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01-10-2007 | Topic Paper

Renal transplant rejection markers

Author: Wilfried Gwinner

Published in: World Journal of Urology | Issue 5/2007

Abstract

Acute rejection is one of the key factors which determine long-term graft function and survival in renal transplant patients. Timely detection and treatment of rejection is therefore, an important goal in the post-transplant surveillance. The standard care with serum creatinine measurements and biopsy upon allograft dysfunction implies that acute rejection is detected in an advanced stage. Therefore, non-invasive monitoring for acute rejection by markers in blood and urine has been tried over the past decades. This review describes the requirements that should be met by non-invasive markers. The experience with single biomarkers and with newer approaches—mRNA expression analysis, metabolomics, and proteomics—will be discussed, including future directions of necessary research.

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Title: Renal transplant rejection markers
Author: Wilfried Gwinner
Publication date: 01-10-2007
Publisher: Springer-Verlag
Published in: World Journal of Urology / Issue 5/2007
Print ISSN: 0724-4983
Electronic ISSN: 1433-8726
DOI: https://doi.org/10.1007/s00345-007-0211-6

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Renal transplant rejection markers

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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