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Child's Nervous System
Published in: Child's Nervous System 10/2009

01-10-2009 | Invited Paper

Neuropsychological sequelae and quality of life following treatment of posterior fossa ependymomas in children

Authors: Constantinos Charalambides, Argyris Dinopoulos, Spyros Sgouros

Published in: Child's Nervous System | Issue 10/2009

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Abstract

Introduction

Modern treatment of posterior fossa ependymomas in children has improved the overall survival, but as more children live longer, the neuropsychological problems that they endure as result of the disease and its treatment become more the focus of attention.

Material

Early problems such as cerebellar mutism appear to be related to surgery and do not seem to be influenced in their incidence or outcome by the otherwise beneficial effect of oncological treatment. Indeed, the cause of cerebellar mutism is still elusive. While it was originally believed to be totally reversible, it is increasingly realized that it may be related to more complex delayed neuropsychological problems. Late problems such as the cerebellar cognitive affective syndrome are increasingly being recognized. The deleterious effect of both surgery and radiotherapy that is commonly administered afterwards is now well appreciated.

Conclusion

Careful neuropsychological assessment of these children and early intervention will maximize chances for recovery and improvement of academic functions and quality of life issues.
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Metadata
Title
Neuropsychological sequelae and quality of life following treatment of posterior fossa ependymomas in children
Authors
Constantinos Charalambides
Argyris Dinopoulos
Spyros Sgouros
Publication date
01-10-2009
Publisher
Springer-Verlag
Published in
Child's Nervous System / Issue 10/2009
Print ISSN: 0256-7040
Electronic ISSN: 1433-0350
DOI
https://doi.org/10.1007/s00381-009-0927-2

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