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Acta Neuropathologica
Published in: Acta Neuropathologica 5/2009

01-05-2009 | Review

Angiogenesis after cerebral ischemia

Authors: Heike Beck, Karl H. Plate

Published in: Acta Neuropathologica | Issue 5/2009

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Abstract

Though the vascular system of the adult brain is extremely stable under normal baseline conditions, endothelial cells start to proliferate in response to brain ischemia. The induction of angiogenesis, primarily in the ischemic boundary zone, enhances oxygen and nutrient supply to the affected tissue. Additionally, the generation of new blood vessels facilitates highly coupled neurorestorative processes including neurogenesis and synaptogenesis which in turn lead to improved functional recovery. To take advantage of angiogenesis as a therapeutic concept for stroke treatment, the knowledge of the precise molecular mechanisms is mandatory. Especially, since a couple of growth factors involved in post-ischemic angiogenesis may have detrimental adverse effects in the brain by increasing vascular permeability. This article summarizes the knowledge of molecular mechanisms of angiogenesis following cerebral ischemia. Finally, experimental pharmacological and cellular approaches to stimulate and enhance post-ischemic angiogenesis are discussed.
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Metadata
Title
Angiogenesis after cerebral ischemia
Authors
Heike Beck
Karl H. Plate
Publication date
01-05-2009
Publisher
Springer-Verlag
Published in
Acta Neuropathologica / Issue 5/2009
Print ISSN: 0001-6322
Electronic ISSN: 1432-0533
DOI
https://doi.org/10.1007/s00401-009-0483-6

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