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Published in: European Journal of Nutrition 4/2013

01-06-2013 | Original Contribution

Dietary acrylamide intake of adults in the European Prospective Investigation into Cancer and Nutrition differs greatly according to geographical region

Authors: Heinz Freisling, Aurelie Moskal, Pietro Ferrari, Geneviève Nicolas, Viktoria Knaze, Françoise Clavel-Chapelon, Marie-Christine Boutron-Ruault, Laura Nailler, Birgit Teucher, Verena A. Grote, Heiner Boeing, Matthias Clemens, Anne Tjønneland, Anja Olsen, Kim Overvad, J. Ramón Quirós, Eric J. Duell, María-José Sánchez, Pilar Amiano, Maria-Dolores Chirlaque, Aurelio Barricarte, Kay-Tee Khaw, Nicholas J. Wareham, Francesca L. Crowe, Valentina Gallo, Eleni Oikonomou, Androniki Naska, Antonia Trichopoulou, Domenico Palli, Claudia Agnoli, Rosario Tumino, Silvia Polidoro, Amalia Mattiello, H. Bas Bueno-de-Mesquita, Marga C. Ocké, Petra H. M. Peeters, Elisabet Wirfält, Ulrika Ericson, Ingvar A. Bergdahl, Ingegerd Johansson, Anette Hjartåker, Dagrun Engeset, Guri Skeie, Elio Riboli, Nadia Slimani

Published in: European Journal of Nutrition | Issue 4/2013

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Abstract

Purpose

Methodological differences in assessing dietary acrylamide (AA) often hamper comparisons of intake across populations. Our aim was to describe the mean dietary AA intake in 27 centers of 10 European countries according to selected lifestyle characteristics and its contributing food sources in the European Prospective Investigation into Cancer and Nutrition (EPIC) study.

Methods

In this cross-sectional analysis, 36 994 men and women, aged 35–74 years completed a single, standardized 24-hour dietary recall using EPIC-Soft. Food consumption data were matched to a harmonized AA database. Intake was computed by gender and center, and across categories of habitual alcohol consumption, smoking status, physical activity, education, and body mass index (BMI). Adjustment was made for participants’ age, height, weight, and energy intake using linear regression models.

Results

Adjusted mean AA intake across centers ranged from 13 to 47 μg/day in men and from 12 to 39 μg/day in women; intakes were higher in northern European centers. In most centers, intake in women was significantly higher among alcohol drinkers compared with abstainers. There were no associations between AA intake and physical activity, BMI, or education. At least 50 % of AA intake across centers came from two food groups “bread, crisp bread, rusks” and “coffee.” The third main contributing food group was “potatoes”.

Conclusions

Dietary AA intake differs greatly among European adults residing in different geographical regions. This observed heterogeneity in AA intake deserves consideration in the design and interpretation of population-based studies of dietary AA intake and health outcomes.
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Literature
1.
go back to reference Parzefall W (2008) Minireview on the toxicity of dietary acrylamide. Food Chem Toxicol 46:1360–1364CrossRef Parzefall W (2008) Minireview on the toxicity of dietary acrylamide. Food Chem Toxicol 46:1360–1364CrossRef
2.
go back to reference Tareke E, Rydberg P, Karlsson P, Eriksson S, Tornqvist M (2002) Analysis of acrylamide, a carcinogen formed in heated foodstuffs. J Agric Food Chem 50:4998–5006CrossRef Tareke E, Rydberg P, Karlsson P, Eriksson S, Tornqvist M (2002) Analysis of acrylamide, a carcinogen formed in heated foodstuffs. J Agric Food Chem 50:4998–5006CrossRef
3.
go back to reference Smith CJ, Perfetti TA, Rumple MA, Rodgman A, Doolittle DJ (2000) “IARC group 2A carcinogens” reported in cigarette mainstream smoke. Food Chem Toxicol 38:371–383CrossRef Smith CJ, Perfetti TA, Rumple MA, Rodgman A, Doolittle DJ (2000) “IARC group 2A carcinogens” reported in cigarette mainstream smoke. Food Chem Toxicol 38:371–383CrossRef
4.
go back to reference International Agency for Research on Cancer (1995) Acrylamide. IARC Monogr Ser 60:1–45. IARC, Lyon, France International Agency for Research on Cancer (1995) Acrylamide. IARC Monogr Ser 60:1–45. IARC, Lyon, France
5.
go back to reference Tran NL, Barraj LM, Murphy MM, Bi X (2010) Dietary acrylamide exposure and hemoglobin adducts–National Health and Nutrition Examination Survey (2003–04). Food Chem Toxicol 48:3098–3108CrossRef Tran NL, Barraj LM, Murphy MM, Bi X (2010) Dietary acrylamide exposure and hemoglobin adducts–National Health and Nutrition Examination Survey (2003–04). Food Chem Toxicol 48:3098–3108CrossRef
6.
go back to reference Dybing E, Farmer PB, Andersen M, Fennell TR, Lalljie SP, Muller DJ, Olin S, Petersen BJ, Schlatter J et al (2005) Human exposure and internal dose assessments of acrylamide in food. Food Chem Toxicol 43:365–410CrossRef Dybing E, Farmer PB, Andersen M, Fennell TR, Lalljie SP, Muller DJ, Olin S, Petersen BJ, Schlatter J et al (2005) Human exposure and internal dose assessments of acrylamide in food. Food Chem Toxicol 43:365–410CrossRef
7.
go back to reference Konings EJ, Baars AJ, van Klaveren JD, Spanjer MC, Rensen PM, Hiemstra M, van Kooij JA, Peters PW (2003) Acrylamide exposure from foods of the Dutch population and an assessment of the consequent risks. Food Chem Toxicol 41:1569–1579CrossRef Konings EJ, Baars AJ, van Klaveren JD, Spanjer MC, Rensen PM, Hiemstra M, van Kooij JA, Peters PW (2003) Acrylamide exposure from foods of the Dutch population and an assessment of the consequent risks. Food Chem Toxicol 41:1569–1579CrossRef
8.
go back to reference Svensson K, Abramsson L, Becker W, Glynn A, Hellenas KE, Lind Y, Rosen J (2003) Dietary intake of acrylamide in Sweden. Food Chem Toxicol 41:1581–1586CrossRef Svensson K, Abramsson L, Becker W, Glynn A, Hellenas KE, Lind Y, Rosen J (2003) Dietary intake of acrylamide in Sweden. Food Chem Toxicol 41:1581–1586CrossRef
9.
go back to reference Slimani N, Ferrari P, Ocke M, Welch A, Boeing H, Liere M, Pala V, Amiano P, Lagiou A et al (2000) Standardization of the 24-hour diet recall calibration method used in the European Prospective Investigation into Cancer and Nutrition (EPIC): general concepts and preliminary results. Eur J Clin Nutr 54:900–917CrossRef Slimani N, Ferrari P, Ocke M, Welch A, Boeing H, Liere M, Pala V, Amiano P, Lagiou A et al (2000) Standardization of the 24-hour diet recall calibration method used in the European Prospective Investigation into Cancer and Nutrition (EPIC): general concepts and preliminary results. Eur J Clin Nutr 54:900–917CrossRef
10.
go back to reference Slimani N, Kaaks R, Ferrari P, Casagrande C, Clavel-Chapelon F, Lotze G, Kroke A, Trichopoulos D, Trichopoulou A et al (2002) European Prospective Investigation into Cancer and Nutrition (EPIC) calibration study: rationale, design and population characteristics. Public Health Nutr 5:1125–1145CrossRef Slimani N, Kaaks R, Ferrari P, Casagrande C, Clavel-Chapelon F, Lotze G, Kroke A, Trichopoulos D, Trichopoulou A et al (2002) European Prospective Investigation into Cancer and Nutrition (EPIC) calibration study: rationale, design and population characteristics. Public Health Nutr 5:1125–1145CrossRef
11.
go back to reference Vesper HW, Slimani N, Hallmans G, Tjonneland A, Agudo A, Benetou V, Bingham S, Boeing H, Boutron-Ruault MC et al (2008) Cross-sectional study on acrylamide hemoglobin adducts in subpopulations from the European Prospective Investigation into Cancer and Nutrition (EPIC) Study. J Agric Food Chem 56:6046–6053CrossRef Vesper HW, Slimani N, Hallmans G, Tjonneland A, Agudo A, Benetou V, Bingham S, Boeing H, Boutron-Ruault MC et al (2008) Cross-sectional study on acrylamide hemoglobin adducts in subpopulations from the European Prospective Investigation into Cancer and Nutrition (EPIC) Study. J Agric Food Chem 56:6046–6053CrossRef
12.
go back to reference Riboli E, Hunt KJ, Slimani N, Ferrari P, Norat T, Fahey M, Charrondiere UR, Hemon B, Casagrande C et al (2002) European Prospective Investigation into Cancer and Nutrition (EPIC): study populations and data collection. Public Health Nutr 5:1113–1124CrossRef Riboli E, Hunt KJ, Slimani N, Ferrari P, Norat T, Fahey M, Charrondiere UR, Hemon B, Casagrande C et al (2002) European Prospective Investigation into Cancer and Nutrition (EPIC): study populations and data collection. Public Health Nutr 5:1113–1124CrossRef
13.
go back to reference Ferrari P, Kaaks R, Fahey MT, Slimani N, Day NE, Pera G, Boshuizen HC, Roddam A, Boeing H et al (2004) Within- and between-cohort variation in measured macronutrient intakes, taking account of measurement errors, in the European Prospective Investigation into Cancer and Nutrition study. Am J Epidemiol 160:814–822CrossRef Ferrari P, Kaaks R, Fahey MT, Slimani N, Day NE, Pera G, Boshuizen HC, Roddam A, Boeing H et al (2004) Within- and between-cohort variation in measured macronutrient intakes, taking account of measurement errors, in the European Prospective Investigation into Cancer and Nutrition study. Am J Epidemiol 160:814–822CrossRef
14.
go back to reference Brustad M, Skeie G, Braaten T, Slimani N, Lund E (2003) Comparison of telephone vs face-to-face interviews in the assessment of dietary intake by the 24 h recall EPIC SOFT program–the Norwegian calibration study. Eur J Clin Nutr 57:107–113CrossRef Brustad M, Skeie G, Braaten T, Slimani N, Lund E (2003) Comparison of telephone vs face-to-face interviews in the assessment of dietary intake by the 24 h recall EPIC SOFT program–the Norwegian calibration study. Eur J Clin Nutr 57:107–113CrossRef
15.
go back to reference Slimani N, Deharveng G, Unwin I, Southgate DA, Vignat J, Skeie G, Salvini S, Parpinel M, Moller A et al (2007) The EPIC nutrient database project (ENDB): a first attempt to standardize nutrient databases across the 10 European countries participating in the EPIC study. Eur J Clin Nutr 61:1037–1056CrossRef Slimani N, Deharveng G, Unwin I, Southgate DA, Vignat J, Skeie G, Salvini S, Parpinel M, Moller A et al (2007) The EPIC nutrient database project (ENDB): a first attempt to standardize nutrient databases across the 10 European countries participating in the EPIC study. Eur J Clin Nutr 61:1037–1056CrossRef
16.
go back to reference Wareham NJ, Jakes RW, Rennie KL, Schuit J, Mitchell J, Hennings S, Day NE (2003) Validity and repeatability of a simple index derived from the short physical activity questionnaire used in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Public Health Nutr 6:407–413CrossRef Wareham NJ, Jakes RW, Rennie KL, Schuit J, Mitchell J, Hennings S, Day NE (2003) Validity and repeatability of a simple index derived from the short physical activity questionnaire used in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Public Health Nutr 6:407–413CrossRef
17.
go back to reference U.S.Food and Drug Administration (2011) Survey data on acrylamide in food: individual food products, 2002–2004 U.S.Food and Drug Administration (2011) Survey data on acrylamide in food: individual food products, 2002–2004
18.
go back to reference Slimani N, Fahey M, Welch AA, Wirfalt E, Stripp C, Bergstrom E, Linseisen J, Schulze MB, Bamia C et al (2002) Diversity of dietary patterns observed in the European Prospective Investigation into Cancer and Nutrition (EPIC) project. Public Health Nutr 5:1311–1328CrossRef Slimani N, Fahey M, Welch AA, Wirfalt E, Stripp C, Bergstrom E, Linseisen J, Schulze MB, Bamia C et al (2002) Diversity of dietary patterns observed in the European Prospective Investigation into Cancer and Nutrition (EPIC) project. Public Health Nutr 5:1311–1328CrossRef
19.
go back to reference Wirfalt E, McTaggart A, Pala V, Gullberg B, Frasca G, Panico S, Bueno-de-Mesquita HB, Peeters PH, Engeset D et al (2002) Food sources of carbohydrates in a European cohort of adults. Public Health Nutr 5:1197–1215CrossRef Wirfalt E, McTaggart A, Pala V, Gullberg B, Frasca G, Panico S, Bueno-de-Mesquita HB, Peeters PH, Engeset D et al (2002) Food sources of carbohydrates in a European cohort of adults. Public Health Nutr 5:1197–1215CrossRef
20.
go back to reference Dybing E, Sanner T (2003) Risk assessment of acrylamide in foods. Toxicol Sci 75:7–15CrossRef Dybing E, Sanner T (2003) Risk assessment of acrylamide in foods. Toxicol Sci 75:7–15CrossRef
21.
go back to reference Kaaks R, Riboli E (1997) Validation and calibration of dietary intake measurements in the EPIC project: methodological considerations. European Prospective Investigation into Cancer and Nutrition. Int J Epidemiol 26(Suppl 1):S15–S25 Kaaks R, Riboli E (1997) Validation and calibration of dietary intake measurements in the EPIC project: methodological considerations. European Prospective Investigation into Cancer and Nutrition. Int J Epidemiol 26(Suppl 1):S15–S25
22.
go back to reference Hogervorst JG, Baars BJ, Schouten LJ, Konings EJ, Goldbohm RA, van den Brandt PA (2010) The carcinogenicity of dietary acrylamide intake: a comparative discussion of epidemiological and experimental animal research. Crit Rev Toxicol 40:485–512CrossRef Hogervorst JG, Baars BJ, Schouten LJ, Konings EJ, Goldbohm RA, van den Brandt PA (2010) The carcinogenicity of dietary acrylamide intake: a comparative discussion of epidemiological and experimental animal research. Crit Rev Toxicol 40:485–512CrossRef
23.
go back to reference Wirfalt E, Paulsson B, Tornqvist M, Axmon A, Hagmar L (2008) Associations between estimated acrylamide intakes, and hemoglobin AA adducts in a sample from the Malmo diet and cancer cohort. Eur J Clin Nutr 62(3):314–323 Wirfalt E, Paulsson B, Tornqvist M, Axmon A, Hagmar L (2008) Associations between estimated acrylamide intakes, and hemoglobin AA adducts in a sample from the Malmo diet and cancer cohort. Eur J Clin Nutr 62(3):314–323
24.
go back to reference Wilson KM, Vesper HW, Tocco P, Sampson L, Rosen J, Hellenas KE, Tornqvist M, Willett WC (2009) Validation of a food frequency questionnaire measurement of dietary acrylamide intake using hemoglobin adducts of acrylamide and glycidamide. Cancer Causes Control 20:269–278CrossRef Wilson KM, Vesper HW, Tocco P, Sampson L, Rosen J, Hellenas KE, Tornqvist M, Willett WC (2009) Validation of a food frequency questionnaire measurement of dietary acrylamide intake using hemoglobin adducts of acrylamide and glycidamide. Cancer Causes Control 20:269–278CrossRef
25.
go back to reference Vikstrom AC, Wilson KM, Paulsson B, Athanassiadis I, Gronberg H, Adami HO, Adolfsson J, Mucci LA, Balter K, Tornqvist M (2010) Alcohol influence on acrylamide to glycidamide metabolism assessed with hemoglobin-adducts and questionnaire data. Food Chem Toxicol 48:820–824CrossRef Vikstrom AC, Wilson KM, Paulsson B, Athanassiadis I, Gronberg H, Adami HO, Adolfsson J, Mucci LA, Balter K, Tornqvist M (2010) Alcohol influence on acrylamide to glycidamide metabolism assessed with hemoglobin-adducts and questionnaire data. Food Chem Toxicol 48:820–824CrossRef
26.
go back to reference Authority European Food Safety (2011) Results on acrylamide levels in food from monitoring years 2007–2009 and exposure assessment. EFSA J 9(4):2133 Authority European Food Safety (2011) Results on acrylamide levels in food from monitoring years 2007–2009 and exposure assessment. EFSA J 9(4):2133
Metadata
Title
Dietary acrylamide intake of adults in the European Prospective Investigation into Cancer and Nutrition differs greatly according to geographical region
Authors
Heinz Freisling
Aurelie Moskal
Pietro Ferrari
Geneviève Nicolas
Viktoria Knaze
Françoise Clavel-Chapelon
Marie-Christine Boutron-Ruault
Laura Nailler
Birgit Teucher
Verena A. Grote
Heiner Boeing
Matthias Clemens
Anne Tjønneland
Anja Olsen
Kim Overvad
J. Ramón Quirós
Eric J. Duell
María-José Sánchez
Pilar Amiano
Maria-Dolores Chirlaque
Aurelio Barricarte
Kay-Tee Khaw
Nicholas J. Wareham
Francesca L. Crowe
Valentina Gallo
Eleni Oikonomou
Androniki Naska
Antonia Trichopoulou
Domenico Palli
Claudia Agnoli
Rosario Tumino
Silvia Polidoro
Amalia Mattiello
H. Bas Bueno-de-Mesquita
Marga C. Ocké
Petra H. M. Peeters
Elisabet Wirfält
Ulrika Ericson
Ingvar A. Bergdahl
Ingegerd Johansson
Anette Hjartåker
Dagrun Engeset
Guri Skeie
Elio Riboli
Nadia Slimani
Publication date
01-06-2013
Publisher
Springer-Verlag
Published in
European Journal of Nutrition / Issue 4/2013
Print ISSN: 1436-6207
Electronic ISSN: 1436-6215
DOI
https://doi.org/10.1007/s00394-012-0446-x

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