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Child's Nervous System
Published in: Child's Nervous System 5/2005

01-05-2005 | Case Report

Proton magnetic resonance spectroscopic imaging in pediatric pilomyxoid astrocytoma

Authors: Bayram Cirak, Alena Horská, Peter B. Barker, Peter C. Burger, Benjamin S. Carson, Anthony M. Avellino

Published in: Child's Nervous System | Issue 5/2005

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Abstract

Objects

A pilomyxoid astrocytoma (PmA) is considered to be either a more aggressive variant of a pediatric pilocytic astrocytoma (PA) or a tumor of a separate entity.

Methods

We present two cases of pediatric optic-chiasmatic PmA. Proton magnetic resonance spectroscopic imaging (MRSI) of the PmA revealed decreased concentrations of total choline (Cho), creatine (Cr), and N-acetyl aspartate (NAA). In contrast, proton MR spectra of PAs showed elevated Cho and decreased Cr and NAA signals.

Conclusion

Low metabolite concentrations in PmAs detected by MRSI may therefore help to distinguish PmAs from PAs preoperatively.
Literature
1.
Burger PC, Cohen KJ, Rosenblum MK, Tihan T (2000) Pathology of diencephalic astrocytomas [review]. Pediatr Neurosurg 32:214–219CrossRefPubMed
2.
Duyn JH, Gillen J, Sobering G, van Zijl PC, Moonen CTW (1993) Multisection proton MR spectroscopic imaging of the brain. Radiology 188:277–282PubMed
3.
Faerber EN, Roman NV (1997) Central nervous system tumors of childhood [review]. Radiol Clin North Am 35:1301–1328PubMed
4.
Fuller CE, Frankel B, Smith M et al (2001) Suprasellar monomorphous pilomyxoid neoplasm: an ultastructural analysis. Clin Neuropathol 20:256–262PubMed
5.
Horska A, Ulug AM, Melhem ER et al (2001) Proton magnetic resonance spectroscopy of choroid plexus tumors in children. J Magn Reson Imaging 14:78–82CrossRefPubMed
6.
Hwang JH, Egnaczyk GF, Ballard E, Dunn RS, Holland SK, Ball WS Jr (1998) Proton MR spectroscopic characteristics of pediatric pilocytic astrocytomas. Am J Neuroradiol 19:535–540PubMed
7.
Janisch W, Schreiber D, Martin H, Gerlach H (1985) Diencephalic pilocytic astrocytoma with clinical onset in infancy. Biological behavior and pathomorphological findings in 11 children. Zentralbl Allg Pathol 130:31–43PubMed
8.
Lazareff JA, Olmstead C, Bockhorst KH, Alger JR (1996) Proton magnetic resonance spectroscopic imaging of pediatric low-grade astrocytomas. Childs Nerv Syst 12:130–135PubMed
9.
Lazareff JA, Bockhorst KH, Curran J, Olmstead C, Alger JR (1998) Pediatric low-grade gliomas: prognosis with proton magnetic resonance spectroscopic imaging. Neurosurgery 43:809–817CrossRefPubMed
10.
Lazareff JA, Gupta RK, Alger J (1999) Variation of post-treatment H-MRSI choline intensity in pediatric gliomas. J Neurooncol 41:291–298CrossRefPubMed
11.
Miller BL, Chang L, Booth R et al (1996) In vivo 1H MRS choline: correlation with in vitro chemistry/histology. Life Sci 58:1929–1935CrossRefPubMed
12.
Soher BJ, Hurd RE, Sailasuta N, Barker PB (1996) Quantitation of automated single-voxel proton MRS using cerebral water as an internal reference. Magn Reson Med 36:335–339PubMed
13.
Soher BJ, van Zijl PC, Duyn JH, Barker PB (1996) Quantitative proton MR spectroscopic imaging of the human brain. Magn Reson Med 35:356–363PubMed
14.
Sutton LN, Wang Z, Gusnard D et al (1992) Proton magnetic resonance spectroscopy of pediatric brain tumors. Neurosurgery 31:195–202PubMed
15.
Sutton LN, Molloy PT, Sernyak H et al (1995) Long-term outcome of hypothalamic/chiasmatic astrocytomas in children treated with conservative surgery. J Neurosurg 83:583–589PubMed
16.
Sutton LN, Wang ZJ, Wehrli SL et al (1997) Proton spectroscopy of suprasellar tumors in pediatric patients. Neurosurgery 41:388–394CrossRefPubMed
17.
Tihan T, Fisher PG, Kepner JL et al (1999) Pediatric astrocytomas with monomorphous pilomyxoid features and a less favorable outcome. Neuropathol Exp Neurol 58:1061–1068PubMed
18.
Wang Z, Sutton LN, Cnaan A et al (1995) Proton MR spectroscopy of pediatric cerebellar tumors. Am J Neuroradiol 16:1821–1833
19.
Zakrzewski K, Kubicki M, Polis L, Nowoslawska E, Liberski PP (1999) Proton magnetic resonance spectroscopy of primary pediatric brain tumors: neuropathological correlation. Folia Neuropathol 37:148–151PubMed
Metadata
Title
Proton magnetic resonance spectroscopic imaging in pediatric pilomyxoid astrocytoma
Authors
Bayram Cirak
Alena Horská
Peter B. Barker
Peter C. Burger
Benjamin S. Carson
Anthony M. Avellino
Publication date
01-05-2005
Publisher
Springer-Verlag
Published in
Child's Nervous System / Issue 5/2005
Print ISSN: 0256-7040
Electronic ISSN: 1433-0350
DOI
https://doi.org/10.1007/s00381-004-1023-2

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