Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

Keynote webinar | Spotlight on medication adherence

LIVE: Thursday 27th June 2024, 18:00-19:30 (CEST)
Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.
ADVANCED SEARCH
Log in
Top
Child's Nervous System
Published in: Child's Nervous System 4/2004

01-04-2004 | Case Report

Gliosarcoma occurring 8 years after treatment for a medulloblastoma

Authors: Rohit Malde, Rakesh Jalali, Dattatraya Muzumdar, Tanuja Shet, Purna Kurkure

Published in: Child's Nervous System | Issue 4/2004

Login to get access

Abstract

Case report

We present a rare case of a gliosarcoma occurring 8 years following treatment for a medulloblastoma. The patient was diagnosed with a medulloblastoma at the age of 13 years. We considered the possibility of a radiation-induced tumour and present evidence supporting this view. The second cerebral tumour was excised and confirmed to be a gliosarcoma. The tumour bed was re-irradiated with three-dimensional conformal radiotherapy (3DCRT). She remained well for 6 months, after which there was clinicoradiological progression.

Conclusions

During long-term follow-up of patients with medulloblastomas, the possibility of radiation-induced neoplasms must be borne in mind.
Literature
1.
Anderson JR, Treip CS (1984) Radiation induced intracranial neoplasms. Cancer 53:426–429PubMed
2.
Barnard RO, Pambakian H (1980) Astrocytic differentiation in medulloblastoma. J Neurol Neurosurg Psychiatry 43:1041–1044
3.
Cohen MS, Kushner MJ, Dell S (1981) Frontal lobe astrocytoma following radiotherapy for medulloblastoma. Neurology 31:616–619PubMed
4.
Furuta T, Sugui K, Tamiya T, Matsumoto K, Ohmoto T (1998) Malignant cerebellar astrocytoma developing 15 years after radiation therapy for a medulloblastoma. Clin Neurol Neurosurg 100:56–59CrossRefPubMed
5.
Klergia E, Sher JH, Nallainathan SK, Stein SC, Sacher M (1978) Development of cerebellar malignant astrocytoma at site of a medulloblastoma treated 11 years earlier. J Neurosurg 49:445–449
6.
McLaughlin MR, Gollin SM, Lese CM, Albright AL (1998) Medulloblastoma and glioblastoma multiforme in a patient with Turcot syndrome: a case report. Surg Neurol 49:295–301CrossRefPubMed
7.
Merchant TE, Wang MH, Haida T, Lindsley KL, Finlay JL, Dunkel IJ, Rosenblum MK, Leibel SA (1996) Medulloblastoma: long-term results for patients treated with definitive radiation therapy during the computed tomography era. Int J Radiat Oncol Biol Phys 36:29–35CrossRefPubMed
8.
Osmui AK, McLendon RE, Tien RD, Friedman HS, Graham M, Hockenberger B, Halperin EC, Oakes WJ (1994) Well differentiated astrocytoma occurring 9 years after radiation therapy for medulloblastoma. Clin Neuropathol 13:281–285PubMed
9.
Pearl GS, Mirra SS, Miles ML (1980) Glioblastoma multiforme occurring 13 years after treatment of a medulloblastoma. Neurosurgery 6:546–551PubMed
10.
Safneck JR, Napier LB, Halliday WC (1993) Malignant astrocytoma of the optic nerve in a child. Can J Neurol Sci 19:498–503
11.
Schmidbauer M, Budka H, Bruckner R, Vorkapic P (1987) Glioblastoma developing at the site of a cerebellar medulloblastoma treated 6 years earlier. J Neurosurg 67:915–918PubMed
12.
Van Calenbergh F, D’Haen B, Dom R, Menten J, Plets C (1999) Secondary supratentorial anaplastic astrocytoma following treatment of medulloblastoma. Eur J Paediatr Neurol 3:177–180PubMed
Metadata
Title
Gliosarcoma occurring 8 years after treatment for a medulloblastoma
Authors
Rohit Malde
Rakesh Jalali
Dattatraya Muzumdar
Tanuja Shet
Purna Kurkure
Publication date
01-04-2004
Publisher
Springer-Verlag
Published in
Child's Nervous System / Issue 4/2004
Print ISSN: 0256-7040
Electronic ISSN: 1433-0350
DOI
https://doi.org/10.1007/s00381-003-0850-x

Other articles of this Issue 4/2004

Child's Nervous System 4/2004 Go to the issue

Announcements

April 2004

Case Report

Frontal intraparenchymal schwannoma: an unusual presentation

Commentary

Occipital extra- and intracranial lipoencephalocele associated with tectocerebellar dysraphia: case for discussion

Commentary

Occipital extra- and intracranial lipoencephalocele associated with tectocerebellar dysraphia: case for discussion

Original Paper

Moderate physical exercise increases cardiac autonomic nervous system activity in children with low heart rate variability

Original Paper

Proton magnetic resonance spectroscopy in three subacute sclerosing panencephalitis patients: correlation with clinical status