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Open Access 01-01-2017 | Cardiac

Native myocardial T1 mapping in pulmonary hypertension: correlations with cardiac function and hemodynamics

Authors: Ursula Reiter, Gert Reiter, Gabor Kovacs, Gabriel Adelsmayr, Andreas Greiser, Horst Olschewski, Michael Fuchsjäger

Published in: European Radiology | Issue 1/2017

Abstract

Objectives

To analyze alterations in left ventricular (LV) myocardial T1 times in patients with pulmonary hypertension (PH) and to investigate their associations with ventricular function, mass, geometry and hemodynamics.

Methods

Fifty-eight patients with suspected PH underwent right heart catheterization (RHC) and 3T cardiac magnetic resonance imaging. Ventricular function, geometry and mass were derived from cine real-time short-axis images. Myocardial T1 maps were acquired by a prototype modified Look-Locker inversion-recovery sequence in short-axis orientations. LV global, segmental and ventricular insertion point (VIP) T1 times were evaluated manually and corrected for blood T1.

Results

Septal, lateral, global and VIP T1 times were significantly higher in PH than in non-PH subjects (septal, 1249 ± 58 ms vs. 1186 ± 33 ms, p < 0.0001; lateral, 1190 ± 45 ms vs. 1150 ± 33 ms, p = 0.0003; global, 1220 ± 52 ms vs. 1171 ± 29 ms, p < 0.0001; VIP, 1298 ± 78 ms vs. 1193 ± 31 ms, p < 0.0001). In PH, LV eccentricity index was the strongest linear predictor of VIP T1 (r = 0.72). Septal, lateral and global T1 showed strong correlations with VIP T1 (r = 0.81, r = 0.59 and r = 0.75, respectively).

Conclusions

In patients with PH, T1 times in VIPs and in the entire LV myocardium are elevated. LV eccentricity strongly correlates with VIP T1 time, which in turn is strongly associated with T1 time changes in the entire LV myocardium.

Key Points

• Native T1 mapping detects left ventricular myocardial alterations in pulmonary hypertension

• In pulmonary hypertension, native T1 times at ventricular insertion points are increased

• These T1 times correlate strongly with left ventricular eccentricity

• In pulmonary hypertension, global and segmental myocardial T1 times are increased

• Global, segmental and ventricular insertion point T1 times are strongly correlated

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Title: Native myocardial T1 mapping in pulmonary hypertension: correlations with cardiac function and hemodynamics
Authors: Ursula Reiter
Gert Reiter
Gabor Kovacs
Gabriel Adelsmayr
Andreas Greiser
Horst Olschewski
Michael Fuchsjäger
Publication date: 01-01-2017
Publisher: Springer Berlin Heidelberg
Published in: European Radiology / Issue 1/2017
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-016-4360-0

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Native myocardial T1 mapping in pulmonary hypertension: correlations with cardiac function and hemodynamics

Abstract

Objectives

Methods

Results

Conclusions

Key Points

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Objectives

Methods

Results

Conclusions

Key Points

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