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01-12-2017 | Review Article

Liver transplantation for biliary atresia: a systematic review

Authors: Mureo Kasahara, Koji Umeshita, Seisuke Sakamoto, Akinari Fukuda, Hiroyuki Furukawa, Shinji Uemoto

Published in: Pediatric Surgery International | Issue 12/2017

Abstract

Biliary atresia (BA) is an idiopathic neonatal cholangiopathy characterized by progressive inflammatory obliteration of the intrahepatic or extrahepatic bile ducts. Although the Kasai operation has dramatically improved the outcomes in children with BA, most patients with BA eventually require liver transplantation (LT) even after undergoing a successful Kasai procedure. The Japanese LT Society (JLTS) was established in 1980 to characterize and follow trends in patient characteristics and the graft survival among all liver transplant patients in Japan. The 1-, 5-, 10-, 15- and 20-year survival rates for the patients and grafts undergoing living donor LT were 91.6, 91.5, 87.1, 85.4 and 84.2 and 90.5, 90.4, 84.6, 82.0 and 79.9%, respectively. LDLT was able to be performed even in patients weighing less than 5 kg with early liver failure following a Kasai operation using a reduced left lateral segments. As LT has been revealed to increase the donor pool and decrease the waiting list mortality with an excellent long-term graft survival, early referral to a transplant center should be considered when at least one complication of cirrhosis occurs during its natural history, especially in adolescents.

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Title: Liver transplantation for biliary atresia: a systematic review
Authors: Mureo Kasahara
Koji Umeshita
Seisuke Sakamoto
Akinari Fukuda
Hiroyuki Furukawa
Shinji Uemoto
Publication date: 01-12-2017
Publisher: Springer Berlin Heidelberg
Published in: Pediatric Surgery International / Issue 12/2017
Print ISSN: 0179-0358
Electronic ISSN: 1437-9813
DOI: https://doi.org/10.1007/s00383-017-4173-5

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Liver transplantation for biliary atresia: a systematic review

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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