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01-02-2020 | Cardiac

Myocardial extracellular volume quantification in cardiac CT: comparison of the effects of two different iterative reconstruction algorithms with MRI as a reference standard

Authors: Takafumi Emoto, Masafumi Kidoh, Seitaro Oda, Takeshi Nakaura, Yasunori Nagayama, Akira Sasao, Yoshinori Funama, Satoshi Araki, Seiji Takashio, Kenji Sakamoto, Eiichiro Yamamoto, Koichi Kaikita, Kenichi Tsujita, Yasuyuki Yamashita

Published in: European Radiology | Issue 2/2020

Abstract

Objectives

To compare the effects of hybrid iterative reconstruction (HIR) and model-based iterative reconstruction (MBIR) that incorporates a beam-hardening model for myocardial extracellular volume (ECV) quantification by cardiac CT using MRI as a reference standard.

Methods

In this retrospective study, a total of 34 patients were evaluated using cardiac CT and MRI. Paired CT image sets were created using HIR and MBIR with a beam-hardening model. We calculated mean absolute differences and correlations between the global mid-ventricular ECV derived from CT and MRI via Pearson correlation analysis. In addition, we performed qualitative analysis of image noise and beam-hardening artifacts on postcontrast images using a four-point scale: 1 = extensive, 2 = strong, 3 = mild, and 4 = minimal.

Results

The mean absolute difference between the ECV derived from CT and MRI for MBIR was significantly smaller than that for HIR (MBIR 3.74 ± 3.59%; HIR 4.95 ± 3.48%, p = 0.034). MBIR improved the correlation between the ECV derived from CT and MRI when compared with HIR (MBIR, r = 0.60, p < 0.001; HIR, r = 0.47, p = 0.006). In qualitative analysis, MBIR significantly reduced image noise and beam-hardening artifacts when compared with HIR ([image noise, MBIR 3.4 ± 0.7; HIR 2.1 ± 0.8, p < 0.001], [beam-hardening artifacts, MBIR 3.8 ± 0.4; HIR 2.6 ± 1.0, p < 0.001]).

Conclusions

MBIR with a beam-hardening model effectively reduced image noise and beam-hardening artifacts and improved myocardial ECV quantification when compared with HIR using MRI as a reference standard.

Key Points

• MBIR with a beam-hardening model effectively reduced image noise and beam-hardening artifacts.

• The mean absolute difference between the global mid-ventricular ECV derived from CT and MRI for MBIR was significantly smaller than that for conventional HIR.

• MBIR provided more accurate myocardial CT number and improved ECV quantification when compared with HIR.

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Title: Myocardial extracellular volume quantification in cardiac CT: comparison of the effects of two different iterative reconstruction algorithms with MRI as a reference standard
Authors: Takafumi Emoto
Masafumi Kidoh
Seitaro Oda
Takeshi Nakaura
Yasunori Nagayama
Akira Sasao
Yoshinori Funama
Satoshi Araki
Seiji Takashio
Kenji Sakamoto
Eiichiro Yamamoto
Koichi Kaikita
Kenichi Tsujita
Yasuyuki Yamashita
Publication date: 01-02-2020
Publisher: Springer Berlin Heidelberg
Published in: European Radiology / Issue 2/2020
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-019-06418-y

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Myocardial extracellular volume quantification in cardiac CT: comparison of the effects of two different iterative reconstruction algorithms with MRI as a reference standard

Abstract

Objectives

Methods

Results

Conclusions

Key Points

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Objectives

Methods

Results

Conclusions

Key Points

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