropathol 132:931–933. doi:10.1007/s00401-016-1618-1 CrossRefPubMed

Lowe VJ, Curran G, Fang P et al (2016) An autoradiographic evaluation of AV-1451 Tau PET in dementia. Acta Neuropathol Commun 4:58. doi:10.1186/s40478-016-0315-6 CrossRefPubMedPubMedCentral

Marquie M, Normandin MD, Vanderburg CR et al (2015) Validating novel tau positron emission tomography tracer [F-18]-AV-1451 (T807) on postmortem brain tissue. Ann Neurol 78:787–800. doi:10.1002/ana.24517 CrossRefPubMedPubMedCentral

McMillan CT, Irwin DJ, Nasrallah I et al (2016) Multimodal evaluation demonstrates in vivo 18F-AV-1451 uptake in autopsy-confirmed corticobasal degeneration. Acta Neuropathol 132:935–937. doi:10.1007/s00401-016-1640-3 CrossRefPubMed

Sander K, Lashley T, Gami P et al (2016) Characterization of tau positron emission tomography tracer [F]AV-1451 binding to postmortem tissue in Alzheimer’s disease, primary tauopathies, and other dementias. Alzheimers Dement. doi:10.1016/j.jalz.2016.01.003

Smith R, Puschmann A, Scholl M et al (2016) 18F-AV-1451 tau PET imaging correlates strongly with tau neuropathology in MAPT mutation carriers. Brain 139:2372–2379. doi:10.1093/brain/aww163 CrossRefPubMedPubMedCentral

Smith R, Schain M, Nilsson C et al (2016) Increased basal ganglia binding of 18 F-AV-1451 in patients with progressive supranuclear palsy. Mov Disord. doi:10.1002/mds.26813

Title: Tau neuropathology correlates with FDG-PET, but not AV-1451-PET, in progressive supranuclear palsy
Authors: Ruben Smith
Michael Schöll
Michael Honer
Christer F. Nilsson
Elisabet Englund
Oskar Hansson
Publication date: 01-01-2017
Publisher: Springer Berlin Heidelberg
Published in: Acta Neuropathologica / Issue 1/2017
Print ISSN: 0001-6322
Electronic ISSN: 1432-0533
DOI: https://doi.org/10.1007/s00401-016-1650-1

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Tau neuropathology correlates with FDG-PET, but not AV-1451-PET, in progressive supranuclear palsy

Excerpt

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Excerpt

Please log in to get access to this content

Other articles of this Issue 1/2017

Mir-223 regulates the number and function of myeloid-derived suppressor cells in multiple sclerosis and experimental autoimmune encephalomyelitis

Peripheral VH4+ plasmablasts demonstrate autoreactive B cell expansion toward brain antigens in early multiple sclerosis patients

Slow expansion of multiple sclerosis iron rim lesions: pathology and 7 T magnetic resonance imaging

eEF2K inhibition blocks Aβ42 neurotoxicity by promoting an NRF2 antioxidant response

The current consensus on the clinical management of intracranial ependymoma and its distinct molecular variants

Deep sequencing reveals persistence of cell-associated mumps vaccine virus in chronic encephalitis