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World Journal of Urology

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01-05-2018 | Topic Paper

Internal Fusion: exact correlation of transrectal ultrasound images of the prostate by detailed landmarks over time for targeted biopsies or follow-up

Authors: Yanqi Xie, Theodoros Tokas, Björn Grabski, Tillmann Loch

Published in: World Journal of Urology | Issue 5/2018

Abstract

Purpose

Innovative imaging modalities are applied for diagnosing and follow-up of prostate cancer (PCa). To perform authentic targeted biopsies and evaluate prostate changes, it is essential to reliably identify and hit targets in their true anatomical location over time. A newly described image correlation method (Internal Fusion) allows precise correlation of serial transrectal ultrasound (TRUS) images in vitro and vivo. Identifiable morphologic structures such as prostatic calcifications define internal anchor points (Internal Landmarks) to facilitate exact correlation.

Methods

After verification of Internal Fusion in vitro, 83 patients were included from January to August 2017 with at least one prior series of 5-mm spaced TRUS images stored as computed tomographic (US-CT) online data set. Two experienced operators collected new images in correlation with each cross-section of the previous examinations based on Internal Landmarks.

Results

Of the 83 patients, fifty (60%) had prior negative biopsies. Fourteen (17%) wished US-CT targeted biopsies and PCa were detected in 7/14 patients (50%). Overall, accurate imaging correlations were attained in 369/397 slices (93%). In initial and repeat biopsy, 31/31 and 35/35 images could be correlated detecting PCa in 5/8 (63%) and 2/6 patients (33%). The longest observation of prostate changes over time (Trend Monitoring) with accurate image correlation was 8 years and 6 months.

Conclusions

Internal Fusion by Internal Landmarks ensures exact correlation in long-term follow-up. It is possible to precisely monitor trends in prostate tissue changes. In case of PCa suspicion, biopsies could be targeted with high accuracy by Internal Fusion, even over time.

Mottet N, Bellmunt J, Bolla M, Briers E, Cumberbatch MG, De Santis M, Fossati N, Gross T, Henry AM, Joniau S, Lam TB, Mason MD, Matveev VB, Moldovan PC, van den Bergh RCN, T Broeck Van den, van der Poel HG, van der Kwast TH, Rouvière O, Schoots IG, Wiegel T, Cornford P (2016) EAU-ESTRO-SIOG guidelines on prostate cancer. part 1: screening, diagnosis, and local treatment with curative intent. Eur Urol 71(4):618–629. https://doi.org/10.1016/j.eururo.2016.08.003 CrossRefPubMed

Hara R, Jo Y, Fujii T, Kondo N, Yokoyoma T, Miyaji Y, Nagai A (2008) Optimal approach for prostate cancer detection as initial biopsy: prospective randomized study comparing transperineal versus transrectal systematic 12-core biopsy. Urology 71(2):191–195. https://doi.org/10.1016/j.urology.2007.09.029 CrossRefPubMed

Haas GP, Delongchamps NB, Jones RF, Chandan V, Serio AM, Vickers AJ, Jumbelic M, Threatte G, Korets R, Lilja H, de la Roza G (2007) Needle biopsies on autopsy prostates: sensitivity of cancer detection based on true prevalence. J Natl Cancer Inst 99(19):1484–1489. https://doi.org/10.1093/jnci/djm153 CrossRefPubMed

Singh H, Canto EI, Shariat SF, Kadmon DOV, Miles BJ, Wheeler TM, Slawin KM (2004) Predictors of Prostate cancer after initial negative systematic 12 core biopsy. J Urol 171(5):1850–1854. https://doi.org/10.1097/01.ju.0000119667.86071.e7 CrossRefPubMed

Terris MK, McNeal JE, Stamey TA (1992) Detection of clinically significant prostate cancer by transrectal ultrasound-guided systematic biopsies. J Urol 148(3):829–832. https://doi.org/10.1016/S0022-5347(17)36735-6 CrossRefPubMed

Pummer K, Rieken M, Augustin H, Gutschi T, Shariat SF (2014) Innovations in diagnostic imaging of localized prostate cancer. World J Urol 32(4):881–890. https://doi.org/10.1007/s00345-013-1172-6 CrossRefPubMed

Loch T, Leuschner I, Genberg C, Weichert-Jacobsen K, Küppers F, Yfantis E, Evans M, Tsarev V, Stöckle M (1999) Artificial neural network analysis (ANNA) of prostatic transrectal ultrasound. Prostate 39(3):198–204. https://doi.org/10.1002/(SICI)1097-0045(19990515)39:3<198:AID-PROS8>3.0.CO;2-X CrossRefPubMed

Epstein JI (2011) Prognostic significance of tumor volume in radical prostatectomy and needle biopsy specimens. J Urol 186(3):790–797. https://doi.org/10.1016/j.juro.2011.02.2695 CrossRefPubMed

Loch T (2007) Computerized transrectal ultrasound (C-TRUS) of the prostate: detection of cancer in patients with multiple negative systematic random biopsies. World J Urol 25(4):375–380. https://doi.org/10.1007/s00345-007-0181-8 CrossRefPubMed

10.

Stamey TA, Freiha FS, McNeal JE, Redwine EA, Whittemore AS, Schmid H-P (1993) Localized prostate cancer. Relationship of tumor volume to clinical significance for treatment of prostate cancer. Cancer 71(S3):933–938. https://doi.org/10.1002/1097-0142(19930201)71:3+<933:AID-CNCR2820711408>3.0.CO;2-L CrossRefPubMed

11.

Ploussard G, Epstein JI, Montironi R, Carroll PR, Wirth M, Grimm M-O, Bjartell AS, Montorsi F, Freedland SJ, Erbersdobler A, van der Kwast TH (2011) The contemporary concept of significant versus insignificant prostate cancer. Eur Urol 60(2):291–303. https://doi.org/10.1016/j.eururo.2011.05.006 CrossRefPubMed

12.

Lee HY, Lee HJ, Byun S-S, Lee SE, Hong SK, Kim SH (2009) Classification of focal prostatic lesions on transrectal ultrasound (TRUS) and the accuracy of TRUS to diagnose prostate cancer. Korean J Radiol 10(3):244–251. https://doi.org/10.3348/kjr.2009.10.3.244 CrossRefPubMedPubMedCentral

13.

Cash H, Günzel K, Maxeiner A, Stephan C, Fischer T, Durmus T, Miller K, Asbach P, Haas M, Kempkensteffen C (2016) Prostate cancer detection on transrectal ultrasonography-guided random biopsy despite negative real-time magnetic resonance imaging/ultrasonography fusion-guided targeted biopsy: reasons for targeted biopsy failure. BJU Int 118(1):35–43. https://doi.org/10.1111/bju.13327 CrossRefPubMed

14.

Sarkar S, Das S (2016) A Review of imaging methods for prostate cancer detection. Biomed Eng Comput Biol 7(Suppl 1):1–15. https://doi.org/10.4137/BECB.S34255 PubMedPubMedCentral

15.

Hadaschik BA, Kuru TH, Tulea C, Rieker P, Popeneciu IV, Simpfendörfer T, Huber J, Zogal P, Teber D, Pahernik S, Roethke M, Zamecnik P, Roth W, Sakas G, Schlemmer H-P, Hohenfellner M (2011) A novel stereotactic prostate biopsy system integrating pre-interventional magnetic resonance imaging and live ultrasound fusion. The Journal of Urology 186(6):2214–2220. https://doi.org/10.1016/j.juro.2011.07.102 CrossRefPubMed

16.

Kuru TH, Roethke MC, Seidenader J, Simpfendörfer T, Boxler S, Alammar K, Rieker P, Popeneciu VI, Roth W, Pahernik S, Schlemmer H-P, Hohenfellner M, Hadaschik BA (2013) Critical evaluation of magnetic resonance imaging targeted, transrectal ultrasound guided transperineal fusion biopsy for detection of prostate cancer. J Urol 190(4):1380–1386. https://doi.org/10.1016/j.juro.2013.04.043 CrossRefPubMed

17.

Kuru TH, Saeb-Parsy K, Cantiani A, Frey J, Lombardo R, Serrao E, Gaziev G, Koo B, Roethke M, Gnanapragasam V, Warren A, Doble A, Hadaschik B, Kastner C (2014) Evolution of repeat prostate biopsy strategies incorporating transperineal and MRI–TRUS fusion techniques. World J Urol 32(4):945–950. https://doi.org/10.1007/s00345-014-1334-1 CrossRefPubMed

18.

Yaxley AJ, Yaxley JW, Thangasamy IA, Ballard E, Pokorny MR (2017) Comparison between target magnetic resonance imaging (MRI) in-gantry and cognitively directed transperineal or transrectal-guided prostate biopsies for prostate imaging-reporting and data system (PI-RADS) 3–5 MRI lesions. BJU Int. https://doi.org/10.1111/bju.13971

19.

Loch T, Eppelmann U, Lehmann J, Wullich B, Loch A, Stöckle M (2004) Transrectal ultrasound guided biopsy of the prostate: random sextant versus biopsies of sono-morphologically suspicious lesions. World J Urol 22(5):357–360. https://doi.org/10.1007/s00345-004-0462-4 CrossRefPubMed

20.

Shoji S, Ukimura O, de Castro Abreu AL, Marien A, Matsugasumi T, Bahn D, Gill IS (2016) Image-based monitoring of targeted biopsy-proven prostate cancer on active surveillance: 11-year experience. World J Urol 34(2):221–227. https://doi.org/10.1007/s00345-015-1619-z CrossRefPubMed

21.

Saad A, Goldstein J, Lawrence YR, Weiss I, Saad R, Spieler B, Symon Z (2015) Transperineal implantation of gold fiducial markers (gold seeds) for prostate image-guided radiation therapy: a feasible technique associated with a low risk of complications. J Med Radiat Sci 62(4):261–266. https://doi.org/10.1002/jmrs.122 CrossRefPubMedPubMedCentral

22.

Grabski B, Baeurle L, Loch A, Wefer B, Paul U, Loch T (2011) Computerized transrectal ultrasound of the prostate in a multicenter setup (C-TRUS-MS): detection of cancer after multiple negative systematic random and in primary biopsies. World J Urol 29(5):573–579. https://doi.org/10.1007/s00345-011-0713-0 CrossRefPubMed

Title: Internal Fusion: exact correlation of transrectal ultrasound images of the prostate by detailed landmarks over time for targeted biopsies or follow-up
Authors: Yanqi Xie
Theodoros Tokas
Björn Grabski
Tillmann Loch
Publication date: 01-05-2018
Publisher: Springer Berlin Heidelberg
Published in: World Journal of Urology / Issue 5/2018
Print ISSN: 0724-4983
Electronic ISSN: 1433-8726
DOI: https://doi.org/10.1007/s00345-017-2161-y

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Internal Fusion: exact correlation of transrectal ultrasound images of the prostate by detailed landmarks over time for targeted biopsies or follow-up

Abstract

Purpose

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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