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Published in: Acta Neuropathologica 4/2016

01-10-2016 | Original Paper

Prognostic impact of the 2016 WHO classification of diffuse gliomas in the French POLA cohort

Authors: Emeline Tabouret, Anh Tuan Nguyen, Caroline Dehais, Catherine Carpentier, François Ducray, Ahmed Idbaih, Karima Mokhtari, Anne Jouvet, Emmanuelle Uro-Coste, Carole Colin, Olivier Chinot, Hugues Loiseau, Elisabeth Moyal, Claude-Alain Maurage, Marc Polivka, Emmanuèle Lechapt-Zalcman, Christine Desenclos, David Meyronet, Jean-Yves Delattre, Dominique Figarella-Branger, For POLA Network

Published in: Acta Neuropathologica | Issue 4/2016

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Abstract

The new WHO classification of diffuse gliomas has been refined and now includes the 1p/19q codeletion, IDH1/2 mutation, and histone H3-K27M mutation. Our objective was to assess the prognostic value of the updated 2016 WHO classification in the French POLA cohort. All cases of high-grade oligodendroglial tumors sent for central pathological review and included into the French nationwide POLA cohort were reclassified according to the updated 4th WHO classification. In total, 1041 patients were included, with a median age at diagnosis of 50.4 years (range 17.1–84.4). Based on the new histomolecular classification, diagnoses included anaplastic oligodendroglioma IDH mutant and 1p/19q-codeleted (32.5 %), anaplastic astrocytoma IDH mutant (IDH mut) (11.0 %), anaplastic astrocytoma IDH wild type (IDH wt) (5.3 %), glioblastoma IDH mut (17.1 %), and glioblastoma IDH wt (33.2 %). Ten patients presented with a diffuse midline tumor, H3 K27M mutant. The new WHO classification was prognostic for progression-free survival (PFS) and overall survival (OS) (p < 0.001). We did not find prognosis differences between grades III and IV for IDH mut 1p/19q intact and IDH wt gliomas in univariate and multivariate analyses. Among anaplastic astrocytoma IDH wt, cases with chromosome arm 7p gain and 10q loss (55 %) had shorter PFS than the others (p = 0.027). In conclusion, the new WHO histomolecular classification of diffuse gliomas presented with high prognostic value. Grading was not discriminant between grade III and IV high-grade gliomas.
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Metadata
Title
Prognostic impact of the 2016 WHO classification of diffuse gliomas in the French POLA cohort
Authors
Emeline Tabouret
Anh Tuan Nguyen
Caroline Dehais
Catherine Carpentier
François Ducray
Ahmed Idbaih
Karima Mokhtari
Anne Jouvet
Emmanuelle Uro-Coste
Carole Colin
Olivier Chinot
Hugues Loiseau
Elisabeth Moyal
Claude-Alain Maurage
Marc Polivka
Emmanuèle Lechapt-Zalcman
Christine Desenclos
David Meyronet
Jean-Yves Delattre
Dominique Figarella-Branger
For POLA Network
Publication date
01-10-2016
Publisher
Springer Berlin Heidelberg
Published in
Acta Neuropathologica / Issue 4/2016
Print ISSN: 0001-6322
Electronic ISSN: 1432-0533
DOI
https://doi.org/10.1007/s00401-016-1611-8

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