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Pediatric Surgery International

Published in:

01-03-2009 | Original Article

Different polyunsaturated fatty acid profiles in patients with biliary atresia after successful Kasai operation and liver transplantation

Authors: Wataru Sumida, Kenitiro Kaneko, Yasuyuki Ono, Takahisa Tainaka, Hisami Ando

Published in: Pediatric Surgery International | Issue 3/2009

Abstract

Background

Although Kasai operation eliminates jaundice in patients with biliary atresia, inflammation at Glisson’s area persists and fibrosis advances slowly to liver cirrhosis. Profiles of polyunsaturated fatty acids, on which metabolic products have an immunoregulative effect, were investigated in this study.

Methods

Blood samples were obtained from patients including 21 jaundice-free patients with biliary atresia after Kasai operation (native liver group) and 18 patients in whom Kasai operation failed and liver transplantation was performed (transplantation group). All of these patients are without any complications for more than 6 months. Blood samples from 18 patients with inguinal hernia were assigned as normal controls (control group). Profiles of fatty acids in whole serum lipids were measured using gas chromatography. The n-3/n-6 ratio of polyunsaturated fatty acids was compared among the three groups.

Results

The n-3/n-6 ratio was 0.114 in the native liver group, which was significantly lower than 0.145 in the transplantation group (P = 0.009) and 0.158 in the control group (P = 0.004). There was no significant difference between the transplantation and control groups (P = 0.83).

Results

The n-3/n-6 ratio was abnormal after Kasai operation despite normal liver function. This seems to be one factor of persisting inflammation in Glisson’s area.

Sokol RJ, Mack C, Narkewicz MR et al (2003) Pathogenesis and outcome of biliary atresia: current concepts. J Pediatr Gastroenterol Nutr 37:4–21. doi:10.1097/00005176-200307000-00003 PubMedCrossRef

Kasai M (1974) Treatment of biliary atresia with special reference to hepatic porto-enterostomy and its modifications. Prog Pediatr Surg 6:5–52PubMed

Nio M, Ohi R, Miyano T et al (2003) Five- and 10-year survival rates after surgery for biliary atresia: a report from the Japanese Biliary Atresia Registry. J Pediatr Surg 38:997–1000. doi:10.1016/S0022-3468(03)00178-7 PubMedCrossRef

Stocker JT, Husain AN, Dehner LP (2001) The liver, gallbladder, and biliary tract. In: Stocker JT, Dehner LP et al (eds) Pediatric pathology, 2nd edn, Chap. 16. Lippincott Williams & Wilkins, Philadelphia, pp 709–712

Asakawa T, Tanaka Y, Asagiri K, Kobayashi H, Tanikawa K, Yagi M (2009) Oxidative stress profile in the post-operative patients with biliary atresia. Pediatr Surg Int 25(1):93–97PubMedCrossRef

De Carvalho E, Ivantes CAP, Bezerra JA (2007) Extrahepatic biliary atresia: current concepts and future directions. J Pediatr 83:105–120. doi:10.2223/JPED.1608 CrossRef

Kelly DA, Davenport M (2007) Current management of biliary atresia. Arch Dis Child 92:1132–1135. doi:10.1136/adc.2006.101451 PubMedCrossRef

Das UN (2006) Essential fatty acids: biochemistry, physiology and pathology. Biotechnol J 1:420–439. doi:10.1002/biot.200600012 PubMedCrossRef

Hudert CA, Weylandt KH, Lu Y et al (2006) Transgenic mice rich in endogenious omega-3 fatty acid are protected from colitis. Proc Natl Acad Sci USA 103:11276–11281. doi:10.1073/pnas.0601280103 PubMedCrossRef

10.

Lee S, Kim S, Le HD et al (2008) Reduction of hepatocellular injury after common bile duct ligation using omega-3 fatty acids. J Pediatr Surg 43:2010–2015. doi:10.1016/j.jpedsurg.2008.05.030 PubMedCrossRef

11.

Lee TH, Hoover RL, Williams JD et al (1985) Effect of dietary enrichment with eicosapentaenoic and docosahexaenoic acids on in vitro neutrophil and monocyte leukotriene generation and neutrophil function. N Engl J Med 312:1217–1224PubMed

12.

Belluzzi A, Boschi S, Brignola C et al (2000) Polyunsaturated fatty acid and inflammatory bowel disease. Am J Clin Nutr 71(suppl):339S–342SPubMed

13.

Freedman SD, Blanco PG, Zaman MM et al (2004) Association of cystic fibrosis with abnormalities in fatty acid metabolism. N Engl J Med 350:560–569. doi:10.1056/NEJMoa021218 PubMedCrossRef

14.

Mayser P, Mayer K, Mahloudjian M et al (2002) A double-blind, randomized, placebo-controlled trial of n-3 versus n-6 fatty acid-based lipid infusion in atopic dermatitis. J Parenter Enter Nutr 26:151–158. doi:10.1177/0148607102026003151 CrossRef

15.

Yamashiro Y, Shimizu T, Ohtsuka Y et al (1994) Docosahexaenoic acid status of patients with extrahepatic biliary atresia. J Pediatr Surg 29:1455–1458. doi:10.1016/0022-3468(94)90143-0 PubMedCrossRef

16.

Takamatsu H, Noguchi H, Tahara H et al (1999) Plasma fatty acids concentrations in postoperative patients with biliary atresia. Nutrition 15:755–759. doi:10.1016/S0899-9007(99)00150-1 PubMedCrossRef

17.

Alexandre L, Christine H, Valerie M et al (2000) Effects of liver transplantation on long-chain polyunsaturated fatty acid status in infants with biliary atresia. J Pediatr Gastroenterol Nutr 30:528–532. doi:10.1097/00005176-200005000-00012 CrossRef

18.

Miyano T, Yamashiro Y, Shimizu T et al (1986) Essential fatty acid deficiency in congenital biliary atresia: successful treatment to reverse deficiency. J Pediatr Surg 21:277–281. doi:10.1016/S0022-3468(86)80854-5 PubMedCrossRef

19.

Yamashiro Y, Ohtsuka Y, Shimizu T et al (1994) Effect of ursodeoxycholic acid treatment on essential fatty acid deficiency in patients with biliary atresia. J Pediatr Surg 29:425–428. doi:10.1016/0022-3468(94)90584-3 PubMedCrossRef

Title: Different polyunsaturated fatty acid profiles in patients with biliary atresia after successful Kasai operation and liver transplantation
Authors: Wataru Sumida
Kenitiro Kaneko
Yasuyuki Ono
Takahisa Tainaka
Hisami Ando
Publication date: 01-03-2009
Publisher: Springer-Verlag
Published in: Pediatric Surgery International / Issue 3/2009
Print ISSN: 0179-0358
Electronic ISSN: 1437-9813
DOI: https://doi.org/10.1007/s00383-009-2324-z

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Different polyunsaturated fatty acid profiles in patients with biliary atresia after successful Kasai operation and liver transplantation

Abstract

Background

Methods

Results

Results

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Results

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