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International Journal of Colorectal Disease

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01-08-2015 | Original Article

Diagnostic value of preoperative CT scan to stratify colon cancer for neoadjuvant therapy

Authors: Armin Wiegering, Meik Kunz, Mohamed Hussein, Ingo Klein, Verena Wiegering, Friedrich Wilhelm Uthe, Ulrich A. Dietz, Christian Jurowich, Thorsten Bley, Thomas Dandekar, Christoph-Thomas Germer, Christian Ritter

Published in: International Journal of Colorectal Disease | Issue 8/2015

Abstract

Background and objective

Neoadjuvant therapy could improve oncological outcome of patients suffering from colon cancer. An accurate staging method is needed to define suitable patients. The aim of this retrospective study was to validate the value of CT for identifying patients with local advanced (T3/4) or nodal-positive colon cancer.

Methods and material

Preoperative abdominal CT scans of 210 patients with colon cancer were evaluated by two radiologists independently for the T stage and N stage. Results were compared to pathology. Patients were stratified according to the guidelines for rectal cancer into patients with low risk (T0/1/2 and N0) or high risk (T3/4 or N+).

Results

Inter-observer correlation was high with over 90 %. Overall sensitivity T stage was 93.0 % and for N stage 76.9 %. Using CT scan to identify local advanced (T3/4 or N+) tumors, the consensus sensitivity was 94.9 %, the specificity 53.6 %, the positive predictive value (PPV) 92.8 %, and the negative predictive value (NPV) 62.5 %.

Conclusion

Computer tomography represents an effective tool for identifying patients with colon cancer suitable for neoadjuvant therapy according to the guidelines for rectal cancer.

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Title: Diagnostic value of preoperative CT scan to stratify colon cancer for neoadjuvant therapy
Authors: Armin Wiegering
Meik Kunz
Mohamed Hussein
Ingo Klein
Verena Wiegering
Friedrich Wilhelm Uthe
Ulrich A. Dietz
Christian Jurowich
Thorsten Bley
Thomas Dandekar
Christoph-Thomas Germer
Christian Ritter
Publication date: 01-08-2015
Publisher: Springer Berlin Heidelberg
Published in: International Journal of Colorectal Disease / Issue 8/2015
Print ISSN: 0179-1958
Electronic ISSN: 1432-1262
DOI: https://doi.org/10.1007/s00384-015-2265-z

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Diagnostic value of preoperative CT scan to stratify colon cancer for neoadjuvant therapy

Abstract

Background and objective

Methods and material

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background and objective

Methods and material

Results

Conclusion

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