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Open Access 01-07-2008 | Review Article

Congenital diaphragmatic hernia and retinoids: searching for an etiology

Authors: Sandra Montedonico, Nana Nakazawa, Prem Puri

Published in: Pediatric Surgery International | Issue 7/2008

Abstract

Congenital diaphragmatic hernia (CDH) is a major life-threatening cause of respiratory failure in the newborn. Recent data reveal the role of a retinoid-signaling pathway disruption in the pathogenesis of CDH. We describe the epidemiology and pathophysiology of human CDH, the metabolism of retinoids and the implications of retinoids in the development of the diaphragm and lung. Finally, we describe the existing evidence of a disruption of the retinoid-signaling pathway in CDH.

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Title: Congenital diaphragmatic hernia and retinoids: searching for an etiology
Authors: Sandra Montedonico
Nana Nakazawa
Prem Puri
Publication date: 01-07-2008
Publisher: Springer-Verlag
Published in: Pediatric Surgery International / Issue 7/2008
Print ISSN: 0179-0358
Electronic ISSN: 1437-9813
DOI: https://doi.org/10.1007/s00383-008-2140-x

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Congenital diaphragmatic hernia and retinoids: searching for an etiology

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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