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01-10-2017 | Contrast Media

Signal intensity change on unenhanced T1-weighted images in dentate nucleus and globus pallidus after multiple administrations of gadoxetate disodium: an intraindividual comparative study

Authors: Giorgio Conte, Lorenzo Preda, Emilia Cocorocchio, Sara Raimondi, Caterina Giannitto, Marta Minotti, Francesca De Piano, Giuseppe Petralia, Pier Francesco Ferrucci, Massimo Bellomi

Published in: European Radiology | Issue 10/2017

Abstract

Purpose

To investigate whether there is an increased signal intensity (SI) of dentate nucleus (DN) and globus pallidus (GP) on unenhanced T1-weighted magnetic resonance imaging (MRI), in patients who had undergone multiple administrations of gadoxetate disodium.

Materials and methods

We retrospectevely included stage III melanoma patients, who had been previously enrolled in a trial of adjuvant therapy and who had undergone whole-body contrast-enhanced MRIs with gadoxetate disodium every three months for their follow-up. The SI ratios of DN-to-pons and GP-to-thalamus on unenhanced T1-weighted images were calculated. The difference in SI ratios between the first and the last MRI examinations was assessed and a linear mixed model was performed to detect how SI ratios varied with the number of administrations.

Results

Eighteen patients were included in our study. The number of gadoxetate disodium administrations ranged from 2 to 18. Paired t-test did not show any significant difference in DN-to-pons (p=0.21) and GP-to-thalamus (p=0.09) SI ratios by the end of the study. DN-to-pons SI ratio and GP-to-thalamus SI ratio did not significantly increase with increasing the number of administrations (p=0.14 and p=0.06, respectively).

Conclusion

Multiple administrations of gadoxetate disodium are not associated with increased SI in DN and GP in the brain.

Key Points

• Gadolinium may deposit in the human brain after multiple GBCA administrations.

• Gadolinium deposition is associated with increased T1W signal intensity

• Increase in signal intensity is most apparent within the DN and GP

• Multiple administrations of gadoxetate disodium do not increase T1W signal

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Title: Signal intensity change on unenhanced T1-weighted images in dentate nucleus and globus pallidus after multiple administrations of gadoxetate disodium: an intraindividual comparative study
Authors: Giorgio Conte
Lorenzo Preda
Emilia Cocorocchio
Sara Raimondi
Caterina Giannitto
Marta Minotti
Francesca De Piano
Giuseppe Petralia
Pier Francesco Ferrucci
Massimo Bellomi
Publication date: 01-10-2017
Publisher: Springer Berlin Heidelberg
Published in: European Radiology / Issue 10/2017
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-017-4810-3

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Signal intensity change on unenhanced T1-weighted images in dentate nucleus and globus pallidus after multiple administrations of gadoxetate disodium: an intraindividual comparative study

Abstract

Purpose

Materials and methods

Results

Conclusion

Key Points

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Materials and methods

Results

Conclusion

Key Points

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