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Pediatric Surgery International

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01-03-2015 | Original Article

Do infants with gastroschisis may have a high incidence of non-IgE-mediated cow’s milk protein allergy?

Authors: David Burge, Melanie Drewett, Nigel Hall

Published in: Pediatric Surgery International | Issue 3/2015

Abstract

Background/purpose

To determine the frequency and characteristics of suspected cow’s milk protein allergy (CMPA) in infants with gastroschisis and response to change in milk.

Methods

A retrospective cohort study of 111 consecutive infants with gastroschisis.

Results

64 episodes suggesting non-IgE-mediated CMPA occurred in 50 infants (45 %) at a median age of 44 days (9–186) and during the primary admission in 38 %. At the time of the episode the infant feed was breast milk (BM, n = 24), term formula (TF, n = 20) or extensively hydrolysed formula (EHF, n = 6). The feed was changed to EHF (34), amino acid formula (AAF) (14) or BM with maternal CMP-free diet (2). Partial or complete resolution of symptoms occurred in all. There was histological evidence of an allergic reaction to CMP in all four infants in whom tissue was available. Recurrent episodes occurred in 13/50 infants (26 %), 10 of whom were receiving EHF. There were no recurrent episodes in infants being fed with AAF.

Conclusion

Features suggesting non-IgE-mediated CMPA appear common in infants with gastroschisis.

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Title: Do infants with gastroschisis may have a high incidence of non-IgE-mediated cow’s milk protein allergy?
Authors: David Burge
Melanie Drewett
Nigel Hall
Publication date: 01-03-2015
Publisher: Springer Berlin Heidelberg
Published in: Pediatric Surgery International / Issue 3/2015
Print ISSN: 0179-0358
Electronic ISSN: 1437-9813
DOI: https://doi.org/10.1007/s00383-015-3664-5

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Do infants with gastroschisis may have a high incidence of non-IgE-mediated cow’s milk protein allergy?

Abstract

Background/purpose

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background/purpose

Methods

Results

Conclusion

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