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01-03-2014 | Original Paper

Association of high-sensitivity assayed troponin I with cardiovascular phenotypes in the general population: the population-based Gutenberg health study

Authors: Christoph Sinning, Till Keller, Tanja Zeller, Francisco Ojeda, Michael Schlüter, Renate Schnabel, Edith Lubos, Christoph Bickel, Karl J. Lackner, Patrick Diemert, Thomas Munzel, Stefan Blankenberg, Philipp S. Wild, for the Gutenberg Health Study

Published in: Clinical Research in Cardiology | Issue 3/2014

Abstract

Background

Aim of the study was to analyze the correlation of high-sensitivity assayed troponin I with cardiac and vascular structure and function in a large population-based cohort.

Methods

In a sample of 4,139 subjects (2,099 men, 2,040 women, age 35–74 years) from the population-based Gutenberg Health Study, troponin I was measured with a high-sensitivity assay that had a limit of detection of 1.9 pg/mL.

Results

In the study cohort, 3,405 subjects had detectable troponin I concentrations [82.3 % overall, 89.9 % men (N = 1,888), 74.4 % women (N = 1,517)]. All analyses were adjusted for age. The strongest correlate between detectable troponin I and measures of cardiac phenotypes was observed for left ventricular mass (p < 0.001) and left ventricular end-diastolic diameter (p < 0.001) for both, women and men. Left ventricular ejection fraction was inversely correlated with troponin I (p value <0.001 in men and 0.0013 in women), also measures of diastolic dysfunction as represented by Tei index and E/E′ correlated with detectable troponin I concentrations (p < 0.001 for both gender). With respect to vascular structure and function, troponin I correlated with mean intima-media thickness of the carotid artery (p < 0.001 in men and p = 0.013 in women) but showed only borderline correlation with measures of vascular function represented by flow-mediated dilation (p = 0.05 in women and p = 0.018 in men) and arterial stiffness.

Conclusions

Troponin I assessed by a high-sensitivity assay correlated with measures of left ventricular hypertrophy and systolic and diastolic function, whereas its correlation with vascular phenotypes was only of weak magnitude.

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Title: Association of high-sensitivity assayed troponin I with cardiovascular phenotypes in the general population: the population-based Gutenberg health study
Authors: Christoph Sinning
Till Keller
Tanja Zeller
Francisco Ojeda
Michael Schlüter
Renate Schnabel
Edith Lubos
Christoph Bickel
Karl J. Lackner
Patrick Diemert
Thomas Munzel
Stefan Blankenberg
Philipp S. Wild
for the Gutenberg Health Study
Publication date: 01-03-2014
Publisher: Springer Berlin Heidelberg
Published in: Clinical Research in Cardiology / Issue 3/2014
Print ISSN: 1861-0684
Electronic ISSN: 1861-0692
DOI: https://doi.org/10.1007/s00392-013-0640-8

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Association of high-sensitivity assayed troponin I with cardiovascular phenotypes in the general population: the population-based Gutenberg health study

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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