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Child's Nervous System
Published in: Child's Nervous System 11/2016

01-11-2016 | Review Paper

Pathogenesis of cerebral palsy through the prism of immune regulation of nervous tissue homeostasis: literature review

Authors: Natalya Lisovska, Zholtay Daribayev, Yevgeny Lisovskyy, Kenzhe Kussainova, Lana Austin, Sholpan Bulekbayeva

Published in: Child's Nervous System | Issue 11/2016

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Abstract

Background

The cerebral palsy is highly actual issue of pediatrics, causing significant neurological disability. Though the great progress in the neuroscience has been recently achieved, the pathogenesis of cerebral palsy is still poorly understood.

Methods

In this work, we reviewed available experimental and clinical data concerning the role of immune cells in pathogenesis of cerebral palsy. Maintaining of homeostasis in nervous tissue and its transformation in case of periventricular leukomalacia were analyzed.

Results

The reviewed data demonstrate involvement of immune regulatory cells in the formation of nervous tissue imbalance and chronicity of inborn brain damage. The supported opinion, that periventricular leukomalacia is not a static phenomenon, but developing process, encourages our optimism about the possibility of its correction.

Conclusions

The further studies of changes of the nervous and immune systems in cerebral palsy are needed to create fundamentally new directions of the specific therapy and individual schemes of rehabilitation.
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Metadata
Title
Pathogenesis of cerebral palsy through the prism of immune regulation of nervous tissue homeostasis: literature review
Authors
Natalya Lisovska
Zholtay Daribayev
Yevgeny Lisovskyy
Kenzhe Kussainova
Lana Austin
Sholpan Bulekbayeva
Publication date
01-11-2016
Publisher
Springer Berlin Heidelberg
Published in
Child's Nervous System / Issue 11/2016
Print ISSN: 0256-7040
Electronic ISSN: 1433-0350
DOI
https://doi.org/10.1007/s00381-016-3245-5

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