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01-02-2018 | Original Article

The protective effect of fish oil lipid emulsions on intestinal failure-associated liver disease in a rat model of short-bowel syndrome

Authors: Seiro Machigashira, Tatsuru Kaji, Shun Onishi, Waka Yamada, Keisuke Yano, Koji Yamada, Ryuta Masuya, Takafumi Kawano, Kazuhiko Nakame, Motoi Mukai, Satoshi Ieiri

Published in: Pediatric Surgery International | Issue 2/2018

Abstract

Purpose

Pediatric patients with intestinal failure need long-term parenteral nutrition (PN), but this nutritional support causes liver dysfunction, such as intestinal failure-associated liver disease (IFALD). Several studies have shown that the lipid emulsion produced by soybean oil (SO) is associated with the occurrence of IFALD. In this study, we evaluated the effect of SO and fish oil (FO) lipid emulsion on hepatic steatosis.

Methods

Sprague-Dawley rats underwent jugular vein catheterization and were divided into three groups: sham operation with normal chow (Sham group), 80% small bowel resection (80% SBR) + TPN with SO lipid emulsion (SO group), and 80% SBR + TPN with FO lipid emulsion (FO group). All rats were euthanized and the serum biochemistry and hepatic histology analyzed.

Results

No significant differences in the serum liver or biliary enzymes were noted between the SO and FO groups. The pathological findings and NAFLD score in the FO group did not show steatosis and were significantly lower than in the SO group. An analysis of the fatty acids profile in the both the SO and FO groups did not indicate essential fatty acid deficiency (EFAD).

Conclusion

FO lipid emulsion may have a protective role against steatosis of IFALD without EFAD.

Kelly DA (2006) Intestinal failure-associated liver disease: what do we know today? Gastroenterology 130(2 Suppl 1):S70–77. doi:10.1053/j.gastro.2005.10.066

Kelly DA (1998) Liver complications of pediatric parenteral nutrition—epidemiology. Nutrition 14(1):153–157CrossRefPubMed

Wilmore DW, Groff DB, Bishop HC, Dudrick SJ (1969) Total parenteral nutrition in infants with catastrophic gastrointestinal anomalies. J Pediatr Surg 4(2):181–189CrossRefPubMed

Nandivada P, Cowan E, Carlson SJ, Chang M, Gura KM, Puder M (2013) Mechanisms for the effects of fish oil lipid emulsions in the management of parenteral nutrition-associated liver disease. Prostaglandin Leukot Essent Fat Acids 89(4):153–158. doi:10.1016/j.plefa.2013.02.008 CrossRef

de Meijer VE, Gura KM, Meisel JA, Le HD, Puder M (2010) Parenteral fish oil monotherapy in the management of patients with parenteral nutrition-associated liver disease. Arch Surg 145(6):547–551. doi:10.1001/archsurg.2010.80 CrossRefPubMed

Wales PW, Allen N, Worthington P, George D, Compher C, American Society for P, Enteral N, Teitelbaum D (2014) A.S.P.E.N. clinical guidelines: support of pediatric patients with intestinal failure at risk of parenteral nutrition-associated liver disease. JPEN J Parenter Enter Nutr 38(5):538–557. doi:10.1177/0148607114527772 CrossRef

Nawata A, Noguchi H, Mazaki Y, Kurahashi T, Izumi H, Wang KY, Guo X, Uramoto H, Kohno K, Taniguchi H, Tanaka Y, Fujii J, Sasaguri Y, Tanimoto A, Nakayama T, Yamada S (2016) Overexpression of peroxiredoxin 4 affects intestinal function in a dietary mouse model of nonalcoholic fatty liver disease. PloS One 11(4):e0152549. doi:10.1371/journal.pone.0152549 CrossRefPubMedPubMedCentral

Holman RT, Smythe L, Johnson S (1979) Effect of sex and age on fatty acid composition of human serum lipids. Am J Clin Nutr 32(12):2390–2399CrossRefPubMed

Koletzko B, Goulet O, Hunt J, Krohn K, Shamir R, Parenteral Nutrition Guidelines Working G, European Society for Clinical N, Metabolism, European Society of Paediatric Gastroenterology Nutrition H, European Society of Paediatric R (2005) Guidelines on paediatric parenteral nutrition of the European Society of Paediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN) and the European Society for Clinical Nutrition and Metabolism (ESPEN), supported by the European Society of Paediatric Research (ESPR). J Pediatr Gastroenterol Nutr 41(Suppl 2):S1–87CrossRefPubMed

10.

Chen WJ, Yeh SL, Huang PC (1996) Effects of fat emulsions with different fatty acid composition on plasma and hepatic lipids in rats receiving total parenteral nutrition. Clin Nutr 15(1):24–28CrossRefPubMed

11.

Park Y, Harris WS (2003) Omega-3 fatty acid supplementation accelerates chylomicron triglyceride clearance. J Lipid Res 44(3):455–463. doi:10.1194/jlr.M200282-JLR200 CrossRefPubMed

12.

Gura KM, Parsons SK, Bechard LJ, Henderson T, Dorsey M, Phipatanakul W, Duggan C, Puder M, Lenders C (2005) Use of a fish oil-based lipid emulsion to treat essential fatty acid deficiency in a soy allergic patient receiving parenteral nutrition. Clin Nutr 24(5):839–847. doi:10.1016/j.clnu.2005.05.020 CrossRefPubMed

13.

Das UN (2006) Essential fatty acids: biochemistry, physiology and pathology. Biotechnol J 1(4):420–439. doi:10.1002/biot.200600012 CrossRefPubMed

14.

Meisel JA, Le HD, de Meijer VE, Nose V, Gura KM, Mulkern RV, Akhavan Sharif MR, Puder M (2011) Comparison of 5 intravenous lipid emulsions and their effects on hepatic steatosis in a murine model. J Pediatr Surg 46(4):666–673. doi:10.1016/j.jpedsurg.2010.08.018 CrossRefPubMed

15.

Venick RS, Calkins K (2011) The impact of intravenous fish oil emulsions on pediatric intestinal failure-associated liver disease. Curr Opin Org Transpl 16(3):306–311. doi:10.1097/MOT.0b013e32834670eb CrossRef

16.

Calkins KL, Dunn JC, Shew SB, Reyen L, Farmer DG, Devaskar SU, Venick RS (2014) Pediatric intestinal failure-associated liver disease is reversed with 6 months of intravenous fish oil. JPEN J Parenter Enter Nutr 38(6):682–692. doi:10.1177/0148607113495416 CrossRef

17.

Puder M, Valim C, Meisel JA, Le HD, de Meijer VE, Robinson EM, Zhou J, Duggan C, Gura KM (2009) Parenteral fish oil improves outcomes in patients with parenteral nutrition-associated liver injury. Ann Surg 250(3):395–402. doi:10.1097/SLA.0b013e3181b36657 PubMedPubMedCentral

18.

Bays HE (2007) Safety considerations with omega-3 fatty acid therapy. Am J Cardiol 99(6A):35C–43C. doi:10.1016/j.amjcard.2006.11.020 CrossRefPubMed

19.

Davis-Bruno K, Tassinari MS (2011) Essential fatty acid supplementation of DHA and ARA and effects on neurodevelopment across animal species: a review of the literature. Birth Defect Res Part B Dev Reprod Toxicol 92(3):240–250. doi:10.1002/bdrb.20311 CrossRef

Title: The protective effect of fish oil lipid emulsions on intestinal failure-associated liver disease in a rat model of short-bowel syndrome
Authors: Seiro Machigashira
Tatsuru Kaji
Shun Onishi
Waka Yamada
Keisuke Yano
Koji Yamada
Ryuta Masuya
Takafumi Kawano
Kazuhiko Nakame
Motoi Mukai
Satoshi Ieiri
Publication date: 01-02-2018
Publisher: Springer Berlin Heidelberg
Published in: Pediatric Surgery International / Issue 2/2018
Print ISSN: 0179-0358
Electronic ISSN: 1437-9813
DOI: https://doi.org/10.1007/s00383-017-4190-4

Keynote webinar | Spotlight on medication adherence

Springer Medicine

The protective effect of fish oil lipid emulsions on intestinal failure-associated liver disease in a rat model of short-bowel syndrome

Abstract

Purpose

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

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