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Published in: World Journal of Urology 11/2021

01-11-2021 | Benign Prostatic Hypertrophy | Invited Review

Bladder neck stenosis after transurethral prostate surgery: a systematic review and meta-analysis

Authors: Daniele Castellani, Marcelo Langer Wroclawski, Giacomo Maria Pirola, Vineet Gauhar, Emanuele Rubilotta, Vinson Wai-Shun Chan, Bryan Kwun-Chung Cheng, Marilena Gubbiotti, Andrea Benedetto Galosi, Thomas R. W. Herrmann, Jeremy Yuen-Chun Teoh

Published in: World Journal of Urology | Issue 11/2021

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Abstract

Purpose

Bladder neck stenosis (BNS) is a long-term complication of surgical procedures for benign prostatic hyperplasia (BPH). We performed a systematic literature review and a meta-analysis of the incidence of BNS after transurethral procedures for BPH.

Methods

We performed a systemic literature review using MEDLINE, EMBASE, and Cochrane Central Controlled Register of Trials. We accepted only randomized trials comparing transurethral resection of the prostate (TURP) vs. other transurethral surgery for BPH that were grouped in Ablation vs. Enucleation modalities. The incidences of BNS were pooled using the Cochran–Mantel–Haenszel Method with the random effect model and expressed as Risk Ratios, 95% Confidence Intervals, and p values. Study heterogeneity was assessed utilizing the I2 value.

Results

72 studies were identified for meta-analysis, 46 comparing TURP vs. Ablation and 26 TURP vs. Enucleation. The pooled incidence of BNS was 1.3% after TURP, 0.66% after enucleation and 1.2% after Ablation. The incidence of BNS was higher after TURP than after Enucleation but the difference was not statistically significant (RR 1.75 95% CI 0.81–3.79, p = 0.16). There was no significant heterogeneity among the studies (I2 0%, Chi2 4.11, p = 0.90). The incidence of BNS was higher after TURP than after Ablation, but the difference was not statistically significant (RR 1.31, 95% CI 0.82–2.11, p = 0.26) with no significant heterogeneity (I2 0%, Chi2 21.1, p = 0.51).

Conclusion

Our study showed no difference in the rate of BNS incidence among randomized trials comparing TURP vs. Ablation vs. Enucleation and can be used as a reference to counsel patients undergoing BPH surgery.
Appendix
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Metadata
Title
Bladder neck stenosis after transurethral prostate surgery: a systematic review and meta-analysis
Authors
Daniele Castellani
Marcelo Langer Wroclawski
Giacomo Maria Pirola
Vineet Gauhar
Emanuele Rubilotta
Vinson Wai-Shun Chan
Bryan Kwun-Chung Cheng
Marilena Gubbiotti
Andrea Benedetto Galosi
Thomas R. W. Herrmann
Jeremy Yuen-Chun Teoh
Publication date
01-11-2021
Publisher
Springer Berlin Heidelberg
Published in
World Journal of Urology / Issue 11/2021
Print ISSN: 0724-4983
Electronic ISSN: 1433-8726
DOI
https://doi.org/10.1007/s00345-021-03718-1

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