Confirmation of R132H mutation of isocitrate dehydrogenase 1 as an independent prognostic factor in anaplastic astrocytoma

Excerpt

Identification of mutations affecting codon 132 of the enzyme cytosolic isocitrate dehydrogenase 1 (IDH1) in astrocytomas, oligodendrogliomas and secondary glioblastomas has influenced current concepts of diffuse gliomas. A recent study published in this journal demonstrated that in anaplastic astrocytomas and glioblastomas IDH1 mutation status better reflected patient prognosis than histological diagnosis according to the current WHO classification system [3]. Even more intriguingly, patients with IDH1 wild type anaplastic astrocytomas demonstrated not only shorter overall survival (OS) when compared to IDH1 mutant anaplastic astrocytoma patients, but even survived shorter than patients with IDH1 mutant glioblastoma. Results were based on data from the NOA-04 trial [7] and the German Glioma Network [6]. …