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International Journal of Colorectal Disease

Published in:

01-07-2009 | Original Article

Plasminogen fragment K1–3 inhibits expression of adhesion molecules and experimental HCC recurrence in the liver

Authors: Esther Raskopf, Sevil Gerceker, Annabelle Vogt, Jens Standop, Tilman Sauerbruch, Volker Schmitz

Published in: International Journal of Colorectal Disease | Issue 7/2009

Abstract

Purpose

There is no established adjuvant or neo-adjuvant treatment to curb tumor recurrence of hepatocellular carcinoma (HCC). Recent data showed that angiostatic factors can inhibit tumor cell adhesion to the endothelium and therefore recurrence/metastasis. We tested a potential preventive, pre-operative strategy using plasminogen kringles 1–3 (K1–3) to overcome this hurdle.

Materials and methods

Effects of K1–3 on the intercellular cell adhesion molecule (ICAM) and vascular cell adhesion molecule (VCAM) expression was analyzed in vitro and in vivo on RNA and protein levels. Influence of K1–3 on HCC recurrence in the liver was analyzed in an orthotopic tumor model.

Results

K1–3 decreased ICAM expression in Hepa129 tumor cells and VCAM expression in SVEC4-10 endothelial cells in vitro. In vivo, ICAM was reduced in histological tumor sections. Preventive treatment with AdK1–3 inhibited experimental HCC recurrence and tumor growth in the liver.

Conclusions

We were able to show that K1–3 inhibits intrahepatic tumor recurrence. This novel aspect elucidates a possible approach to prevent HCC recurrence.

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Title: Plasminogen fragment K1–3 inhibits expression of adhesion molecules and experimental HCC recurrence in the liver
Authors: Esther Raskopf
Sevil Gerceker
Annabelle Vogt
Jens Standop
Tilman Sauerbruch
Volker Schmitz
Publication date: 01-07-2009
Publisher: Springer-Verlag
Published in: International Journal of Colorectal Disease / Issue 7/2009
Print ISSN: 0179-1958
Electronic ISSN: 1432-1262
DOI: https://doi.org/10.1007/s00384-009-0652-z

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Plasminogen fragment K1–3 inhibits expression of adhesion molecules and experimental HCC recurrence in the liver

Abstract

Purpose

Materials and methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Materials and methods

Results

Conclusions

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