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01-02-2006 | Topic Paper

The role of nanobacteria in urologic disease

Authors: Hadley M. Wood, Daniel A. Shoskes

Published in: World Journal of Urology | Issue 1/2006

Abstract

Recent data proposing an extremely small, self-replicating agent termed “nanobacteria” has raised a great deal of controversy within the scientific community. Since these agents have been isolated within the genitourinary tract, much research has focused attention on the potential role these particles may play in the development of urologic pathology, including polycystic kidney disease, renal calculi, and chronic prostatitis. Recent clinical research targeting these agents has proven effective in treating some patients with refractory category III prostatitis (chronic pelvic pain syndrome). This article reviews the current state of nanobacteria research and explore where these particles may impact urologic disease.

Akerman KK, Kuikka JT, Ciftcioglu N et al 1997 Radiolabeling and in vivo distribution of nanobacteria in the rabbit. Proc SPIE Int Soc Opt Eng 3111:436

Benzerara K, Menguy N, Guyot F et al 2003 Nanobacteria-like calcite single crystals at the surface of the Tataouine meteorite. Proc Natl Acad Sci USA 100(13):7438PubMedCrossRef

Bock E, Calugi V, Stolfi C et al 1989 Calcifications of the prostate: a transrectal echographic study. Radiol Med 77:501

Chan D, Jarrett T, Kavoussi L et al 1999 Nanobacteria: role in human renal calculi disease. J Endourol BRS2–11:A7

Ciftcioglu N, Bjorklund M, Kuorikoski K et al 1999 Nanobacteria: an infectious cause for kidney stone formation. Kidney Int 56(5):1893CrossRefPubMed

Ciftcioglu N, Haddad RS, Golden DC et al 2005 A potential cause for kidney stone formation during space flights: enhanced growth of nanobacteria in microgravity. Kidney Int 67(2):483CrossRefPubMed

Cisar JO, Xu DQ, Thompson J et al 2000 An alternative interpretation of nanobacteria-inducted biomineralizationPNAS 97(21):11511CrossRefPubMed

Drancourt M, Jacomo V, Lepidi H et al 2003 Attempted isolation of Nanobacterium sp. Microorganisms from upper urinary tract stones. J Clin Microbiol 41(1):368CrossRefPubMed

Geramoutsos I, Gyftopoulos K, Perimenis P et al 2004 Clinical correlation of prostatic lithiasis with chronic pelvic pain syndromes in young adults. Eur Urol 45:333CrossRefPubMed

10.

Goldfarb DS 2004 Microorganisms and calcium oxalate stone disease. Nephron Physiol 98(2):48CrossRef

11.

Hjelle JT, Miller-Hjelle MA, Poxton IR et al 2000 Endotoxin and nanobacteria in polycystic kidney disease. Kidney Int 57(6):2360CrossRefPubMed

12.

Hudelist G, Singer CF, Kubista E et al 2004 Presence of nanobacteria in psammoma bodies of ovarian cancer: evidence for pathogenetic role in intratumoral biomineralization. Histopathology 45(6):633CrossRefPubMed

13.

Jelic TM, Malas AM, Groves SS et al 2004 Nanobacteria-caused mitral valve calciphylaxis in a man with diabetic renal failure. South med J 97(2):194CrossRefPubMed

14.

Jones JA, Carlson D, Shoskes D et al Association of calcifying nanoparticles within serum and prostates of patients with prostatic inflammation and hyperplasia: a preliminary analysis. Abstract at Society for Infection and Inflammation in Urology 2005 Meeting (San Antonio Tx)

15.

Kajander EO Culture and detection method for sterile-filterable automomously replicating biological particles. US Patent 135,851, 1992

16.

Kajander EO, Ciftcioglu N 1998 Nanobacteria: an alternative mechanism for pathogenic intra- and extracellular calcification and stone formation. PNAS 95:8274CrossRefPubMed

17.

Kajander EO, Kuronene I, Akerman K et al 1997 Nanobacteria from blood, the smallest culturable autonomously replicating agent on Earth. Proc SPIE Int Soc Opt Eng 31111:420

18.

Kajander EO, Ciftcioglu N, Aho K et al 2003 Characteristics of nanobacteria and their possible role in stone formation. Urol Res 31:47PubMed

19.

Khullar M, Sharma SK, Singh SK et al 2004 Morphological and immunological characteristics of nanobacteria from human renal stones of a north Indian population. Urol Res 32:190CrossRefPubMed

20.

Low M, Dallera SA, Troxel HGS et al 1999 Nanobacteria detection in the serum and urine of urinary stone patients versus normal controls. J Endourol BRS2–12:A7

21.

Maniscalco BS, Taylor KA 2004 Calcification in coronary artery disease can be reversed by EDTA-tetracycline long-term chemotherapy. Pathophysiolog 11(2):95CrossRef

22.

Mehik A, Hellstrom P, Nickel JC et al 2002 The chronic prostatitis–chronic pelvic pain syndrome can be characterized by prostatic tissue pressure measurements. J Urol 167:137CrossRefPubMed

23.

Miller VM, Rodgers G, Charlesworth JA et al 2004 Evidence of nanobacterial-like structures in calcified human arteries and cardiac valves. Am J Physiol Heart Circ Physiol 287(3):H1115CrossRefPubMed

24.

Shoskes DA, Thomas KD, Gomez E 2005 Anti-nanobacterial therapy for men with chronic prostatitis/chronic pelvic pain syndrome and prostatic stones: preliminary experience. J Urol 173:474CrossRefPubMed

25.

Sommer AP 2003 Peripheral neuropathy and light-preliminary report indicating prevalence of nanobacteria in HIV. J Proteome Res 2(6):665CrossRefPubMed

26.

Sommer AP, McKay DS, Ciftcioglu N et al 2003 Living Nanovesicles—chemical and physical survival strategies of primordial biosystems. J Proteome Res 2:441CrossRefPubMed

27.

Torres RC, Aguilar RJ, Zuluaga GA et al 1981 Ultrastructure of primary or endogenous prostatic calculi. Scanning electron microscopic study. Arch Esp Urol 34:13PubMed

28.

Wen Y, Yong-guo L, Yang Z et al 2005 Detection of nanobacteria in serum, bile and gallbladder mucosa of patients with cholecystolithiasis. Chin Med J 118(5):421PubMed

Title: The role of nanobacteria in urologic disease
Authors: Hadley M. Wood
Daniel A. Shoskes
Publication date: 01-02-2006
Publisher: Springer-Verlag
Published in: World Journal of Urology / Issue 1/2006
Print ISSN: 0724-4983
Electronic ISSN: 1433-8726
DOI: https://doi.org/10.1007/s00345-005-0041-3

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The role of nanobacteria in urologic disease

Abstract

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Abstract

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