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International Journal of Colorectal Disease

Published in:

01-03-2009 | Original Article

Sodium hyaluronate-based bioresorbable membrane (Seprafilm^®) reduced early postoperative intestinal obstruction after lower abdominal surgery for colorectal cancer: the preliminary report

Authors: Chi-Min Park, Woo Yong Lee, Yong Beom Cho, Hae Ran Yun, Won-Suk Lee, Seong Hyeon Yun, Ho-Kyung Chun

Published in: International Journal of Colorectal Disease | Issue 3/2009

Abstract

Purposes

This study is a prospective randomized clinical trial to evaluate the clinical safety and the effect of a sodium hyaluronate-based bioresorbable membrane (Seprafilm®; Genzyme, Cambridge, MA, USA) for reducing adhesive intestinal obstruction after colorectal cancer surgery.

Materials and methods

Between November 2002 and December 2003, 504 patients underwent radical resection for sigmoid or rectal cancer. Among these patients, 427 patients were enrolled in this study. The patients were randomized into the Seprafilm® group (N = 185) and the control group (N = 242). All the patients in the Seprafilm® group received one sheet of Seprafilm® over the pelvic inlet where the peritoneum was denuded due to pelvic dissection. Intestinal obstruction was defined when there were symptoms of nausea, vomiting, and abdominal distension combined with an obstructive bowel pattern on the radiologic evaluation.

Results

The median follow-up period was 25.0 months. There were no significant differences between the Seprafilm® and the control groups for the clinicopathologic parameters. There were no differences in the incidence of complications between the two groups; however, the incidence of early postoperative intestinal obstruction was significantly less in the Seprafilm® group than in the control group (2.7% vs 7.0%, respectively, p = 0.045). Five patients in the Seprafilm® group experienced postoperative intestinal obstruction (2.7%) compared with 11 patients in the control group (4.6%) during the follow-up period; however, there was no statistical difference.

Conclusions

Seprafilm® appears to be effective in preventing early postoperative intestinal obstruction and there was a trend for reduced intestinal obstruction after lower abdominal surgery for colorectal cancer.

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Title: Sodium hyaluronate-based bioresorbable membrane (Seprafilm®) reduced early postoperative intestinal obstruction after lower abdominal surgery for colorectal cancer: the preliminary report
Authors: Chi-Min Park
Woo Yong Lee
Yong Beom Cho
Hae Ran Yun
Won-Suk Lee
Seong Hyeon Yun
Ho-Kyung Chun
Publication date: 01-03-2009
Publisher: Springer-Verlag
Published in: International Journal of Colorectal Disease / Issue 3/2009
Print ISSN: 0179-1958
Electronic ISSN: 1432-1262
DOI: https://doi.org/10.1007/s00384-008-0602-1

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Sodium hyaluronate-based bioresorbable membrane (Seprafilm^®) reduced early postoperative intestinal obstruction after lower abdominal surgery for colorectal cancer: the preliminary report

Abstract

Purposes

Materials and methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purposes

Materials and methods

Results

Conclusions

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