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European Radiology

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01-04-2018 | Magnetic Resonance

Application of DWIBS in malignant lymphoma: correlation between ADC values and Ki-67 index

Authors: Mengtian Sun, Jingliang Cheng, Yong Zhang, Jie Bai, Feifei Wang, Yun Meng, Zhenqian Li

Published in: European Radiology | Issue 4/2018

Abstract

Objectives

We investigated the correlation between the apparent diffusion coefficient (ADC) and Ki-67 index using diffusion-weighted whole-body imaging with background body signal suppression (DWIBS), and their utility in evaluating malignant lymphoma cell proliferation.

Materials and Methods

Seventy-four patients with malignant lymphoma underwent DWIBS within 1 week before pathological confirmation. The ADC value was measured at the site of the pathological examination, and specimens were also stained with Ki-67. The ADC values and Ki-67 indices in aggressive non-Hodgkin's lymphoma (NHL), indolent NHL, and Hodgkin's lymphoma (HL) were compared using Spearman's rank correlation coefficient and the Kruskal-Wallis test.

Results

The Ki-67 indices and ADC values were inversely correlated (r = -0.289, p = 0.0125); the differences in the Ki-67 index between aggressive NHL, indolent NHL, and HL were significant (p < 0.001); this was confirmed by the Nemenyi test except for indolent NHL vs. HL. The ADC values were significantly different between the types of lymphoma (p = 0.013); the Nemenyi test showed a significant difference only between aggressive NHL and HL.

Conclusions

The Ki-67 indices and ADC values are inversely correlated in patients with lymphoma, combining DWIBS and ADC values can evaluate the proliferation level of malignant lymphoma cells noninvasively.

Key points

• By using DWIBS, malignant lymphoma cell proliferation can be assessed noninvasively.

• The ADC value and Ki-67 index are significantly and inversely correlated.

• The ADC values were lower in aggressive NHL than in HL.

• The ADC values of aggressive and indolent NHL were not significantly different.

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Title: Application of DWIBS in malignant lymphoma: correlation between ADC values and Ki-67 index
Authors: Mengtian Sun
Jingliang Cheng
Yong Zhang
Jie Bai
Feifei Wang
Yun Meng
Zhenqian Li
Publication date: 01-04-2018
Publisher: Springer Berlin Heidelberg
Published in: European Radiology / Issue 4/2018
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-017-5135-y

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Application of DWIBS in malignant lymphoma: correlation between ADC values and Ki-67 index

Abstract

Objectives

Materials and Methods

Results

Conclusions

Key points

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Objectives

Materials and Methods

Results

Conclusions

Key points

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