Top

Published in:

01-11-2009 | Original Article

Outcome of pediatric renal tumor treated using the Japan Wilms Tumor Study-1 (JWiTS-1) protocol: a report from the JWiTS Group

Authors: Takaharu Oue, Masahiro Fukuzawa, Hajime Okita, Hideo Mugishima, Hiroshi Horie, Jun-ichi Hata, Masahiro Saito, Miwako Nozaki, Motoaki Chin, Hisaya Nakadate, Shiro Hinotsu, Tsugumichi Koshinaga, Yasuhiko Kaneko, Yoshihiro Kitano, Yukichi Tanaka, Japan Wilms Tumor Study (JWiTS) Group

Published in: Pediatric Surgery International | Issue 11/2009

Abstract

Purpose

In 1996, the Japan Wilms Tumor Study (JWiTS) group was founded to elucidate the efficacy and safety of the regimen established by the National Wilms Tumor Study (NWTS) group in the USA, and a multicenter cooperative study (JWiTS-1) was started in Japan. This report reviews the results of JWiTS-1.

Methods

A total of 307 patients with malignant renal tumor were enrolled in the JWiTS-1 study between 1996 and 2005. Central pathological diagnosis and follow-up data were available in 210 cases. The protocol regimens were similar to the NWTS-5 regimens. Clinical stage was classified according to the Japanese Staging System.

Results

Five-year overall survival (OS) rate was 91.1% for nephroblastoma, 72.9% for clear cell sarcoma of the kidney (CCSK), and 22.2% for rhabdoid tumor of the kidney (RTK). In the nephroblastoma patients, 5-year OS was 90.5% for stage I disease, 92.2% for stage II, 90.9% for stage III, 86.7% for stage IV, and 78.7% for stage V.

Conclusions

The OS of patients in the JWiTS-1 study were comparable with the results of other multicenter studies in the USA and Europe. The outcome for patients with nephroblastoma and CCSK was fair. In contrast, the cure rate for those with RTK was not satisfactory. New treatment strategies are needed for patients with RTK.

D’Angio GJ (2007) The National Wilms’ Tumor Study: a 40 year perspective. Lifetime Data Anal 13:463–470CrossRefPubMed

D’Angio GJ, Evans AE, Breslow N et al (1976) The treatment of Wilms’ tumor: results of the national Wilms’ tumor study. Cancer 38:633–646CrossRefPubMed

Grundy P, Perlman E, Rosen NS et al (2005) Current issues in Wilms tumor management. Curr Probl Cancer 29:221–260CrossRefPubMed

Shamberger RC, Guthrie KA, Ritchey ML et al (1999) Surgery-related factors and local recurrence of Wilms’ tumor in National Wilms’ Tumor Study 4. Ann Surg 229:292–297CrossRefPubMed

Mitchell C, Jones KP, Shannon R et al (2006) Immediate nephrectomy versus preoperative chemotherapy in the management of non-metastatic Wilms’ tumour: results of a randomised trial (UKW3) by the UK children’s cancer study group. Eur J Cancer 42:2554–2562CrossRefPubMed

Weirich A, Leuschner I, Harms D et al (2001) Clinical impact of histologic subtypes in localized non-anaplastic nephroblastoma treated according to the trial and study SIOP-9/GPOH. Ann Oncol 12:311–319CrossRefPubMed

de Kraker J, Graf N, van Tinteren H et al (2004) Reduction of postoperative chemotherapy in children with stage I intermediate-risk and anaplastic Wilms’ tumour (SIOP 93–01 trial): a randomised controlled trial. Lancet 364:1229–1235CrossRefPubMed

Malignant Tumor Committee of the Japanese Society of Pediatric Surgeons (2003) The follow up data of the Pediatric solid malignancies registered from 1991 to 1995. J Jpn Soc Pediatr Surg 39:677–706

Pizzo PA et al (eds) (2001) Principles and practice of pediatric oncology, 5th edn. Chapter 30 renal tumors. Lippincott Williams & Wilkins, Philadelphia, pp 905–932

10.

Jereb B, Burgers JM, Tournade MF et al (1994) Radiotherapy in the SIOP (International Society of Pediatric Oncology) Nephroblastoma studies: a review. Med Pediatr Oncol 22:221–227CrossRefPubMed

11.

Beckwith JB, Palmer NF (1978) Histopathology and prognosis of Wilms’ tumours: results from the first national Wilms’ tumour study. Cancer 41:1937–1948CrossRefPubMed

12.

Green DM, Breslow NE, Beckwith JB et al (1994) Treatment of children with clear-cell sarcoma of the kidney: a report from the National Wilms’ Tumor Study Group. J Clin Oncol 12:2132–2137PubMed

13.

Haas JE, Palmer NF, Weinberg AG et al (1981) Ultrastructure of malignant rhabdoid tumor of the kidney: a distinctive renal tumor of children. Hum Pathol 12:646–657CrossRefPubMed

14.

Haas JE, Bonadio JF, Beckwith JB (1984) Clear cell sarcoma of the kidney with emphasis on ultrastructural studies. Cancer 54:2978–2987CrossRefPubMed

15.

Weeks DA, Beckwith JB, Mierau GW et al (1989) Rhabdoid tumor of kidney: a report of 111 cases from the National Wilms’ Tumor Study Pathology Center. Am J Surg Pathol 13:439–458PubMedCrossRef

16.

Green DM, Breslow NE, Beckwith JB et al (2001) Treatment with nephrectomy only for small, stage I/favourable histology Wilms’ tumour: a report from the national Wilms’ tumour study group. J Clin Oncol 19:3719–3724PubMed

17.

Montgomery BT, Kelalis PP, Blute ML et al (1991) Extended follow-up of bilateral Wilms’ tumor: results of the National Wilms’ tumor study. J Urol 146:514–518PubMed

18.

Bishop HC, Tefft M, Evans AE et al (1977) Survival in bilateral Wilms’ tumor–review of 30 National Wilms’ Tumor Study cases. J Pediatr Surg 12:631–638CrossRefPubMed

19.

Blute ML, Kelalis PP, Offord KP et al (1987) Bilateral Wilms’ tumor. J Urol 138:968–973PubMed

20.

Grundy PE, Breslow N, Li S et al (2005) Loss of Heterozygosity for Chromosomes 1p and 16q is an adverse prognostic factor in favorable histology Wilms’ tumor: a report from the National Wilms’ Tumor Study Group. J Clin Oncol 23:7312–7321CrossRefPubMed

21.

Dome JS, Bockhold CA, Li SM et al (2005) High telomerase RNA expression level is an adverse prognostic factor for favorable-histology Wilms’ tumour. J Clin Oncol 23:9138–9145CrossRefPubMed

22.

Watanabe N, Nakadate H, Haruta M et al (2006) Association of 11q loss, trisomy 12 and possible 16q loss with loss of imprinting of insulin-like growth factor-II in Wilms tumor. Genes Chromosomes Cancer 45:592–601CrossRefPubMed

23.

Haruta M, Arai Y, Sugawara W et al (2008) Duplication of paternal IGF2 or loss of maternal IGF2 imprinting occurs in half of Wilms tumors with various structural WT1 abnormalities. Genes Chromosomes Cancer 47:712–727CrossRefPubMed

24.

Haruta M, Matsumoto Y, Izumi H et al (2008) Combined BubR1 protein down-regulation and RASSF1A hypermethylation in Wilms tumors with diverse cytogenetic changes. Mol Carcinog 47:660–666CrossRefPubMed

Title: Outcome of pediatric renal tumor treated using the Japan Wilms Tumor Study-1 (JWiTS-1) protocol: a report from the JWiTS Group
Authors: Takaharu Oue
Masahiro Fukuzawa
Hajime Okita
Hideo Mugishima
Hiroshi Horie
Jun-ichi Hata
Masahiro Saito
Miwako Nozaki
Motoaki Chin
Hisaya Nakadate
Shiro Hinotsu
Tsugumichi Koshinaga
Yasuhiko Kaneko
Yoshihiro Kitano
Yukichi Tanaka
Japan Wilms Tumor Study (JWiTS) Group
Publication date: 01-11-2009
Publisher: Springer-Verlag
Published in: Pediatric Surgery International / Issue 11/2009
Print ISSN: 0179-0358
Electronic ISSN: 1437-9813
DOI: https://doi.org/10.1007/s00383-009-2449-0

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Outcome of pediatric renal tumor treated using the Japan Wilms Tumor Study-1 (JWiTS-1) protocol: a report from the JWiTS Group

Abstract

Purpose

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

Please log in to get access to this content

Other articles of this Issue 11/2009

Immature enteric neurons in Ncx/Hox11L.1 deficient intestinal neuronal dysplasia model mice

Hyperplastic polyp of the gallbladder associated with pancreaticobiliary maljunction in a 9-year-old girl

Collis–Nissen fundoplication using a computer-powered right angle linear cutting stapler in children

Hirschsprung’s disease patients diagnosed at over 15 years of age: an analysis of a Japanese nationwide survey

Sonic hedgehog gene expression in nitrofen induced hypoplastic lungs in mice

Repeat STEP procedure to establish enteral nutrition in an infant with short bowel syndrome