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01-11-2011 | Original Contribution

Presence of endothelial colony-forming cells is associated with reduced microvascular obstruction limiting infarct size and left ventricular remodelling in patients with acute myocardial infarction

Authors: Nicolas Meneveau, Frédéric Deschaseaux, Marie-France Séronde, Romain Chopard, François Schiele, Jérome Jehl, Pierre Tiberghien, Jean-Pierre Bassand, Jean-Pierre Kantelip, Siamak Davani

Published in: Basic Research in Cardiology | Issue 6/2011

Abstract

Endothelial colony-forming cells (ECFCs) are known to increase after acute myocardial infarction (AMI). We examined whether the presence of ECFCs is associated with preserved microvascular integrity in the myocardium at risk by reducing microvascular obstruction (MVO). We enrolled 88 patients with a first ST elevation AMI. ECFC colonies and circulating progenitor cells were characterized at admission. MVO was evaluated at 5 days and infarct size at 5 days and at 6-month follow-up by magnetic resonance imaging. ECFC colonies were detected in 40 patients (ECFC^pos patients). At 5 days, MVO was of greater magnitude in ECFC^neg versus ECFC^pos patients (7.7 ± 5.3 vs. 3.2 ± 5%, p = 0.0002). At 6 months, in ECFC^pos patients, there was a greater reduction in infarct size (−32.4 ± 33 vs. −12.8 ± 24%; p = 0.003) and a significant improvement in left ventricular (LV) volumes and ejection fraction. Level of circulating CD34+/VEGF-R2+ cells was correlated with the number of ECFC colonies (r = 0.54, p < 0.001) and relative change in infarct size (r = 0.71, p < 0.0001). The results showed that the presence of ECFC colonies is associated with reduced MVO after AMI, leading to reduced infarct size and less LV remodelling and can be considered a marker of preserved microvascular integrity in AMI patients.

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Title: Presence of endothelial colony-forming cells is associated with reduced microvascular obstruction limiting infarct size and left ventricular remodelling in patients with acute myocardial infarction
Authors: Nicolas Meneveau
Frédéric Deschaseaux
Marie-France Séronde
Romain Chopard
François Schiele
Jérome Jehl
Pierre Tiberghien
Jean-Pierre Bassand
Jean-Pierre Kantelip
Siamak Davani
Publication date: 01-11-2011
Publisher: Springer-Verlag
Published in: Basic Research in Cardiology / Issue 6/2011
Print ISSN: 0300-8428
Electronic ISSN: 1435-1803
DOI: https://doi.org/10.1007/s00395-011-0220-x

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Presence of endothelial colony-forming cells is associated with reduced microvascular obstruction limiting infarct size and left ventricular remodelling in patients with acute myocardial infarction

Abstract

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Abstract

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