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World Journal of Urology

Published in:

01-04-2008 | Topic Paper

Targeted therapy in renal cell carcinoma

Authors: Jean-Jacques Patard, Damien Pouessel, Karim Bensalah, Stéphane Culine

Published in: World Journal of Urology | Issue 2/2008

Abstract

Objective

To present an update on anti-angiogenic drugs in the treatment of metastatic renal cell carcinoma.

Recent findings

A better understanding of molecular pathways that are involved in clear cell carcinomas has led to the development of multiple targeted therapies with significant clinical benefits. Two tyrosine kinase inhibitors targeting the vascular endothelial growth factor (VEGF) receptor have been shown to improve the progression-free survival of patients in first-line (Sunitinib vs. interferon-α) or second-line treatment (Sorafenib vs. placebo). Temsirolimus, an agent that inhibits the serine–threonine kinase activity of the mammalian target of rapamycin, offers better overall survival than interferon in patients with poor-risk characteristics. Finally, Bevacizumab, which is an antibody directed against VEGF, in association with IFN is providing substantial response rates and increased progression-free survival compared to IFN alone.

Conclusion

Four major drugs or regimens with proven efficacy are now available in first and second line therapy in metastatic renal cell carcinoma (mRCC). Further studies are needed to determine the optimal combinations of these agents in metastatic disease and to assess their impact in the adjuvant setting.

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Title: Targeted therapy in renal cell carcinoma
Authors: Jean-Jacques Patard
Damien Pouessel
Karim Bensalah
Stéphane Culine
Publication date: 01-04-2008
Publisher: Springer-Verlag
Published in: World Journal of Urology / Issue 2/2008
Print ISSN: 0724-4983
Electronic ISSN: 1433-8726
DOI: https://doi.org/10.1007/s00345-008-0237-4

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Targeted therapy in renal cell carcinoma

Abstract

Objective

Recent findings

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Objective

Recent findings

Conclusion

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