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Pediatric Surgery International

Published in:

01-03-2012 | Original Article

Pediatric risk of malignancy index for preoperative evaluation of childhood ovarian tumors

Authors: Amos Hong Pheng Loh, Chiou Li Ong, Shu Lin Lam, Joyce Horng Yiing Chua, Chan Hon Chui

Published in: Pediatric Surgery International | Issue 3/2012

Abstract

Purpose

This study aimed to develop and provisionally validate a novel scoring index for preoperative cancer-risk prediction in childhood ovarian tumors.

Methods

Fifty-five girls aged 18 and below underwent surgery for ovarian masses between 2004 and 2009. Benign or non-benign histological diagnoses (the latter including all malignant and borderline tumors and tumors containing immature components) were correlated with clinical and biochemical parameters, and blinded scores of ultrasound and computed-tomography using multivariate logistic regression. Regression coefficients were used as weighting factors to create an additive index. This index was validated prospectively against 23 consecutive adnexal masses operated in 2010.

Results

In total, 67 tumors were benign and 11 non-benign. Non-benign diagnosis was independently associated with the maximum diameter of the largest solid component (score = value in cm), the presence of sex hormone-related symptoms (score = +6), and enhancement or flow in a septum or solid papillary projection (score = +4). The novel scoring index was calculated as the total score of these three parameters. A cutoff score of 7 gave a specificity of 97.9% and sensitivity of 87.5% for the training data set, and specificity and sensitivity of 100% for the pilot testing set.

Conclusion

The novel pediatric risk-of-malignancy index is able to accurately discriminate between benign and non-benign ovarian tumors in children and adolescents. Its preoperative application may guide surgical management decisions before the availability of histological confirmation.

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Title: Pediatric risk of malignancy index for preoperative evaluation of childhood ovarian tumors
Authors: Amos Hong Pheng Loh
Chiou Li Ong
Shu Lin Lam
Joyce Horng Yiing Chua
Chan Hon Chui
Publication date: 01-03-2012
Publisher: Springer-Verlag
Published in: Pediatric Surgery International / Issue 3/2012
Print ISSN: 0179-0358
Electronic ISSN: 1437-9813
DOI: https://doi.org/10.1007/s00383-011-3031-0

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Pediatric risk of malignancy index for preoperative evaluation of childhood ovarian tumors

Abstract

Purpose

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

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