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Child's Nervous System
Published in: Child's Nervous System 1/2009

01-01-2009 | Original Paper

Atypical basal ganglia germinoma presenting as cerebral hemiatrophy: diagnosis and follow-up with 11C-methionine positron emission tomography

Authors: Jeehun Lee, Bo Lyun Lee, Keon Hee Yoo, Ki Woong Sung, Hong Hoe Koo, Su Jin Lee, Joon Young Choi, Kyung-Han Lee, Jung Il Lee, Hyung-Jin Shin, Ji Hye Kim, Yeon Lim Suh, Ke Hyang Lee, Munhyang Lee

Published in: Child's Nervous System | Issue 1/2009

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Abstract

Objects

Some basal ganglia germinomas are difficult to diagnose in early stage of disease due to vague initial presentation without discernable mass lesion on brain imaging. We performed this study to determine the usefulness of 11C-methionine positron emission tomography (MET PET) for the diagnosis and monitoring of disease activity.

Materials and methods

MET PET was performed in three consecutive patients; they presented with cerebral hemiatrophy without definite mass lesions on brain image. The maximum standard tracer uptake values (max SUVs) were calculated and used for the quantitative evaluation of the abnormal MET uptake. A pathological diagnosis was made after stereotactic biopsy using MET PET/computed tomography. The max SUVs significantly decreased after treatment.

Conclusion

Basal ganglia germinoma should be considered in the differential diagnosis of patients with progressive hemiparesis and hemiatrophy on magnetic resonance imaging. The MET PET was useful for diagnosis, and it can be valuable in evaluation of treatment effects and monitoring for tumor recurrence.
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Metadata
Title
Atypical basal ganglia germinoma presenting as cerebral hemiatrophy: diagnosis and follow-up with 11C-methionine positron emission tomography
Authors
Jeehun Lee
Bo Lyun Lee
Keon Hee Yoo
Ki Woong Sung
Hong Hoe Koo
Su Jin Lee
Joon Young Choi
Kyung-Han Lee
Jung Il Lee
Hyung-Jin Shin
Ji Hye Kim
Yeon Lim Suh
Ke Hyang Lee
Munhyang Lee
Publication date
01-01-2009
Publisher
Springer-Verlag
Published in
Child's Nervous System / Issue 1/2009
Print ISSN: 0256-7040
Electronic ISSN: 1433-0350
DOI
https://doi.org/10.1007/s00381-008-0674-9

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