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02-09-2023 | Chest

Diagnostic performance and prognostic value of CT-defined visceral pleural invasion in early-stage lung adenocarcinomas

Authors: Woo Hyeon Lim, Kyung Hee Lee, Jong Hyuk Lee, Hyungin Park, Ju Gang Nam, Eui Jin Hwang, Jin-Haeng Chung, Jin Mo Goo, Samina Park, Young Tae Kim, Hyungjin Kim

Published in: European Radiology | Issue 3/2024

Abstract

Objectives

To analyze the diagnostic performance and prognostic value of CT-defined visceral pleural invasion (CT-VPI) in early-stage lung adenocarcinomas.

Methods

Among patients with clinical stage I lung adenocarcinomas, half of patients were randomly selected for a diagnostic study, in which five thoracic radiologists determined the presence of CT-VPI. Probabilities for CT-VPI were obtained using deep learning (DL). Areas under the receiver operating characteristic curve (AUCs) and binary diagnostic measures were calculated and compared. Inter-rater agreement was assessed. For all patients, the prognostic value of CT-VPI by two radiologists and DL (using high-sensitivity and high-specificity cutoffs) was investigated using Cox regression.

Results

In 681 patients (median age, 65 years [interquartile range, 58–71]; 382 women), pathologic VPI was positive in 130 patients. For the diagnostic study (n = 339), the pooled AUC of five radiologists was similar to that of DL (0.78 vs. 0.79; p = 0.76). The binary diagnostic performance of radiologists was variable (sensitivity, 45.3–71.9%; specificity, 71.6–88.7%). Inter-rater agreement was moderate (weighted Fleiss κ, 0.51; 95%CI: 0.43–0.55). For overall survival (n = 680), CT-VPI by radiologists (adjusted hazard ratio [HR], 1.27 and 0.99; 95%CI: 0.84–1.92 and 0.63–1.56; p = 0.26 and 0.97) or DL (HR, 1.44 and 1.06; 95%CI: 0.86–2.42 and 0.67–1.68; p = 0.17 and 0.80) was not prognostic. CT-VPI by an attending radiologist was prognostic only in radiologically solid tumors (HR, 1.82; 95%CI: 1.07–3.07; p = 0.03).

Conclusion

The diagnostic performance and prognostic value of CT-VPI are limited in clinical stage I lung adenocarcinomas. This feature may be applied for radiologically solid tumors, but substantial reader variability should be overcome.

Clinical relevance statement

Although the diagnostic performance and prognostic value of CT-VPI are limited in clinical stage I lung adenocarcinomas, this parameter may be applied for radiologically solid tumors with appropriate caution regarding inter-reader variability.

Key Points

• Use of CT-defined visceral pleural invasion in clinical staging should be cautious, because prognostic value of CT-defined visceral pleural invasion remains unexplored.

• Diagnostic performance and prognostic value of CT-defined visceral pleural invasion varied among radiologists and deep learning.

• Role of CT-defined visceral pleural invasion in clinical staging may be limited to radiologically solid tumors.

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Title: Diagnostic performance and prognostic value of CT-defined visceral pleural invasion in early-stage lung adenocarcinomas
Authors: Woo Hyeon Lim
Kyung Hee Lee
Jong Hyuk Lee
Hyungin Park
Ju Gang Nam
Eui Jin Hwang
Jin-Haeng Chung
Jin Mo Goo
Samina Park
Young Tae Kim
Hyungjin Kim
Publication date: 02-09-2023
Publisher: Springer Berlin Heidelberg
Published in: European Radiology / Issue 3/2024
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-023-10204-2

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Diagnostic performance and prognostic value of CT-defined visceral pleural invasion in early-stage lung adenocarcinomas

Abstract

Objectives

Methods

Results

Conclusion

Clinical relevance statement

Key Points

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Objectives

Methods

Results

Conclusion

Clinical relevance statement

Key Points

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