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European Radiology
Published in: European Radiology 12/2019

Open Access 01-12-2019 | Magnetic Resonance Imaging | Neuro

SyMRI detects delayed myelination in preterm neonates

Authors: Victor Schmidbauer, Gudrun Geisl, Mariana Diogo, Michael Weber, Katharina Goeral, Katrin Klebermass-Schrehof, Angelika Berger, Daniela Prayer, Gregor Kasprian

Published in: European Radiology | Issue 12/2019

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Abstract

Objectives

The software “SyMRI” generates different MR contrasts and characterizes tissue properties based on a single acquisition of a multi-dynamic multi-echo (MDME)-FLAIR sequence. The aim of this study was to assess the applicability of “SyMRI” in the assessment of myelination in preterm and term-born neonates. Furthermore, “SyMRI” was compared with conventional MRI.

Methods

A total of 30 preterm and term-born neonates were examined at term-equivalent age using a standardized MRI protocol. MDME sequence (acquisition time, 5 min, 24 s)–based post-processing was performed using “SyMRI”. Myelination was assessed by scoring seven brain regions on quantitative T1-/T2-maps, generated by “SyMRI” and on standard T1-/T2-weighted images, acquired separately. Analysis of covariance (ANCOVA) (covariate, gestational age (GA) at MRI (GAMRI)) was used for group comparison.

Results

In 25/30 patients (83.3%) (18 preterm and seven term-born neonates), “SyMRI” acquisitions were successfully performed. “SyMRI”-based myelination scores were significantly lower in preterm compared with term-born neonates (ANCOVA: T1: F(1, 22) = 7.420, p = 0.012; T2: F(1, 22) = 5.658, p = 0.026). “SyMRI”-based myelination scores positively correlated with GAMRI (T1: r = 0.662, n = 25, p ≤ 0.001; T2: r = 0.676, n = 25, p ≤ 0.001). The myelination scores based on standard MRI did not correlate with the GAMRI. No significant differences between preterm and term-born neonates were detectable.

Conclusions

“SyMRI” is a highly promising MR technique for neonatal brain imaging. “SyMRI” is superior to conventional MR sequences in the visual detection of delayed myelination in preterm neonates.

Key Points

• By providing multiple MR contrasts, “SyMRI” is a time-saving method in neonatal brain imaging.
• Differences concerning the myelination in term-born and preterm infants are visually detectable on T1-/T2-weighted maps generated by “SyMRI”.
• “SyMRI” allows a faster and more sensitive assessment of myelination compared with standard MR sequences.
Appendix
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Metadata
Title
SyMRI detects delayed myelination in preterm neonates
Authors
Victor Schmidbauer
Gudrun Geisl
Mariana Diogo
Michael Weber
Katharina Goeral
Katrin Klebermass-Schrehof
Angelika Berger
Daniela Prayer
Gregor Kasprian
Publication date
01-12-2019
Publisher
Springer Berlin Heidelberg
Published in
European Radiology / Issue 12/2019
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI
https://doi.org/10.1007/s00330-019-06325-2

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