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Clinical Research in Cardiology

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01-03-2010 | Original Paper

Intravascular ultrasound study and evidence of pathological coronary flow reserve in patients with isolated coronary artery aneurysms

Authors: Dietmar Krüger, Nour Eddine ElMokhtari, Arne Wieckhorst, Gunhild Simon-Herrmann, Rüdiger Simon

Published in: Clinical Research in Cardiology | Issue 3/2010

Abstract

Objectives

Isolated coronary artery aneurysms (CA) are defined as non-obstructive lesions with luminal dilation ≥2-fold of normal coronary diameters.

Methods

A coronary sinus study with incremental atrial pacing was performed in 19 patients with bilateral fusiform CA to investigate myocardial ischemia. Intravascular ultrasound was performed to characterize the lesions morphology. The average peak velocity in the aneurysmatic segment of the left anterior descending artery was simultaneously measured by a Doppler flow wire. Coronary flow volumes, vascular resistances and flow reserve after administration of papaverin were calculated. Ten patients without heart disease served as a control group (CG).

Results

Intravascular ultrasound revealed large true CA with a cross-sectional area of 34.2 ± 4.1 mm² and only slight atherosclerosis. Exercise-induced myocardial ischemia was found in CA presenting with a cardiac lactate production and an only 1.6-fold increase in coronary blood flow. A significant smaller coronary flow reserve of 1.51 was revealed in CA when compared with CG (2.86, P < 0.02) corresponding to a coronary vascular resistance of 0.59 versus 0.35 (P < 0.03) mmHg (ml/min) after papaverin.

Conclusions

Coronary artery aneurysms were unequivocally identified as an entity of ischemic non-obstructive coronary artery disease with a markedly reduced flow reserve.

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Title: Intravascular ultrasound study and evidence of pathological coronary flow reserve in patients with isolated coronary artery aneurysms
Authors: Dietmar Krüger
Nour Eddine ElMokhtari
Arne Wieckhorst
Gunhild Simon-Herrmann
Rüdiger Simon
Publication date: 01-03-2010
Publisher: Springer-Verlag
Published in: Clinical Research in Cardiology / Issue 3/2010
Print ISSN: 1861-0684
Electronic ISSN: 1861-0692
DOI: https://doi.org/10.1007/s00392-009-0100-7

2024 ASCO Annual Meeting

Springer Medicine

Intravascular ultrasound study and evidence of pathological coronary flow reserve in patients with isolated coronary artery aneurysms

Abstract

Objectives

Methods

Results

Conclusions

2024 ASCO Annual Meeting

Springer Medicine

Abstract

Objectives

Methods

Results

Conclusions

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