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Child's Nervous System
Published in: Child's Nervous System 8/2015

01-08-2015 | Case Report

Atypical teratoid rhabdoid tumor: long-term survival after chemoradiotherapy

Authors: Vivek Verma, Catrina P. Johnson, Nathan R. Bennion, Abhijeet R. Bhirud, Sicong Li, Rodney D. McComb, Chi Lin

Published in: Child's Nervous System | Issue 8/2015

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Abstract

Purpose

Atypical teratoid rhabdoid tumors (ATRTs) arise from the central nervous system largely in the pediatric population. They portend a very poor prognosis with few long-term survivors. We describe a series of five cases at our institution.

Methods

We conducted a retrospective chart review and clinical follow-up.

Results

Three patients underwent chemoradiation after surgical resection; the two patients whose caretakers declined this therapy passed away soon after diagnosis. Chemoradiation included intravenous and intrathecal chemotherapy as well as intensity-modulated radiotherapy after resection. Of the patients receiving chemoradiation, two patients had infratentorial tumors, two had gross residual tumor after resection, and two were under the age of 3 years. The three patients receiving trimodality therapy remain clinically and symptomatically disease-free with follow-up times of 44, 46, and 55 months. Two of the patients have mild neuropsychiatric sequelae after therapy.

Conclusions

Long-term, high-volume trials of ATRT are currently not published. We offer experience in successful long-term survival of this tumor treated with chemoradiotherapy.
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Metadata
Title
Atypical teratoid rhabdoid tumor: long-term survival after chemoradiotherapy
Authors
Vivek Verma
Catrina P. Johnson
Nathan R. Bennion
Abhijeet R. Bhirud
Sicong Li
Rodney D. McComb
Chi Lin
Publication date
01-08-2015
Publisher
Springer Berlin Heidelberg
Published in
Child's Nervous System / Issue 8/2015
Print ISSN: 0256-7040
Electronic ISSN: 1433-0350
DOI
https://doi.org/10.1007/s00381-015-2723-5

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