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Published in: World Journal of Urology 4/2019

01-04-2019 | Topic Paper

Female urethroplasty: contemporary thinking

Authors: C. West, A. Lawrence

Published in: World Journal of Urology | Issue 4/2019

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Abstract

Purpose

Female urethral stricture disease is a rare entity. To date, its diagnosis and treatment have been poorly studied, with small numbers, and variable definitions of success. With growing interest in this area of reconstructive urology, there is an increased number of surgical techniques. In this article, we review current trends, definitions, etiologies and surgical techniques available for management of FUSD.

Method

We completed a review of publications in: English; Pubmed, and Google scholar. Key words identified for review were, female urethra stricture, female urethroplasty and female urethral dilation, female pelvic fracture, and female urethral reconstruction. Papers were reviewed, and references of relevant papers reviewed.

Results

Iatrogenic injury is the most common cause of female urethral stricture disease. Assessment requires a thorough patient history, examination and either flexible cystoscopy and/or fluoroscopic urodynamics to determine the most appropriate surgical approach for stricture repair. Multiple open urethroplasty techniques are described with various grafts and flaps, with good medium-term success. Minimally invasive techniques remain well-employed but have poor long-term success, with increased failure with multiple attempts at treatment.

Conclusion

Female urethral stricture disease is a complex clinical entity that requires a measured and thorough evaluation. Individualized approach should be undertaken reviewing the patient’s symptoms, the stricture’s etiology, surrounding vaginal tissue health and stricture location. Promising medium-term success rates with vaginal flaps and buccal mucosal graft urethroplasty have been reported, with disappointing long-term results from repeated urethral dilation. Further research comparing techniques and defining successful long-term outcomes is required.
Literature
1.
go back to reference Spilotros M, Malde S, Solomon E, Grewal M, Mukhtar BM, Pakzad M, Hamid R, Ockrim JL, Greenwell TJ (2017) Female urethral stricture: a contemporary series. World J Urol 35:991–995CrossRefPubMed Spilotros M, Malde S, Solomon E, Grewal M, Mukhtar BM, Pakzad M, Hamid R, Ockrim JL, Greenwell TJ (2017) Female urethral stricture: a contemporary series. World J Urol 35:991–995CrossRefPubMed
2.
go back to reference Smith AL, Ferlise VJ, Rovner ES (2009) Female urethral strictures: successful management with long-term clean intermittent catheterization after urethral dilatation. BJU Int 98:96–99CrossRef Smith AL, Ferlise VJ, Rovner ES (2009) Female urethral strictures: successful management with long-term clean intermittent catheterization after urethral dilatation. BJU Int 98:96–99CrossRef
3.
go back to reference Osman NI, Mangera A, Chapple CR (2013) A systematic review of surgical techniques used in the treatment of female urethral stricture. Eur Urol 64:965–973CrossRefPubMed Osman NI, Mangera A, Chapple CR (2013) A systematic review of surgical techniques used in the treatment of female urethral stricture. Eur Urol 64:965–973CrossRefPubMed
4.
5.
go back to reference Gormley EA (2010) Vaginal flap urethroplasty for female urethral stricture disease. Neurourol Urodyn 29:S42–S45CrossRefPubMed Gormley EA (2010) Vaginal flap urethroplasty for female urethral stricture disease. Neurourol Urodyn 29:S42–S45CrossRefPubMed
6.
go back to reference Hoag N, Chee J (2017) Surgical management of female urethral strictures. Transl Adrol Urol 6(Suppl 2):S76–S80CrossRef Hoag N, Chee J (2017) Surgical management of female urethral strictures. Transl Adrol Urol 6(Suppl 2):S76–S80CrossRef
7.
go back to reference Osman NI, Chapple CR (2015) Contemporary surgical management of female urethral stricture disease. Curr Opin Urol 25:341–345PubMed Osman NI, Chapple CR (2015) Contemporary surgical management of female urethral stricture disease. Curr Opin Urol 25:341–345PubMed
8.
go back to reference Blaivas JG, Satos JA, Tsui JF et al (2012) Management of urethral stricture in women. J Urol 188:1778–1782CrossRefPubMed Blaivas JG, Satos JA, Tsui JF et al (2012) Management of urethral stricture in women. J Urol 188:1778–1782CrossRefPubMed
9.
go back to reference Petrou SP, Rogers AE, Parker AS, Green KM, McRoberts JW (2012) Dorsal vaginal graft urethroplasty for female urethral stricture disease. BJU Int 110:E1090–E1095CrossRefPubMed Petrou SP, Rogers AE, Parker AS, Green KM, McRoberts JW (2012) Dorsal vaginal graft urethroplasty for female urethral stricture disease. BJU Int 110:E1090–E1095CrossRefPubMed
10.
go back to reference Anast J, Brandes SB, Klutke C (2008) Female urethral reconstruction In: Brandes SB (ed) Urethral reconstructive surgery, Humana Press, Totowa, p 303CrossRef Anast J, Brandes SB, Klutke C (2008) Female urethral reconstruction In: Brandes SB (ed) Urethral reconstructive surgery, Humana Press, Totowa, p 303CrossRef
11.
go back to reference Romman AN, Alhalabi F, Zimmerman PE (2012) Distal intramural urethral pathology in women. J Urol 188:1218–1223CrossRefPubMed Romman AN, Alhalabi F, Zimmerman PE (2012) Distal intramural urethral pathology in women. J Urol 188:1218–1223CrossRefPubMed
12.
go back to reference Popat S, Zimmern P (2016) Long-term management of luminal urethral stricture in women. Int Urogynaecol 27:1735–1741CrossRef Popat S, Zimmern P (2016) Long-term management of luminal urethral stricture in women. Int Urogynaecol 27:1735–1741CrossRef
13.
14.
go back to reference Montorsi F, Salonia A, Centemero A et al (2002) Vestibular flap urethroplasty for strictures of the female urethra—impact on symptoms and flow patterns. Urol Int 69:12–16CrossRefPubMed Montorsi F, Salonia A, Centemero A et al (2002) Vestibular flap urethroplasty for strictures of the female urethra—impact on symptoms and flow patterns. Urol Int 69:12–16CrossRefPubMed
15.
go back to reference Simonato A, Varca V, Esposito M, Carmignani G (2010) Vaginal flap urethroplasty for wide female stricture disease. J Urol 184:1381–1385CrossRefPubMed Simonato A, Varca V, Esposito M, Carmignani G (2010) Vaginal flap urethroplasty for wide female stricture disease. J Urol 184:1381–1385CrossRefPubMed
16.
go back to reference Onol FF, Atar B, Osman K, Erdem MR, Onol SY (2011) Techniques and results of urethroplasty for female urethral strictures: our experience with 17 patients. Urology 77:1318–1324CrossRefPubMed Onol FF, Atar B, Osman K, Erdem MR, Onol SY (2011) Techniques and results of urethroplasty for female urethral strictures: our experience with 17 patients. Urology 77:1318–1324CrossRefPubMed
17.
go back to reference Tanello M, Frego E, Simeone C, Cosciani Cunico S (2002) Use of pedicle flap from the labia minora for the repair of female urethral strictures. Urol Int 69:95–98CrossRefPubMed Tanello M, Frego E, Simeone C, Cosciani Cunico S (2002) Use of pedicle flap from the labia minora for the repair of female urethral strictures. Urol Int 69:95–98CrossRefPubMed
18.
go back to reference Falandry L, Xie D, Liang Z, Seydou M, Alphonsi R (1999) Utilisation of a pedicled labial flap, single or double face, for the management of post-obstetric urethral damage. J Gynecol Obstet Biol Reprod (Paris) 28:151–161 Falandry L, Xie D, Liang Z, Seydou M, Alphonsi R (1999) Utilisation of a pedicled labial flap, single or double face, for the management of post-obstetric urethral damage. J Gynecol Obstet Biol Reprod (Paris) 28:151–161
19.
go back to reference Xu YM, Sa YL, Fu Q, Zhang J, Xie H, Jin SB (2009) Transpubic access using pedicle tubularised labial urethroplasty for the treatment of urethral strictures associated with urethrovaginal fistulas secondary to pelvic fracture. Eur Urol 56:193–200CrossRefPubMed Xu YM, Sa YL, Fu Q, Zhang J, Xie H, Jin SB (2009) Transpubic access using pedicle tubularised labial urethroplasty for the treatment of urethral strictures associated with urethrovaginal fistulas secondary to pelvic fracture. Eur Urol 56:193–200CrossRefPubMed
20.
go back to reference Onol FF, Onol SY, Tahra A, Boylu U (2014) Ventral inlay labia minora graft urethroplasty for the management of female urethral strictures. Urology 83:460–464CrossRefPubMed Onol FF, Onol SY, Tahra A, Boylu U (2014) Ventral inlay labia minora graft urethroplasty for the management of female urethral strictures. Urology 83:460–464CrossRefPubMed
21.
go back to reference Rehder P, Glodny B, Pichler R, Exeli L, Kerschbaumer A, Mitterberger MJ (2010) Dorsal urethroplasty with labia minor skin graft for female urethral strictures. BJU Int 106:1211–1214CrossRefPubMed Rehder P, Glodny B, Pichler R, Exeli L, Kerschbaumer A, Mitterberger MJ (2010) Dorsal urethroplasty with labia minor skin graft for female urethral strictures. BJU Int 106:1211–1214CrossRefPubMed
22.
go back to reference Gozzi C, Roosen A, Bastian PJ, Karl A, Stief C, Tritschler S (2010) Volar only urethroplasty for reconstruction of female urethra in recurrent stricture disease. BJU Int 107:1964–1966CrossRefPubMed Gozzi C, Roosen A, Bastian PJ, Karl A, Stief C, Tritschler S (2010) Volar only urethroplasty for reconstruction of female urethra in recurrent stricture disease. BJU Int 107:1964–1966CrossRefPubMed
23.
go back to reference Tsivian A, Sidi A (2006) Dorsal graft urethroplasty for female urethral stricture. J Urol 176:611–613CrossRefPubMed Tsivian A, Sidi A (2006) Dorsal graft urethroplasty for female urethral stricture. J Urol 176:611–613CrossRefPubMed
24.
go back to reference Migliari R, Leone P, Berdondini E, De Angelis M, Barbagli G, Palminteri E (2006) Dorsal buccal mucosal graft urethroplasty for female urethral strictures. J Urol 176:1473–1476CrossRefPubMed Migliari R, Leone P, Berdondini E, De Angelis M, Barbagli G, Palminteri E (2006) Dorsal buccal mucosal graft urethroplasty for female urethral strictures. J Urol 176:1473–1476CrossRefPubMed
25.
go back to reference Berglund RK, Vasavada S, Angermeier K, Rackley R (2006) Buccal mucosa graft urethroplasty for recurrent stricture of female urethra. Urology 67:1069–1071CrossRefPubMed Berglund RK, Vasavada S, Angermeier K, Rackley R (2006) Buccal mucosa graft urethroplasty for recurrent stricture of female urethra. Urology 67:1069–1071CrossRefPubMed
26.
go back to reference Sharma GK, Pandey A, Bansal H, Swain S, Das SK, Trivedi S, Dwivedi US, Singh PB (2009) Dorsal onlay lingual mucosal graft urethroplasty for urethral strictures in women. BJU Int 105:1309–1312CrossRefPubMed Sharma GK, Pandey A, Bansal H, Swain S, Das SK, Trivedi S, Dwivedi US, Singh PB (2009) Dorsal onlay lingual mucosal graft urethroplasty for urethral strictures in women. BJU Int 105:1309–1312CrossRefPubMed
27.
go back to reference Castillo OA, Sepulveda F, Feria-Flores MA (2009) Urethroplasty with dorsal oral mucosa graft in female urethral stenosis. Actas Urol Esp 35:246–249 (in Spanish) CrossRef Castillo OA, Sepulveda F, Feria-Flores MA (2009) Urethroplasty with dorsal oral mucosa graft in female urethral stenosis. Actas Urol Esp 35:246–249 (in Spanish) CrossRef
28.
go back to reference Kowalik C, Stoffel JT, Zinman L, Vanni AJ, Buckley JC (2014) Intermediate outcomes after female urethral reconstruction: graft vs flap. Urology 83:1181–1185CrossRefPubMed Kowalik C, Stoffel JT, Zinman L, Vanni AJ, Buckley JC (2014) Intermediate outcomes after female urethral reconstruction: graft vs flap. Urology 83:1181–1185CrossRefPubMed
29.
go back to reference Goel A, Paul S, Dalela D, Pushpalata S, Narayan S, Singh V (2014) Dorsal onlay buccal mucosal graft urethroplasty in female urethral stricture disease: a single-centre experience. Int Urogynaecol J 25:525–530CrossRef Goel A, Paul S, Dalela D, Pushpalata S, Narayan S, Singh V (2014) Dorsal onlay buccal mucosal graft urethroplasty in female urethral stricture disease: a single-centre experience. Int Urogynaecol J 25:525–530CrossRef
30.
go back to reference Powell CR, Daniels D (2017) Dorsal onlay buccal urethroplasty in the female is associated with high quality of life using validated lower urinary tract symptom instruments. Urol Pract 4:48–53CrossRef Powell CR, Daniels D (2017) Dorsal onlay buccal urethroplasty in the female is associated with high quality of life using validated lower urinary tract symptom instruments. Urol Pract 4:48–53CrossRef
31.
go back to reference Hoag N, Gani J, Chee J (2016) Vaginal-sparing ventral buccal mucosal graft urethroplasty for female urethral stricture: a novel modification of surgical technique. Investig Clin Urol 57:298–302CrossRefPubMedPubMedCentral Hoag N, Gani J, Chee J (2016) Vaginal-sparing ventral buccal mucosal graft urethroplasty for female urethral stricture: a novel modification of surgical technique. Investig Clin Urol 57:298–302CrossRefPubMedPubMedCentral
33.
go back to reference Tanagho EA (1976) Urethrosphincteric reconstruction for congenitally absent urethra. J Urol 116:237–242CrossRefPubMed Tanagho EA (1976) Urethrosphincteric reconstruction for congenitally absent urethra. J Urol 116:237–242CrossRefPubMed
34.
go back to reference Hemal AK, Dorairaja L, Gupta NP (2000) Posttraumatic complete and partial loss of urethra with pelvic fracture in girls: an appraisal of management. J Urol 163:282–287CrossRefPubMed Hemal AK, Dorairaja L, Gupta NP (2000) Posttraumatic complete and partial loss of urethra with pelvic fracture in girls: an appraisal of management. J Urol 163:282–287CrossRefPubMed
35.
go back to reference Flisser AJ, Blaivas JG (2003) Outcome of urethral reconstructive surgery in a series of 74 women. J Urol 169:2246–2249CrossRefPubMed Flisser AJ, Blaivas JG (2003) Outcome of urethral reconstructive surgery in a series of 74 women. J Urol 169:2246–2249CrossRefPubMed
36.
go back to reference Versteegden LRM, de Jonge PKJD, IntHout J et al (2017) Tissue engineering of the urethra: a systematic review and meta-analysis of preclinical and clinical studies. Eur Urol 72(4):594–606CrossRefPubMed Versteegden LRM, de Jonge PKJD, IntHout J et al (2017) Tissue engineering of the urethra: a systematic review and meta-analysis of preclinical and clinical studies. Eur Urol 72(4):594–606CrossRefPubMed
37.
go back to reference Davis NF, Cunnane EM, O’Brien FJ, Mulvihill JJ, Walsh MT (2018) Tissue engineered extracellular matrices (ECMs) in urology: evolution and future directions. Surgeon 16(1):55–65CrossRefPubMed Davis NF, Cunnane EM, O’Brien FJ, Mulvihill JJ, Walsh MT (2018) Tissue engineered extracellular matrices (ECMs) in urology: evolution and future directions. Surgeon 16(1):55–65CrossRefPubMed
38.
go back to reference Mantovani F, Trinchieri A, Castelnuovo C, Romano AL, Pisani E (2003) Reconstructive urology using porcine acellular matrix. Eur Urol 44(5):600–602CrossRefPubMed Mantovani F, Trinchieri A, Castelnuovo C, Romano AL, Pisani E (2003) Reconstructive urology using porcine acellular matrix. Eur Urol 44(5):600–602CrossRefPubMed
39.
go back to reference Ansari S, Karram M (2017) Two cases of female urethral reconstruction with acellular porcine urinary bladder matrix. Int Urogynecol J 28:1257–1260CrossRefPubMed Ansari S, Karram M (2017) Two cases of female urethral reconstruction with acellular porcine urinary bladder matrix. Int Urogynecol J 28:1257–1260CrossRefPubMed
40.
go back to reference Rutherford AJ, Hinshaw K, Essenhigh DM, Neal DE (1988) Urethral dilatation compared with cystoscopy alone in the treatment of women with recurrent frequency and dysuria. BJU Int 61:500–504CrossRef Rutherford AJ, Hinshaw K, Essenhigh DM, Neal DE (1988) Urethral dilatation compared with cystoscopy alone in the treatment of women with recurrent frequency and dysuria. BJU Int 61:500–504CrossRef
41.
go back to reference Santucci RA, Payne CK, Anger JT, Saigal CS (2008) Office dilatation of the female urethra: a quality of care problem in the field of urology. J Urol 180:2068–2075CrossRefPubMedPubMedCentral Santucci RA, Payne CK, Anger JT, Saigal CS (2008) Office dilatation of the female urethra: a quality of care problem in the field of urology. J Urol 180:2068–2075CrossRefPubMedPubMedCentral
43.
go back to reference Santucci R, Eisenberg L (2010) Urethrotomy has a much lower success rate than previously reported. J Urol 183(5):1859–1862CrossRefPubMed Santucci R, Eisenberg L (2010) Urethrotomy has a much lower success rate than previously reported. J Urol 183(5):1859–1862CrossRefPubMed
44.
go back to reference Radwan MH, Abou Farha MO, Soliman MG et al (2013) Outcome of female urethral reconstruction: a 12-year experience. WJU 3:991–995 Radwan MH, Abou Farha MO, Soliman MG et al (2013) Outcome of female urethral reconstruction: a 12-year experience. WJU 3:991–995
Metadata
Title
Female urethroplasty: contemporary thinking
Authors
C. West
A. Lawrence
Publication date
01-04-2019
Publisher
Springer Berlin Heidelberg
Published in
World Journal of Urology / Issue 4/2019
Print ISSN: 0724-4983
Electronic ISSN: 1433-8726
DOI
https://doi.org/10.1007/s00345-018-2564-4

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