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Published in: International Journal of Colorectal Disease 1/2013

01-01-2013 | Original Article

Fast-track colorectal surgery: protocol adherence influences postoperative outcomes

Authors: Francesco Feroci, Elisa Lenzi, Maddalena Baraghini, Alessia Garzi, Andrea Vannucchi, Stefano Cantafio, Marco Scatizzi

Published in: International Journal of Colorectal Disease | Issue 1/2013

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Abstract

Purpose

This single-center prospective cohort study, conducted outside of a clinical trial, tried to identify the importance of each fast-track surgery procedure and protocol adherence level on clinical outcomes after colorectal surgery.

Methods

From a prospectively maintained database, 606 patients who underwent elective laparoscopic or open colorectal resection within a well established fast-track surgery (FT) protocol, between 2005 and 2011, were identified. Univariate and multivariate analysis were performed to assess the relationship between each FT procedure with an adherence rate <100 % and the outcome variables (length of stay—LOS, 30-day morbidity and readmission rate). Patients were divided into four adherence level groups to FT procedures—100 %, 85–95 %,70–80 %, and <65 %. Each adherence group was compared with the other groups to evaluate differences in clinical outcome variables.

Results

Group comparisons revealed that higher levels of FT protocol adherence corresponded to significantly improved LOS and morbidity rates. Readmission rates were only significantly different between the full fast-track pathway and the less implemented groups. Multivariate analyses revealed that the fast removal of bladder catheter positively influenced length of stay (p < 0.0001) and 30-day morbidity (p < 0.0001). Laparoscopy surgery, no drain positioning and enforced mobilization improved LOS (p = 0.027, p < 0.0001, p = 0.002, respectively). Early solid feeding improved LOS (p < 0.0001), morbidity (p < 0.0001) and readmission rate (p = 0.011).

Conclusion

Postoperative outcomes after colorectal surgery are directly proportional to FT protocol adherence. The early removal of the bladder catheter and early postoperative solid feeding independently influenced the length of hospital stay and 30-day morbidity rates.
Literature
1.
go back to reference Slim K (2011) Fast-track surgery: the next revolution in surgical care following laparoscopy. Colorectal Dis 13(5):478–480PubMedCrossRef Slim K (2011) Fast-track surgery: the next revolution in surgical care following laparoscopy. Colorectal Dis 13(5):478–480PubMedCrossRef
2.
go back to reference Lassen K, Soop M, Nygren J, Cox PB, Hendry PO, Spies C, von Meyenfeldt MF, Fearon KC, Revhaug A, Norderval S, Ljungqvist O, Lobo DN, Dejong CH, Enhanced Recovery After Surgery (ERAS) Group (2009) Consensus review of optimal perioperative care in colorectal surgery: Enhanced Recovery After Surgery (ERAS) Group recommendations. Arch Surg 144(10):961–969PubMedCrossRef Lassen K, Soop M, Nygren J, Cox PB, Hendry PO, Spies C, von Meyenfeldt MF, Fearon KC, Revhaug A, Norderval S, Ljungqvist O, Lobo DN, Dejong CH, Enhanced Recovery After Surgery (ERAS) Group (2009) Consensus review of optimal perioperative care in colorectal surgery: Enhanced Recovery After Surgery (ERAS) Group recommendations. Arch Surg 144(10):961–969PubMedCrossRef
3.
go back to reference Raue W, Haase O, Junghans T, Scharfenberg M, Muller JM, Schwenk W (2004) ‘Fast-track’ multimodal rehabilitation program improves outcome after laparoscopic sigmoidectomy: a controlled prospective evaluation. Surg Endosc 18:1463–8.45PubMedCrossRef Raue W, Haase O, Junghans T, Scharfenberg M, Muller JM, Schwenk W (2004) ‘Fast-track’ multimodal rehabilitation program improves outcome after laparoscopic sigmoidectomy: a controlled prospective evaluation. Surg Endosc 18:1463–8.45PubMedCrossRef
4.
go back to reference Basse L, Jakobsen DH, Bardram (2005) Functional recovery after open versus laparoscopic colonic resection: a randomized, blinded study. Ann Surg 241:416–423PubMedCrossRef Basse L, Jakobsen DH, Bardram (2005) Functional recovery after open versus laparoscopic colonic resection: a randomized, blinded study. Ann Surg 241:416–423PubMedCrossRef
5.
go back to reference King PM, Blazeby JM, Ewings P (2006) The influence of an enhanced recovery programme on clinical outcomes, costs and quality of life after surgery for colorectal cancer. Colorectal Dis 8:506–513PubMedCrossRef King PM, Blazeby JM, Ewings P (2006) The influence of an enhanced recovery programme on clinical outcomes, costs and quality of life after surgery for colorectal cancer. Colorectal Dis 8:506–513PubMedCrossRef
6.
go back to reference Basse L, Thorbol JE, Lossl K, Kehlet H (2004) Colonic surgery with accelerated rehabilitation or conventional care. Dis Colon Rectum 47:271–277PubMedCrossRef Basse L, Thorbol JE, Lossl K, Kehlet H (2004) Colonic surgery with accelerated rehabilitation or conventional care. Dis Colon Rectum 47:271–277PubMedCrossRef
7.
go back to reference Gatt M, Anderson AD, Reddy BS, Hayward-Sampson P, Tring IC, MacFie J (2005) Randomized clinical trial of multimodal optimization of surgical care in patients undergoing major colonic resection. Br J Surg 92:1354–1362PubMedCrossRef Gatt M, Anderson AD, Reddy BS, Hayward-Sampson P, Tring IC, MacFie J (2005) Randomized clinical trial of multimodal optimization of surgical care in patients undergoing major colonic resection. Br J Surg 92:1354–1362PubMedCrossRef
8.
go back to reference Khoo CK, Vickery CJ, Forsyth N, Vinall NS, Eyre-Brook IA (2007) A prospective randomized controlled trial of multimodal perioperative management protocol in patients undergoing elective colorectal resection for cancer. Ann Surg 245:867–872PubMedCrossRef Khoo CK, Vickery CJ, Forsyth N, Vinall NS, Eyre-Brook IA (2007) A prospective randomized controlled trial of multimodal perioperative management protocol in patients undergoing elective colorectal resection for cancer. Ann Surg 245:867–872PubMedCrossRef
9.
go back to reference Muller S, Zalunardo MP, Hubner M, Clavien PA, Demartines N (2009) A fast-track program reduces complications and length of hospital stay after open colonic surgery. Gastroenterology 136:842–847PubMedCrossRef Muller S, Zalunardo MP, Hubner M, Clavien PA, Demartines N (2009) A fast-track program reduces complications and length of hospital stay after open colonic surgery. Gastroenterology 136:842–847PubMedCrossRef
10.
go back to reference Serclova Z, Dytrych P, Marvan J et al (2009) Fast-track in open intestinal surgery: prospective randomized study (Clinical Trials Gov Identifier no. NCT00123456). Clin Nutr 28:618–624PubMedCrossRef Serclova Z, Dytrych P, Marvan J et al (2009) Fast-track in open intestinal surgery: prospective randomized study (Clinical Trials Gov Identifier no. NCT00123456). Clin Nutr 28:618–624PubMedCrossRef
11.
go back to reference Delaney CP, Zutshi M, Senagore AJ, Remzi FH, Hammel J, Fazio VW (2003) Prospective, randomized, controlled trial between a pathway of controlled rehabilitation with early ambulation and diet and traditional postoperative care after laparotomy and intestinal resection. Dis Colon Rectum 46:851–859PubMedCrossRef Delaney CP, Zutshi M, Senagore AJ, Remzi FH, Hammel J, Fazio VW (2003) Prospective, randomized, controlled trial between a pathway of controlled rehabilitation with early ambulation and diet and traditional postoperative care after laparotomy and intestinal resection. Dis Colon Rectum 46:851–859PubMedCrossRef
12.
go back to reference Anderson AD, McNaught CE, MacFie J, Tring I, Barker P, Mitchell CJ (2003) Randomized clinical trial of multimodal optimization and standard perioperative surgical care. Br J Surg 90:1497–1504PubMedCrossRef Anderson AD, McNaught CE, MacFie J, Tring I, Barker P, Mitchell CJ (2003) Randomized clinical trial of multimodal optimization and standard perioperative surgical care. Br J Surg 90:1497–1504PubMedCrossRef
13.
go back to reference Spanjersberg WR, Reurings J, Keus F, van Laarhoven CJ (2011) Fast track surgery versus conventional recovery strategies for colorectal surgery. Cochrane Database Syst Rev. Feb 16(2): Spanjersberg WR, Reurings J, Keus F, van Laarhoven CJ (2011) Fast track surgery versus conventional recovery strategies for colorectal surgery. Cochrane Database Syst Rev. Feb 16(2):
14.
go back to reference Maessen J, Dejong CH, Hausel J, Nygren J, Lassen K, Anderson J (2007) A protocol is not enough to implement an enhanced recovery programme for colorectal resection. Br J Surg 94:224–231PubMedCrossRef Maessen J, Dejong CH, Hausel J, Nygren J, Lassen K, Anderson J (2007) A protocol is not enough to implement an enhanced recovery programme for colorectal resection. Br J Surg 94:224–231PubMedCrossRef
15.
go back to reference Ahmed J, Khan S, Gatt M, Kallam R, MacFie J (2010) Compliance with enhanced recovery programmes in elective colorectal surgery. Br J Surg 97(5):754–758PubMedCrossRef Ahmed J, Khan S, Gatt M, Kallam R, MacFie J (2010) Compliance with enhanced recovery programmes in elective colorectal surgery. Br J Surg 97(5):754–758PubMedCrossRef
16.
go back to reference Lassen K, Hannemann P, Ljungqvist O, Fearon K, Dejong CH, von Meyenfeldt MF, Hausel J, Nygren J, Andersen J, Revhaug A, Enhanced Recovery After Surgery Group (2005) Patterns in current perioperative practice: survey of colorectal surgeons in five northern European countries. BMJ 330(7505):1420–1421PubMedCrossRef Lassen K, Hannemann P, Ljungqvist O, Fearon K, Dejong CH, von Meyenfeldt MF, Hausel J, Nygren J, Andersen J, Revhaug A, Enhanced Recovery After Surgery Group (2005) Patterns in current perioperative practice: survey of colorectal surgeons in five northern European countries. BMJ 330(7505):1420–1421PubMedCrossRef
17.
go back to reference Fearon KC, Ljungqvist O, Von Meyenfeldt M, Revhaug A, Dejong CH, Lassen K, Nygren J, Hausel J, Soop M, Andersen J, Kehlet H (2005) Enhanced recovery aftersurgery: a consensus review of clinical care for patients undergoing colonic resection. Clin Nutr 24(3):466–477PubMedCrossRef Fearon KC, Ljungqvist O, Von Meyenfeldt M, Revhaug A, Dejong CH, Lassen K, Nygren J, Hausel J, Soop M, Andersen J, Kehlet H (2005) Enhanced recovery aftersurgery: a consensus review of clinical care for patients undergoing colonic resection. Clin Nutr 24(3):466–477PubMedCrossRef
18.
go back to reference Feroci F, Kröning KC, Lenzi E, Moraldi L, Cantafio S, Scatizzi M (2011) Laparoscopy within a fast-track program enhances the short-term results after elective surgery for resectable colorectal cancer. Surg Endosc 25(9):2919–2925PubMedCrossRef Feroci F, Kröning KC, Lenzi E, Moraldi L, Cantafio S, Scatizzi M (2011) Laparoscopy within a fast-track program enhances the short-term results after elective surgery for resectable colorectal cancer. Surg Endosc 25(9):2919–2925PubMedCrossRef
19.
go back to reference Scatizzi M, Kröning KC, Boddi V, De Prizio M, Feroci F (2010) Fast-track surgery after laparoscopic colorectal surgery: is it feasible in a general surgery unit? Surgery 147(2):219–226PubMedCrossRef Scatizzi M, Kröning KC, Boddi V, De Prizio M, Feroci F (2010) Fast-track surgery after laparoscopic colorectal surgery: is it feasible in a general surgery unit? Surgery 147(2):219–226PubMedCrossRef
20.
go back to reference Gustafsson UO, Hausel J, Thorell A, Ljungqvist O, Soop M, Nygren J, Enhanced Recovery After Surgery Study Group (2011) Adherence to the enhanced recovery after surgery protocol and outcomes after colorectal cancer surgery. Arch Surg 146(5):571–577PubMedCrossRef Gustafsson UO, Hausel J, Thorell A, Ljungqvist O, Soop M, Nygren J, Enhanced Recovery After Surgery Study Group (2011) Adherence to the enhanced recovery after surgery protocol and outcomes after colorectal cancer surgery. Arch Surg 146(5):571–577PubMedCrossRef
21.
go back to reference Vlug MS, Wind J, Wind J, van der Zaag E, Ubbink DT, Cense HA, Bemelman WA (2009) Systematic review of laparoscopic versus open colonic surgery within an enhanced recovery programme. Colorectal Dis 11:335–343PubMedCrossRef Vlug MS, Wind J, Wind J, van der Zaag E, Ubbink DT, Cense HA, Bemelman WA (2009) Systematic review of laparoscopic versus open colonic surgery within an enhanced recovery programme. Colorectal Dis 11:335–343PubMedCrossRef
22.
go back to reference Polle SW, Wind J, Fuhring JW, Hofland J, Gouma DJ, Bemelman WA (2007) Implementation of a fast-track perioperative care program: what are the difficulties? Dig Surg 24:441–449PubMedCrossRef Polle SW, Wind J, Fuhring JW, Hofland J, Gouma DJ, Bemelman WA (2007) Implementation of a fast-track perioperative care program: what are the difficulties? Dig Surg 24:441–449PubMedCrossRef
23.
go back to reference Soop M, Nygren J, Ljungqvist O (2006) Optimizing perioperative management of patients undergoing colorectal surgery: what is new? Curr Opin Crit Care 12:166–170PubMedCrossRef Soop M, Nygren J, Ljungqvist O (2006) Optimizing perioperative management of patients undergoing colorectal surgery: what is new? Curr Opin Crit Care 12:166–170PubMedCrossRef
24.
go back to reference Walter CJ, Smith A, Guillou P (2006) Perceptions of the application of fast-track surgical principles by generalsurgeons. Ann R Coll Surg Engl 88:191–195PubMedCrossRef Walter CJ, Smith A, Guillou P (2006) Perceptions of the application of fast-track surgical principles by generalsurgeons. Ann R Coll Surg Engl 88:191–195PubMedCrossRef
25.
go back to reference Kahokehr A, Sammour T, Zargar-Shoshtari K, Thompson LG, Hill AG (2009) Implementation of ERAS and how to overcome the barriers. Int J Surg 7:16–19PubMedCrossRef Kahokehr A, Sammour T, Zargar-Shoshtari K, Thompson LG, Hill AG (2009) Implementation of ERAS and how to overcome the barriers. Int J Surg 7:16–19PubMedCrossRef
26.
go back to reference Hendry PO, Hausel J, Nygren J, Lassen K, Dejong CH, Ljungqvist O, Fearon KC, Enhanced Recovery After Surgery Study Group (2009) Determinants of outcome after colorectal resection within an enhanced recovery programme. Br J Surg 96(2):197–205PubMedCrossRef Hendry PO, Hausel J, Nygren J, Lassen K, Dejong CH, Ljungqvist O, Fearon KC, Enhanced Recovery After Surgery Study Group (2009) Determinants of outcome after colorectal resection within an enhanced recovery programme. Br J Surg 96(2):197–205PubMedCrossRef
27.
go back to reference Adamina M, Kehlet H, Tomlinson GA, Senagore AJ, Delaney CP (2011) Enhanced recovery pathways optimize health outcomes and resource utilization: a meta-analysis of randomized controlled trials in colorectal surgery. Surgery 149(6):830–840PubMedCrossRef Adamina M, Kehlet H, Tomlinson GA, Senagore AJ, Delaney CP (2011) Enhanced recovery pathways optimize health outcomes and resource utilization: a meta-analysis of randomized controlled trials in colorectal surgery. Surgery 149(6):830–840PubMedCrossRef
28.
go back to reference Vlug MS, Wind J, Hollmann MW, Ubbink DT, Cense HA, Engel AF, Gerhards MF, van Wagensveld BA, van der Zaag ES, van Geloven AA, Sprangers MA, Cuesta MA, Bemelman WA, LAFA study group (2011) Laparoscopy in combination with fast track multimodal management is the best perioperative strategy in patients undergoing colonic surgery: a randomized clinical Trial (LAFA-study). Ann Surg 254(6):868–875PubMedCrossRef Vlug MS, Wind J, Hollmann MW, Ubbink DT, Cense HA, Engel AF, Gerhards MF, van Wagensveld BA, van der Zaag ES, van Geloven AA, Sprangers MA, Cuesta MA, Bemelman WA, LAFA study group (2011) Laparoscopy in combination with fast track multimodal management is the best perioperative strategy in patients undergoing colonic surgery: a randomized clinical Trial (LAFA-study). Ann Surg 254(6):868–875PubMedCrossRef
29.
go back to reference Basse L, Werner M, Kehlet H (2000) Is urinary drainage necessary during continuous epidural analgesia after colonic resection? Reg Anesth Pain Med 25(5):498–501PubMed Basse L, Werner M, Kehlet H (2000) Is urinary drainage necessary during continuous epidural analgesia after colonic resection? Reg Anesth Pain Med 25(5):498–501PubMed
30.
go back to reference Andersen HK, Lewis SJ, Thomas S (2006) Early enteral nutrition within 24 h of colorectal surgery versus later commencement of feeding for postoperative complications. Cochrane Database Syst Rev. CD004080 Andersen HK, Lewis SJ, Thomas S (2006) Early enteral nutrition within 24 h of colorectal surgery versus later commencement of feeding for postoperative complications. Cochrane Database Syst Rev. CD004080
Metadata
Title
Fast-track colorectal surgery: protocol adherence influences postoperative outcomes
Authors
Francesco Feroci
Elisa Lenzi
Maddalena Baraghini
Alessia Garzi
Andrea Vannucchi
Stefano Cantafio
Marco Scatizzi
Publication date
01-01-2013
Publisher
Springer-Verlag
Published in
International Journal of Colorectal Disease / Issue 1/2013
Print ISSN: 0179-1958
Electronic ISSN: 1432-1262
DOI
https://doi.org/10.1007/s00384-012-1569-5

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