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International Journal of Colorectal Disease

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01-09-2020 | Rectal Cancer | Original Article

The prognostic value of organ/space surgical site infection in stage I colorectal cancer recurrence

Authors: Shintaro Akabane, Hiroyuki Egi, Yuji Takakura, Haruki Sada, Masatoshi Kochi, Kazuhiro Taguchi, Ikki Nakashima, Yusuke Sumi, Koki Sato, Hisaaki Yoshinaka, Minoru Hattori, Hideki Ohdan

Published in: International Journal of Colorectal Disease | Issue 9/2020

Abstract

Purpose

Evidence on risk factors for postoperative recurrence in patients with colorectal cancer (CRC) confined to pathological stage I is limited. Therefore, this study aimed to identify the risk factors for recurrence in patients with stage I CRC.

Methods

Data on clinicopathological factors and blood tests of patients diagnosed with pathological stage I CRC at Hiroshima University Hospital between April 1, 2010, and December 31, 2018, were retrospectively obtained. The statistical significance between the clinical factors and postoperative recurrence was also investigated.

Results

A total of 244 patients were included. The median observation period was 45 months. There were 17 patients (6.6%) with a postoperative recurrence (8 local and 9 distant recurrences). In the log-lank test, rectal cancer (p = 0.004), pT2 (p = 0.020) and organ/space surgical site infection (SSI) (p = 0.008) were significantly associated with postoperative recurrence. In a multivariate analysis, rectal cancer (hazard ratio [HR] 3.678, 95% confidence interval [CI] 1.184–11.425, p = 0.024) and organ/space SSI (HR 3.137, 95% CI 1.013–9.713, p = 0.047) were independently associated with a higher recurrence rate. Among 18 patients with organ/space SSI, 4 recurrences occurred, all of which were distant metastases.

Conclusion

Organ/space SSI significantly affects the postoperative recurrence in patients with stage I CRC.

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Title: The prognostic value of organ/space surgical site infection in stage I colorectal cancer recurrence
Authors: Shintaro Akabane
Hiroyuki Egi
Yuji Takakura
Haruki Sada
Masatoshi Kochi
Kazuhiro Taguchi
Ikki Nakashima
Yusuke Sumi
Koki Sato
Hisaaki Yoshinaka
Minoru Hattori
Hideki Ohdan
Publication date: 01-09-2020
Publisher: Springer Berlin Heidelberg
Keywords: Rectal Cancer
Rectal Cancer
Colorectal Cancer
Colorectal Cancer
Published in: International Journal of Colorectal Disease / Issue 9/2020
Print ISSN: 0179-1958
Electronic ISSN: 1432-1262
DOI: https://doi.org/10.1007/s00384-020-03643-6

Keynote webinar | Spotlight on medication adherence

Springer Medicine

The prognostic value of organ/space surgical site infection in stage I colorectal cancer recurrence

Abstract

Purpose

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

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