Top

Published in:

01-11-2015 | Original Article

Urinary KIM-1, NGAL and L-FABP for the diagnosis of AKI in patients with acute coronary syndrome or heart failure undergoing coronary angiography

Authors: Isidro Torregrosa, Carmina Montoliu, Amparo Urios, María Jesús Andrés-Costa, Carla Giménez-Garzó, Isabel Juan, María Jesús Puchades, María Luisa Blasco, Arturo Carratalá, Rafael Sanjuán, Alfonso Miguel

Published in: Heart and Vessels | Issue 6/2015

Abstract

Acute kidney injury (AKI) is a common complication after coronary angiography. Early biomarkers of this disease are needed since increase in serum creatinine levels is a late marker. To assess the usefulness of urinary kidney injury molecule-1 (uKIM-1), neutrophil gelatinase-associated lipocalin (uNGAL) and liver-type fatty acid-binding protein (uL-FABP) for early detection of AKI in these patients, comparing their performance with another group of cardiac surgery patients. Biomarkers were measured in 193 patients, 12 h after intervention. In the ROC analysis, AUC for KIM-1, NGAL and L-FABP was 0.713, 0.958 and 0.642, respectively, in the coronary angiography group, and 0.716, 0.916 and 0.743 in the cardiac surgery group. Urinary KIM-1 12 h after intervention is predictive of AKI in adult patients undergoing coronary angiography, but NGAL shows higher sensitivity and specificity. L-FABP provides inferior discrimination for AKI than KIM-1 or NGAL in contrast to its performance after cardiac surgery. This is the first study showing the predictive capacity of KIM-1 for AKI after coronary angiography. Further studies are still needed to answer relevant questions about the clinical utility of biomarkers for AKI in different clinical settings.

Carbonell N, Blasco M, Sanjuán R, Pérez-Sancho E, Sanchis J, Insa L, Bodí V, Núñez J, García-Ramón R, Miguel A (2007) Intravenous N-acetylcysteine for preventing contrast-induced nephropathy: a randomised trial. Int J Cardiol 115:57–62CrossRefPubMed

McCullough PA (2008) Contrast-induced acute kidney injury. J Am Coll Cardiol 51:1419–1428CrossRefPubMed

Marenzi G, De Metrio M, Rubino M, Lauri G, Cavallero A (2010) Acute hyperglycemia and contrast-induced nephropathy in primary percutaneous coronary intervention. Am Heart J 160:1170–1177CrossRefPubMed

Matejka J, Varvarovsky I, Vojtisek P, Herman A, Rozsival V, Borkova V, Kvasnicka J (2010) Prevention of contrast-induced acute kidney injury by theophylline in elderly patients with chronic kidney disease. Heart Vessels 25:536–542CrossRefPubMed

Ogita M, Sakakura K, Nakamura T, Funayama H, Wada H, Naito R, Sugawara Y, Kubo N, Ako J, Momomura S (2012) Association between deteriorated renal function and long-term clinical outcomes after percutaneous coronary intervention. Heart Vessels 27:460–467CrossRefPubMed

Rosner MH, Okusa MD (2006) Acute kidney injury associated with cardiac surgery. Clin J Am Soc Nephrol 1:19–32CrossRefPubMed

Del Duca D, Iqbal S, Rahme E, Goldberg P, De Varennes B (2007) Renal failure after cardiac surgery: timing of cardiac catheterization and other perioperative risk factors. Ann Thorac Surg 84:1264–1271CrossRefPubMed

Karkouti K, Wijeysundera DN, Yau TM, Callum JL, Cheng DC (2009) Acute kidney injury after cardiac surgery: focus on modifiable risk factors. Circulation 119:495–502CrossRefPubMed

Mariscalco G, Nicolini F, Scannapieco A, Gherli R, Serraino F, Dominici C, Renzulli A, Gherli T, Sala A, Beghi C (2013) Acute kidney injury after composite valve-graft replacement for ascending aorta aneurysms. Heart Vessels 28:229–236CrossRefPubMed

10.

Lassnigg A, Schmidlin D, Mouhieddine M (2004) Minimal changes of serum creatinine predict prognosis in patients after cardiothoracic surgery: a prospective cohort study. J Am Soc Nephrol 15:1597–1605CrossRefPubMed

11.

Stevens LA, Coresh J, Greene T, Levey AS (2006) Assessing kidney function. Measured and estimated glomerular filtration rate. N Engl J Med 354:2473–2483CrossRefPubMed

12.

Mishra J, Ma Q, Prada A, Mitsnefes M, Zahedi K (2003) Identification of neutrophil gelatinase-associated lipocalin as a novel early urinary biomarker for ischemic renal injury. J Am Soc Nephrol 14:2534–2543CrossRefPubMed

13.

Mishra J, Dent C, Tarabishi R, Mitsnefes MM, Ma Q (2005) Neutrophil gelatinase-associated lipocalin (NGAL) as a biomarker for acute renal injury after cardiac surgery. Lancet 365:1231–1238CrossRefPubMed

14.

Haase M, Bellomo R, Devarajan P, Schlattmann P, Anja Haase-Fielitz A, the NGAL Meta-analysis Investigator Group (2009) Accuracy of neutrophil gelatinase-associated lipocalin (NGAL) in diagnosis and prognosis in acute kidney injury: a systematic review and meta-analysis. Am J Kidney Dis 54:1012–1024CrossRefPubMed

15.

McIlroy DR, Wagener G, Lee HT (2010) Neutrophil gelatinase-associated lipocalin and acute kidney injury after cardiac surgery: the effect of baseline renal function on diagnostic performance. Clin J Am Soc Nephrol 5:211–219PubMedCentralCrossRefPubMed

16.

Parikh CR, Devarajan P, Zappitelli M, Sint K, Thiessen-Philbrook H, Li S, Kim RW, Koyner JL, Coca SG, Edelstein CL, Shlipak MG, Garg AX, Krawczeski CD, TRIBE-AKI Consortium (2011) Postoperative biomarkers predict acute kidney injury and poor outcomes after pediatric cardiac surgery. J Am Soc Nephrol 22:1737–1747PubMedCentralCrossRefPubMed

17.

Parikh CR, Coca SG, Thiessen-Philbrook H, Shlipak MG, Koyner JL, Wang Z, Edelstein CL, Devarajan P, Patel UD, Zappitelli M, Krawczeski CD, Passik CS, Swaminathan M, Garg AX, TRIBE-AKI Consortium (2011) Postoperative biomarkers predict acute kidney injury and poor outcomes after adult cardiac surgery. J Am Soc Nephrol 22:1748–1757PubMedCentralCrossRefPubMed

18.

Torregrosa I, Montoliu C, Urios A, Elmlili N, Puchades MJ, Solís MA, Sanjuán R, Blasco ML, Ramos C, Tomás P, Ribes J, Carratalá A, Juan I, Miguel A (2012) Early biomarkers of acute kidney failure after heart angiography or heart surgery in patients with acute coronary syndrome or acute heart failure. Nefrologia 32:44–52PubMed

19.

Liu S, Che M, Xue S, Xie B, Zhu M, Lu R, Zhang W, Qian J, Yan Y (2013) Urinary L-FABP and its combination with urinary NGAL in early diagnosis of acute kidney injury after cardiac surgery in adult patients. Biomarkers 18:95–101CrossRefPubMed

20.

Bachorzewska-Gajewska H, Poniatowski B, Dobrycki S (2009) NGAL (neutrophil gelatinase-associated lipocalin) and L-FABP after percutaneous coronary interventions due to unstable angina in patients with normal serum creatinine. Adv Med Sci 54:221–224CrossRefPubMed

21.

Malyszko J, Bachorzewska-Gajewska H, Poniatowski B, Malyszko JS, Dobrzycki S (2009) Urinary and serum biomarkers after cardiac catheterization in diabetic patients with stable angina and normal serum creatinine. Ren Fail 31:910–919CrossRefPubMed

22.

Tasanarong A, Hutayanon P, Piyayotai D (2013) Urinary neutrophil gelatinase-associated lipocalin predicts the severity of contrast-induced acute kidney injury in chronic kidney disease patients undergoing elective coronary procedures. BMC Nephrol 14:270PubMedCentralCrossRefPubMed

23.

Parikh CR, Thiessen-Philbrook H, Garg AX, Kadiyala D, Shlipak MG, Koyner JL, Edelstein CL, Devarajan P, Patel UD, Zappitelli M, Krawczeski CD, Passik CS, Coca SG, TRIBE-AKI Consortium (2013) Performance of kidney injury molecule-1 and liver fatty acid-binding protein and combined biomarkers of AKI after cardiac surgery. Clin J Am Soc Nephrol 8:1079–1088PubMedCentralCrossRefPubMed

24.

Shao X, Tian L, Xu W, Zhang Z, Wang C, Qi C, Ni Z, Mou S (2014) Diagnostic value of urinary kidney injury molecule 1 for acute kidney injury: a meta-analysis. PLoS ONE 9:e84131PubMedCentralCrossRefPubMed

25.

Susantitaphong P, Siribamrungwong M, Doi K, Noiri E, Terrin N, Jaber BL (2013) Performance of urinary liver-type fatty acid-binding protein in acute kidney injury: a meta-analysis. Am J Kidney Dis 61:430–439PubMedCentralCrossRefPubMed

26.

Katoh H, Nozue T, Kimura Y, Nakata S, Iwaki T, Kawano M, Kawashiri MA, Michishita I, Yamagishi M (2014) Elevation of urinary liver-type fatty acid-binding protein as predicting factor for occurrence of contrast-induced acute kidney injury and its reduction by hemodiafiltration with blood suction from right atrium. Heart Vessels 29:191–197CrossRefPubMed

27.

Fujita D, Takahashi M, Doi K, Abe M, Tazaki J, Kiyosue A, Myojo M, Ando J, Fujita H, Noiri E, Sugaya T, Hirata Y, Komuro I (2014) Response of urinary liver-type fatty acid-binding protein to contrast media administration has a potential to predict one-year renal outcome in patients with ischemic heart disease. Heart Vessels. doi:10.1007/s00380-014-0484-9

28.

Vanmassenhove J, Vanholder R, Nagler E, Van Biesen W (2013) Urinary and serum biomarkers for the diagnosis of acute kidney injury: an in-depth review of the literature. Nephrol Dial Transplant 28:254–273CrossRefPubMed

29.

Bellomo R, Ronco C, Kellum JA, Mehta RL, Palevsky P, the ADQI Workgroup (2004) Acute renal failure-definition, outcome measures, animal models, fluid therapy and information technology needs: the second international consensus conference of the acute dialysis quality initiative (ADQI) group. Crit Care 8:R204–R212PubMedCentralCrossRefPubMed

30.

World Medical Association (1997) Declaration of Helsinki: recommendations guiding medical physicians in biomedical research involving human subjects. JAMA 277:925–926

31.

Malyszko J, Bachorzewska-Gajewska H, Malyszko JS, Pawlak K, Dobrzycki S (2008) Serum neutrophil gelatinase-associated lipocalin as a marker of renal function in hypertensive and normotensive patients with coronary artery disease. Nephrology (Carlton) 13:153–156CrossRef

32.

Przybylowski P, Malyszko J, Malyszko J (2010) Kidney function assessed by eGFR, cystatin C and NGAL (neutrophil gelatinase-associated lipocalin) in relation to age in heart allograft recipients. Med Sci Monit 16:440–444

33.

Martensson J, Bell M, Oldner A, Xu S, Venge P, Martling CR (2010) Neutrophil gelatinase-associated lipocalin in adult septic patients with and without acute kidney injury. Intensiv Care Med 36:1333–1340CrossRef

34.

Koyner JL, Vaidya VS, Bennett MR, Ma Q, Worcester E (2010) Urinary biomarkers in the clinical prognosis and early detection of acute kidney injury. Clin J Am Soc Nephrol 5:2154–2165PubMedCentralCrossRefPubMed

35.

Ma X, Zhang BR, Li DT (2011) Value of urinary kidney injury molecule-1 protein in early diagnosis of radiocontrast- induced nephropathy in rats. Nan Fang Yi Ke Da Xue Xue Bao 31:357–360PubMed

36.

Ralib AM, Pickering JW, Shaw GM, Devarajan P, Edelstein CL, Bonventre JV, Endre ZH (2012) Test characteristics of urinary biomarkers depend on quantitation method in acute kidney injury. J Am Soc Nephrol 23:322–333CrossRefPubMed

37.

Singer E, Elger A, Elitok S, Kettritz R, Nickolas TL, Barasch J, Luft FC, Schmidt-Ott KM (2011) Urinary neutrophil gelatinase-associated lipocalin distinguishes pre-renal from intrinsic renal failure and predicts outcomes. Kidney Int 80:405–414CrossRefPubMed

38.

Doi K, Katagiri D, Negishi K, Hasegawa S, Hamasaki Y, Fujita T, Matsubara T, Ishii T, Yahagi N, Sugaya T, Noiri E (2012) Mild elevation of urinary biomarkers in prerenal acute kidney injury. Kidney Int 82:1114–1120CrossRefPubMed

39.

Nejat M, Pickering JW, Devarajan P, Bonventre JV, Edelstein CL, Walker RJ, Endre ZH (2012) Some biomarkers of acute kidney injury are increased in pre-renal acute injury. Kidney Int 81:1254–1262PubMedCentralCrossRefPubMed

Title: Urinary KIM-1, NGAL and L-FABP for the diagnosis of AKI in patients with acute coronary syndrome or heart failure undergoing coronary angiography
Authors: Isidro Torregrosa
Carmina Montoliu
Amparo Urios
María Jesús Andrés-Costa
Carla Giménez-Garzó
Isabel Juan
María Jesús Puchades
María Luisa Blasco
Arturo Carratalá
Rafael Sanjuán
Alfonso Miguel
Publication date: 01-11-2015
Publisher: Springer Japan
Published in: Heart and Vessels / Issue 6/2015
Print ISSN: 0910-8327
Electronic ISSN: 1615-2573
DOI: https://doi.org/10.1007/s00380-014-0538-z

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Urinary KIM-1, NGAL and L-FABP for the diagnosis of AKI in patients with acute coronary syndrome or heart failure undergoing coronary angiography

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Please log in to get access to this content

Other articles of this Issue 6/2015

Maximal acetylcholine dose of 200 μg into the left coronary artery as a spasm provocation test: comparison with 100 μg of acetylcholine

Comparison of long-term clinical outcomes between sirolimus- and paclitaxel-eluting stents in real-world clinical practice

Characteristics and clinical relevance of late gadolinium enhancement in cardiac magnetic resonance in patients with systemic sclerosis

The effects of weight gain after smoking cessation on atherogenic α1-antitrypsin–low-density lipoprotein

Effects of the topographical extent of coronary artery ectasia on coronary blood flow in patients with aortic aneurysms

Usefulness of serum bilirubin levels as a biomarker for long-term clinical outcomes after percutaneous coronary intervention