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01-04-2013 | Original Paper

Generic and disease-specific health-related quality of life in patients with chronic systolic heart failure: impact of depression

Authors: Marion Schowalter, Götz Gelbrich, Stefan Störk, Jan-Philip Langguth, Caroline Morbach, Georg Ertl, Hermann Faller, Christiane E. Angermann

Published in: Clinical Research in Cardiology | Issue 4/2013

Abstract

Aims

Heart failure is known to profoundly affect health-related quality of life (HRQoL). We aimed to describe both generic and disease-specific HRQoL in a large community-based sample of patients with systolic heart failure (SHF) and to identify important somatic and psychosocial correlates.

Methods and results

Seven hundred and two patients, 67 ± 12 years old, 71 % men, with distributions of New York Heart Association (NYHA) functional classes I/II/III/IV of 2/55/39/4 % were included in this cross-sectional analysis. Generic HRQoL was measured with the SF-36 health survey, disease-specific HRQoL with the Kansas City Cardiomyopathy Questionnaire, and depression with the self-reported Patient Health Questionnaire (PHQ-9). Both generic- and disease-specific HRQoL measurements indicated moderate to poor HRQoL. The KCCQ scores demonstrated higher sensitivity to the varying levels of heart failure severity as compared to the SF-36 scores. Patients with either a minor (15 %) or a major depression (24 %) reported significantly and substantially lower HRQoL (p < .001) than patients without depression did. In multivariable regression analyses, depression accounted for the largest part of the variance of both generic and specific HRQoL (12 and 36 %, respectively), whereas most biomedical variables had no or only a marginal influence.

Conclusion

Patients with SHF suffer from severe limitations of HRQoL. Depression was the most important correlate of both generic and disease-specific HRQoL.

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Title: Generic and disease-specific health-related quality of life in patients with chronic systolic heart failure: impact of depression
Authors: Marion Schowalter
Götz Gelbrich
Stefan Störk
Jan-Philip Langguth
Caroline Morbach
Georg Ertl
Hermann Faller
Christiane E. Angermann
Publication date: 01-04-2013
Publisher: Springer-Verlag
Published in: Clinical Research in Cardiology / Issue 4/2013
Print ISSN: 1861-0684
Electronic ISSN: 1861-0692
DOI: https://doi.org/10.1007/s00392-012-0531-4

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Generic and disease-specific health-related quality of life in patients with chronic systolic heart failure: impact of depression

Abstract

Aims

Methods and results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Aims

Methods and results

Conclusion

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