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Child's Nervous System

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01-01-2006 | Original Paper

Recurrence in pediatric craniopharyngiomas: analysis of clinical and histological features

Authors: Deepak Kumar Gupta, B. K. Ojha, Chitra Sarkar, Ashok Kumar Mahapatra, B. S. Sharma, V. S. Mehta

Published in: Child's Nervous System | Issue 1/2006

Abstract

Objective

The purpose of this study was to investigate the recurrence pattern and significance of various clinical and histological features as predictors of recurrence in pediatric craniopharyngiomas.

Methods

A series of 116 pediatric craniopharyngiomas (68 boys and 48 girls; age range, 1.6–18 years) was reviewed. Mean follow-up period was 18.53 months. Tumors recurred in 15 patients within 96 months [mean recurrence-free survival (RFS), 12.67 months]. Of the recurrence cases, 2 had complete (mean RFS, 16 months) and 13 had subtotal tumor excision (mean RFS, 9.03 months). Histologically, an adamantinous pattern was seen in 95% of cases, whereas a papillary pattern was noted in 5%. Brain tissue was included in 41 cases. In 32 of 41 cases, brain invasion was noted, and all were of adamantinous histology. No correlation was noted of histopathological subtyping or brain invasion with recurrence.

Conclusions

The significant clinical factors associated with recurrence included extent of resection, tumor size >4 cm, and cystic tumors.

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Title: Recurrence in pediatric craniopharyngiomas: analysis of clinical and histological features
Authors: Deepak Kumar Gupta
B. K. Ojha
Chitra Sarkar
Ashok Kumar Mahapatra
B. S. Sharma
V. S. Mehta
Publication date: 01-01-2006
Publisher: Springer-Verlag
Published in: Child's Nervous System / Issue 1/2006
Print ISSN: 0256-7040
Electronic ISSN: 1433-0350
DOI: https://doi.org/10.1007/s00381-005-1171-z

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Recurrence in pediatric craniopharyngiomas: analysis of clinical and histological features

Abstract

Objective

Methods

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Objective

Methods

Conclusions

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