Published in:
Open Access 01-01-2016 | Breast
Performance of one-view breast tomosynthesis as a stand-alone breast cancer screening modality: results from the Malmö Breast Tomosynthesis Screening Trial, a population-based study
Published in: European Radiology | Issue 1/2016
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Objective
To assess the performance of one-view digital breast tomosynthesis (DBT) in breast cancer screening.
Methods
The Malmö Breast Tomosynthesis Screening Trial is a prospective population-based one-arm study with a planned inclusion of 15000 participants; a random sample of women aged 40–74 years eligible for the screening programme. This is an explorative analysis of the first half of the study population (n = 7500). Participants underwent one-view DBT and two-view digital mammography (DM), with independent double reading and scoring. Primary outcome measures were detection rate, recall rate and positive predictive value (PPV). McNemar's test with 95 % confidence intervals was used.
Results
Breast cancer was found in sixty-eight women. Of these, 46 cases were detected by both modalities, 21 by DBT alone and one by DM alone. The detection rate for one-view DBT was 8.9/1000 screens (95 % CI 6.9 to 11.3) and 6.3/1000 screens (4.6 to 8.3) for two-view DM (p < 0.0001). The recall rate after arbitration was 3.8 % (3.3 to 4.2) for DBT and 2.6 % (2.3 to 3.0) for DM (p < 0.0001). The PPV was 24 % for both DBT and DM.
Conclusion
Our results suggest that one-view DBT might be feasible as a stand-alone screening modality.
Key Points
• One-view DBT as a stand-alone breast cancer screening modality has not been investigated.
• One-view DBT increased the cancer detection rate significantly.
• The recall rate increased significantly but was still low.
• Breast cancer screening with one-view DBT as a stand-alone modality seems feasible.