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01-09-2016 | Original Article

Urinary kidney injury molecule-1 levels in renal stone patients

Authors: Mehmet Balasar, Mehmet Mesut Pişkin, Cemile Topcu, Lütfi Saltuk Demir, Mehmet Gürbilek, Abdulkadir Kandemir, Ahmet Öztürk

Published in: World Journal of Urology | Issue 9/2016

Abstract

Objective

To study kidney injury molecule-1 (KIM-1) biomarker levels, indicating renal tubular damage, in patients with kidney stones and in those who underwent minimally invasive method stone treatment.

Patients and methods

Sixty patients with renal stones between 10 and 20 mm were included into the present study. Patients who were divided into three cohorts underwent micropercutaneous nephrolithotomy (microperc), retrograde intrarenal stone surgery (RIRS), and percutaneous nephrolithotomy (PNL). Urine samples were obtained from all participants before, 4 h and 14 days after the procedure. In all the samples obtained, urinary KIM-1 and creatinine (Cr) levels were measured and KIM-1/Cr ratios (ng/mg creatinine) were calculated.

Results

Preoperative urine KIM-1/Cr ratio was higher than postoperative 14th day. The bigger the renal stone size, the higher was the ratio (correlation coefficient 0.353, p = 0.006). According to preferred treatment procedure, there was a statistically significant decrease in preoperative and postoperative 4th hour and 14th day urine KIM-1/Cr rates in the RIRS and PNL, yet none in the microperc group (p = 0.010, p = 0.001, p = 0.212, respectively).

Conclusion

In renal stone patients, the elevated urine KIM-1/Cr ratio levels increase further according to stone size. KIM-1/Cr ratio is a promising marker might be helpful in monitoring the damage created by stone disease.

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Title: Urinary kidney injury molecule-1 levels in renal stone patients
Authors: Mehmet Balasar
Mehmet Mesut Pişkin
Cemile Topcu
Lütfi Saltuk Demir
Mehmet Gürbilek
Abdulkadir Kandemir
Ahmet Öztürk
Publication date: 01-09-2016
Publisher: Springer Berlin Heidelberg
Published in: World Journal of Urology / Issue 9/2016
Print ISSN: 0724-4983
Electronic ISSN: 1433-8726
DOI: https://doi.org/10.1007/s00345-016-1765-y

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Urinary kidney injury molecule-1 levels in renal stone patients

Abstract

Objective

Patients and methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Objective

Patients and methods

Results

Conclusion

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