Published in:
01-01-2006 | Original Article
Sclerosing therapy of internal hemorrhoids with a novel sclerosing agent
Comparison with ligation and excision
Authors:
M. Takano, J. Iwadare, H. Ohba, H. Takamura, Y. Masuda, K. Matsuo, T. Kanai, H. Ieda, Y. Hattori, S. Kurata, S. Koganezawa, K. Hamano, S. Tsuchiya
Published in:
International Journal of Colorectal Disease
|
Issue 1/2006
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Abstract
Background and aims
Patients with prolapsing internal hemorrhoids were treated with a novel sclerosing agent (OC-108), and the results were compared with surgery of ligation and excision.
Patients and methods
This study included 20 years or older patients with prolapsing internal hemorrhoids who visited ten medical institutions in Japan from October 2000 to October 2002. Investigation on surgery was also performed.
Results
Comparing OC-108 and surgery in patients with third- and fourth-degree internal hemorrhoids according to the Goligher’s classification, for which surgery has been generally indicated, at 28 days after treatment, the disappearance rate of prolapse was similar between OC-108 and surgery, 94% (75/80 patients) and 99% (84/85 patients), respectively. The 1-year recurrence rate was 16% (12/73 patients) in the OC-108 group, and this value was satisfactory because of its less invasive nature while it was more or less higher compared with 2% (2/81 patients) in the surgery group. The incidences of pain and bleeding were lower in the OC-108 group.
Conclusions
OC-108 is a useful alternative treatment for hemorrhoids.