Published in:
01-12-2009 | Original Article
Role of alpha adrenergic blocker in the management of posterior urethral valves
Published in: Pediatric Surgery International | Issue 12/2009
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Purpose
To evaluate the effect of Terazosin (α1 adrenergic blocker) on bladder emptying in children with posterior urethral valves.
Materials and methods
Forty-two children with significant post void residual urine after valves ablation were placed on Terazosin ranging from 0.25 to 2 mg. Post void urine at the commencement and at follow up was monitored with abdominal ultrasound.
Results
Post void residual urine significantly reduced in 40 patients (95%) who were put on Terazosin. Mean pretreatment PVR was 15.7 ml and mean PVR at the last follow up was 2.4 ml (P = 0.000). This was a reduction of 85% in the pretreatment post void residual urine volume. All the patients had improvement in urinary stream. One patient reacted to Terazosin with hypotension necessitating its withdrawal. Mean follow up was 17 months.
Conclusion
Terazosin has proved to be safe and results in significant improvement in bladder emptying in our patients with posterior urethral valves. Randomized controlled trial and long-term follow up are necessary to further define the role of α1 adrenergic blocker therapy in children with posterior urethral valves. This study will become the justification for such a study.