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European Radiology
Published in: European Radiology 5/2017

01-05-2017 | Neuro

Multifrequency magnetic resonance elastography of the brain reveals tissue degeneration in neuromyelitis optica spectrum disorder

Authors: Kaspar-Josche Streitberger, Andreas Fehlner, Florence Pache, Anna Lacheta, Sebastian Papazoglou, Judith Bellmann-Strobl, Klemens Ruprecht, Alexander Brandt, Jürgen Braun, Ingolf Sack, Friedemann Paul, Jens Wuerfel

Published in: European Radiology | Issue 5/2017

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Abstract

Objectives

Application of multifrequency magnetic resonance elastography (MMRE) of the brain parenchyma in patients with neuromyelitis optica spectrum disorder (NMOSD) compared to age matched healthy controls (HC).

Methods

15 NMOSD patients and 17 age- and gender-matched HC were examined using MMRE. Two three-dimensional viscoelastic parameter maps, the magnitude |G*| and phase angle φ of the complex shear modulus were reconstructed by simultaneous inversion of full wave-field data in 1.9-mm isotropic resolution at 7 harmonic drive frequencies from 30 to 60 Hz.

Results

In NMOSD patients, a significant reduction of |G*| was observed within the white matter fraction (p = 0.017), predominantly within the thalamic regions (p = 0.003), compared to HC. These parameters exceeded the reduction in brain volume measured in patients versus HC (p = 0.02 whole-brain volume reduction). Volumetric differences in white matter fraction and the thalami were not detectable between patients and HC. However, phase angle φ was decreased in patients within the white matter (p = 0.03) and both thalamic regions (p = 0.044).

Conclusions

MMRE reveals global tissue degeneration with accelerated softening of the brain parenchyma in patients with NMOSD. The predominant reduction of stiffness is found within the thalamic region and related white matter tracts, presumably reflecting Wallerian degeneration.

Key Points

• Magnetic resonance elastography reveals diffuse cerebral tissue changes in patients with NMOSD.
• Premature tissue softening in NMOSD patients indicates tissue degeneration.
• Hypothesis of a widespread cerebral neurodegeneration in form of diffuse tissue alteration.
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Metadata
Title
Multifrequency magnetic resonance elastography of the brain reveals tissue degeneration in neuromyelitis optica spectrum disorder
Authors
Kaspar-Josche Streitberger
Andreas Fehlner
Florence Pache
Anna Lacheta
Sebastian Papazoglou
Judith Bellmann-Strobl
Klemens Ruprecht
Alexander Brandt
Jürgen Braun
Ingolf Sack
Friedemann Paul
Jens Wuerfel
Publication date
01-05-2017
Publisher
Springer Berlin Heidelberg
Published in
European Radiology / Issue 5/2017
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI
https://doi.org/10.1007/s00330-016-4561-6

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