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01-06-2011 | Case Report

High-dose chemotherapy followed by autologous and allogeneic peripheral blood stem cell transplantation for recurrent disseminated trilateral retinoblastoma

Authors: Toshihisa Tsuruta, Yasuo Aihara, Hitoshi Kanno, Chikako Kiyotani, Katsuya Maebayashi, Masako Sakauchi, Makiko Osawa, Hisaichi Fujii, Osami Kubo, Yoshikazu Okada

Published in: Child's Nervous System | Issue 6/2011

Abstract

Introduction

Trilateral retinoblastoma (TRb) is an intracranial neurogenic tumor associated with unilateral or bilateral retinoblastoma and has very poor prognosis. Patients typically die from leptomeningeal tumor dissemination.

Case report

A 3-year-old girl who had been diagnosed with TRb had a disseminated relapse after a tumorectomy, cerebrospinal irradiation, and conventional chemotherapy. The disseminated tumor disappeared after the first autologous peripheral blood stem cell transplantation (PBSCT) with high-dose melphalan and thiotepa. During the second complete remission, a second autologous PBSCT with high-dose busulfan and melphalan was performed. Seven months after the first PBSCT, the second relapse occurred, and we subsequently performed an allogeneic PBSCT with myeloablative chemotherapy consisting of melphalan, thiotepa, and cyclophosphamide. The patient showed clinical improvement after the allogeneic PBSCT.

Conclusion

Although high-dose chemotherapies have a curative effect for some patients with TRb, the prognoses of disseminated tumors are still poor. Further examination of the high-dose chemotherapy is necessary for the time, the conditioning drugs, and the hematopoietic stem cell sources.

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Title: High-dose chemotherapy followed by autologous and allogeneic peripheral blood stem cell transplantation for recurrent disseminated trilateral retinoblastoma
Authors: Toshihisa Tsuruta
Yasuo Aihara
Hitoshi Kanno
Chikako Kiyotani
Katsuya Maebayashi
Masako Sakauchi
Makiko Osawa
Hisaichi Fujii
Osami Kubo
Yoshikazu Okada
Publication date: 01-06-2011
Publisher: Springer-Verlag
Published in: Child's Nervous System / Issue 6/2011
Print ISSN: 0256-7040
Electronic ISSN: 1433-0350
DOI: https://doi.org/10.1007/s00381-011-1419-8

Keynote webinar | Spotlight on medication adherence

Springer Medicine

High-dose chemotherapy followed by autologous and allogeneic peripheral blood stem cell transplantation for recurrent disseminated trilateral retinoblastoma

Abstract

Introduction

Case report

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Introduction

Case report

Conclusion

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