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01-07-2019 | Liver Transplantation | Original Article

The effect of maternal grafts in early acute cellular rejection after pediatric living-donor liver transplantation

Authors: Yuki Noguchi, Takehisa Ueno, Tasuku Kodama, Ryuta Saka, Yuichi Takama, Yuko Tazuke, Kazuhiko Bessho, Hiroomi Okuyama

Published in: Pediatric Surgery International | Issue 7/2019

Abstract

Purpose

Living-donor liver transplantations (LDLTs) with maternal grafts can be more successful than those with paternal grafts because of their tolerance to non-inherited maternal antigens. We reviewed LDLT patients to investigate the relationship between acute rejection and donor sex.

Methods

LDLT patients between January 2010 and November 2015 were enrolled. ACR was defined by a rejection activity index of > 3.

Results

Forty-six patients (22 males and 24 females), of whom 28 had biliary atresia, were enrolled. The median age of the patients was 2.8 years and the donor types were maternal (n = 25) and paternal (n = 21). Acute cellular rejection (ACR) was observed in 22 patients. Twelve (48%) of the 25 patients in the maternal group had at least one episode of rejection compared with 10 (48%) of the 21 in the paternal group. Among the patients with ACR, the first rejection in the maternal group occurred significantly earlier than that in the paternal group (p < 0.01). In the multivariable analysis, the only variable significantly related to the first rejection day after LDLT was donor sex (male) (p < 0.005).

Conclusion

Our results showed that maternal grafts had an effect on causing earlier ACR in LDLT.

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Title: The effect of maternal grafts in early acute cellular rejection after pediatric living-donor liver transplantation
Authors: Yuki Noguchi
Takehisa Ueno
Tasuku Kodama
Ryuta Saka
Yuichi Takama
Yuko Tazuke
Kazuhiko Bessho
Hiroomi Okuyama
Publication date: 01-07-2019
Publisher: Springer Berlin Heidelberg
Keywords: Liver Transplantation
Liver Transplantation
Liver Transplantation
Liver Transplantation
Liver Transplantation
Published in: Pediatric Surgery International / Issue 7/2019
Print ISSN: 0179-0358
Electronic ISSN: 1437-9813
DOI: https://doi.org/10.1007/s00383-019-04487-0

Keynote webinar | Spotlight on medication adherence

Springer Medicine

The effect of maternal grafts in early acute cellular rejection after pediatric living-donor liver transplantation

Abstract

Purpose

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

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