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Published in:

01-11-2003 | Original Paper

Elevated nitric oxide levels in childhood brain tumors

Authors: Chung-Lan Kao, Shih-Hwa Chiou, Hong-Shin Chen, Donald Ming-Tak Ho, Chieh-Fu Chen, Larry L.-T. Ho, Meng-Jer Lee, Tai-Tong Wong

Published in: Child's Nervous System | Issue 10-11/2003

Abstract

Objectives

One of the fundamental aspects of nitric oxide (NO) is the regulation of the inflammatory processes involved in neuronal apoptosis. Expressions of NO and NO synthase (NOS) are considered to be involved in brain tissue injuries and brain tumors. The purpose of our study was to investigate the roles of NO and inducible-form NOS (iNOS) in the pathogenesis of brain tumors.

Methods

NO levels in the cerebrospinal fluid (CSF) of 36 brain tumor patients were detected utilizing the NO-chemiluminescence method. Deparaffinized tissue sections were immunostained for the presence of antibodies against iNOS and for apoptosis using the TUNEL stain. The results were compared with 10 control patients (with epilepsy and hydrocephalus).

Conclusions

Higher levels of NO and iNOS activities may induce immune responses and neurotoxicities. This preliminary study revealed elevated NO and NOS activities with an increased amount of apoptotic processes in brain tumor tissues, which may indicate the possible roles of NO in the formation of brain tumors.

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Title: Elevated nitric oxide levels in childhood brain tumors
Authors: Chung-Lan Kao
Shih-Hwa Chiou
Hong-Shin Chen
Donald Ming-Tak Ho
Chieh-Fu Chen
Larry L.-T. Ho
Meng-Jer Lee
Tai-Tong Wong
Publication date: 01-11-2003
Publisher: Springer-Verlag
Published in: Child's Nervous System / Issue 10-11/2003
Print ISSN: 0256-7040
Electronic ISSN: 1433-0350
DOI: https://doi.org/10.1007/s00381-003-0796-z

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Elevated nitric oxide levels in childhood brain tumors

Abstract

Objectives

Methods

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Objectives

Methods

Conclusions

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