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01-09-2013 | Original Article

Relationship between atrial conduction delay and obstructive sleep apnea

Authors: Ken-ichi Maeno, Takatoshi Kasai, Satoshi Kasagi, Fusae Kawana, Sugao Ishiwata, Minoru Ohno, Tetsu Yamaguchi, Koji Narui

Published in: Heart and Vessels | Issue 5/2013

Abstract

Prolonged P-wave duration, indicating atrial conduction delay, is a marker of left atrial abnormality and is reported as a potent precursor of atrial fibrillation (AF). Several studies have shown that obstructive sleep apnea (OSA) is associated with AF. We evaluated the relationship between OSA and prolonged P-wave duration. Consecutive subjects who underwent overnight polysomnography and showed a normal sinus rhythm, had no history of AF or ischemic heart disease, and showed no evidence of heart failure were enrolled. Apnea–hypopnea index (AHI) is defined as the number of apnea and hypopnea events per hour of sleep. P-wave duration was determined on the basis of the mean duration of three consecutive beats in lead II from a digitally stored electrocardiogram. A total of 250 subjects (middle-aged, predominantly male, mildly obese, with a mean P-wave duration of 106 ms) were enrolled. In addition to age, male gender, body mass index (BMI), hypertension, dyslipidemia, and uric acid and creatinine levels, AHI (r = 0.56; P < 0.001) had significant univariable relationship with P-wave duration. Multivariate regression analysis showed that age, BMI, male gender, and AHI (partial correlation coefficient, 0.47; P < 0.001) were significantly independently correlated to P-wave duration. Severity of OSA is significantly associated with delayed atrial conduction time. Obstructive sleep apnea may lead to progression of atrial remodeling as an AF substrate.

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Title: Relationship between atrial conduction delay and obstructive sleep apnea
Authors: Ken-ichi Maeno
Takatoshi Kasai
Satoshi Kasagi
Fusae Kawana
Sugao Ishiwata
Minoru Ohno
Tetsu Yamaguchi
Koji Narui
Publication date: 01-09-2013
Publisher: Springer Japan
Published in: Heart and Vessels / Issue 5/2013
Print ISSN: 0910-8327
Electronic ISSN: 1615-2573
DOI: https://doi.org/10.1007/s00380-012-0288-8

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Relationship between atrial conduction delay and obstructive sleep apnea

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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